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MUR1 NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 824280, updated on 18-Sep-2024

Summary

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Official Symbol
MUR1
Official Full Name
NAD(P)-binding Rossmann-fold superfamily protein
Primary source
TAIR:AT3G51160
Locus tag
AT3G51160
See related
Araport:AT3G51160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
6-DEHYDRATASE; 6-DEHYDRATASE 2; GDP-D-MANNOSE-4; GMD2; MURUS 1; MUR_1
Summary
Catalyzes the first step in the de novo synthesis of GDP-L-fucose.
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Genomic context

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See MUR1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
1
Sequence:
Chromosome: 3; NC_003074.8 (19006993..19008724, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene DnaJ (DUF3353) Neighboring gene tRNA-Glu Neighboring gene ATP binding microtubule motor family protein Neighboring gene miscRNA Neighboring gene F-box and associated interaction domains-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. MUR1-mediated cell-wall fucosylation is required for freezing tolerance in Arabidopsis thaliana. Panter PE, et al. New Phytol, 2019 Dec. PMID 31549420, Free PMC Article
  2. Fucosylated arabinogalactan-proteins are required for full root cell elongation in arabidopsis. van Hengel AJ, et al. Plant J, 2002 Oct. PMID 12366804
  3. The MUR1 gene of Arabidopsis thaliana encodes an isoform of GDP-D-mannose-4,6-dehydratase, catalyzing the first step in the de novo synthesis of GDP-L-fucose. Bonin CP, et al. Proc Natl Acad Sci U S A, 1997 Mar 4. PMID 9050909, Free PMC Article
  4. Interaction of GDP-4-keto-6-deoxymannose-3,5-epimerase-4-reductase with GDP-mannose-4,6-dehydratase stabilizes the enzyme activity for formation of GDP-fucose from GDP-mannose. Nakayama K, et al. Glycobiology, 2003 Oct. PMID 12881408
  5. The Arabidopsis metacaspase9 degradome. Tsiatsiani L, et al. Plant Cell, 2013 Aug. PMID 23964026, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MUR1 role in the freezing tolerance in Arabidopsis.
    Title: MUR1-mediated cell-wall fucosylation is required for freezing tolerance in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_114976.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GDP-mannose 4,6-dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GDP-mannose 4,6-dehydratase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within 'de novo' GDP-L-fucose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in GDP-mannose metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within unidimensional cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NAD(P)-binding Rossmann-fold superfamily protein
NP_190685.2
  • MURUS 1 (MUR1); FUNCTIONS IN: GDP-mannose 4,6-dehydratase activity; INVOLVED IN: 'de novo' GDP-L-fucose biosynthetic process, unidimensional cell growth; LOCATED IN: cytosol; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: NAD-dependent epimerase/dehydratase (InterPro:IPR001509), NAD(P)-binding domain (InterPro:IPR016040), GDP-mannose 4,6-dehydratase (InterPro:IPR006368); BEST Arabidopsis thaliana protein match is: GDP-D-mannose 4,6-dehydratase 1 (TAIR:AT5G66280.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    19006993..19008724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114976.4 → NP_190685.2  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190685.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93031, Q1ECM4, Q8LFY4, Q9SD30
    UniProtKB/TrEMBL
    A0A178V6B0, A0A5S9XKJ8, A0A654GF27
    Conserved Domains (1) summary
    PLN02653
    Location:23 → 363
    PLN02653; GDP-mannose 4,6-dehydratase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P93031.3

Gene LinkOut

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