TRX1 thioredoxin H-type 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TRX1
Official Full Name: thioredoxin H-type 1
Primary source: TAIR:AT3G51030
Locus tag: AT3G51030
See related: Araport:AT3G51030
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS THALIANA THIOREDOXIN H-TYPE 1; ATTRX H1; ATTRX1; THIOREDOXIN; thioredoxin H-type 1
Summary: encodes a cytosolic thioredoxin that reduces disulfide bridges of target proteins by the reversible formation of a disulfide bridge between two neighboring Cys residues present in the active site. Thioredoxins have been found to regulate a variety of biological reactions in prokaryotic and eukaryotic cells.
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Genomic context

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See TRX1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 3

Sequence:: Chromosome: 3; NC_003074.8 (18950918..18952109, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Crystallization and X-ray crystallographic analysis of recombinant Trx1 has been reported.
Title: Recombinant ACHT1 from Arabidopsis thaliana: crystallization and X-ray crystallographic analysis.
Data indicate that thioredoxin h proteins are not required to prevent the spontaneous activation of S-locus receptor kinase (SRK) in the stigma.
Title: In planta assessment of the role of thioredoxin h proteins in the regulation of S-locus receptor kinase signaling in transgenic Arabidopsis.
Redox regulation of AtCPK21 by Trx-h1 in Arabidopsis thaliana in response to external stimuli is important for appropriate cellular responses.
Title: Thioredoxin h regulates calcium dependent protein kinases in plasma membranes.
Structral model of thioredoxin h1 from Arabidopsis thaliana in the oxidized state displays the conserved thioredoxin fold.
Title: Solution structure of thioredoxin h1 from Arabidopsis thaliana.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_114963.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables enzyme activator activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-disulfide reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in positive regulation of catalytic activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytosol	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: thioredoxin H-type 1

NP_190672.1

thioredoxin H-type 1 (TRX1); FUNCTIONS IN: oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor; INVOLVED IN: cell redox homeostasis; LOCATED IN: cytosol; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin domain (InterPro:IPR013766), Thioredoxin, conserved site (InterPro:IPR017937), Thioredoxin-like subdomain (InterPro:IPR006662), Thioredoxin-like (InterPro:IPR017936), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: thioredoxin H-type 5 (TAIR:AT1G45145.1); Has 18017 Blast hits to 17697 proteins in 2965 species: Archae - 232; Bacteria - 9905; Metazoa - 1876; Fungi - 909; Plants - 1960; Viruses - 5; Other Eukaryotes - 3130 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

18950918..18952109 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114963.5 → NP_190672.1 thioredoxin H-type 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190672.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P29448

UniProtKB/TrEMBL

A0A178VFN9, A0A5S9XJQ0, A0A654FER1

Conserved Domains (1) summary

cd02947
Location:19 → 110

TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...