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EDS1 alpha/beta-Hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823964, updated on 18-Sep-2024

Summary

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Official Symbol
EDS1
Official Full Name
alpha/beta-Hydrolases superfamily protein
Primary source
TAIR:AT3G48090
Locus tag
AT3G48090
See related
Araport:AT3G48090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATEDS1; EDS1 PROTEIN; enhanced disease susceptibility 1
Summary
Component of R gene-mediated disease resistance in Arabidopsis thaliana with homology to eukaryotic lipases.
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Genomic context

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See EDS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Sequence:
Chromosome: 3; NC_003074.8 (17755329..17758147, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene BAH and TFIIS domain-containing protein Neighboring gene RING/U-box superfamily protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene response regulator 5 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1. Johanndrees O, et al. Plant Physiol, 2023 Jan 2. PMID 36227084, Free PMC Article
  2. Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation. Voss M, et al. J Struct Biol, 2019 Dec 1. PMID 31550533
  3. Arabidopsis ENHANCED DISEASE SUSCEPTIBILITY1 promotes systemic acquired resistance via azelaic acid and its precursor 9-oxo nonanoic acid. Wittek F, et al. J Exp Bot, 2014 Nov. PMID 25114016, Free PMC Article
  4. EDS1 contributes to nonhost resistance of Arabidopsis thaliana against Erwinia amylovora. Moreau M, et al. Mol Plant Microbe Interact, 2012 Mar. PMID 22316300
  5. Salicylic acid antagonism of EDS1-driven cell death is important for immune and oxidative stress responses in Arabidopsis. Straus MR, et al. Plant J, 2010 May 1. PMID 20163553

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
    Title: Cold priming on pathogen susceptibility in the Arabidopsis eds1 mutant background requires a functional stromal Ascorbate Peroxidase.
  2. Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
    Title: Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1.
  3. The BZR1-EDS1 module regulates plant growth-defense coordination.
    Title: The BZR1-EDS1 module regulates plant growth-defense coordination.
  4. The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
    Title: The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity.
  5. The immune components ENHANCED DISEASE SUSCEPTIBILITY 1 and PHYTOALEXIN DEFICIENT 4 are required for cell death caused by overaccumulation of ceramides in Arabidopsis.
    Title: The immune components ENHANCED DISEASE SUSCEPTIBILITY 1 and PHYTOALEXIN DEFICIENT 4 are required for cell death caused by overaccumulation of ceramides in Arabidopsis.
  6. Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
    Title: Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity.
  7. EDS1 is a monomeric protein when not part of a heterodimer with its signaling partners, PAD4 or SAG101.
    Title: Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation.
  8. AtEDS1-AtSAG101 functions together with N REQUIRED GENE1 (AtNRG1) coiled-coil domain helper NLRs as a coevolved TNL cell death-signaling module.
    Title: A Coevolved EDS1-SAG101-NRG1 Module Mediates Cell Death Signaling by TIR-Domain Immune Receptors.
  9. DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis
    Title: DELLA and EDS1 Form a Feedback Regulatory Module to Fine-Tune Plant Growth-Defense Tradeoff in Arabidopsis.
  10. PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity
    Title: PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001035752.1
NM_114678.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within aerenchyma formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf abscission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within plant-type hypersensitive response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant-type hypersensitive response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of hydrogen peroxide metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to singlet oxygen IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within systemic acquired resistance IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within systemic acquired resistance, salicylic acid mediated signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
alpha/beta-Hydrolases superfamily protein
NP_001030829.1
  • enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_190392.1
  • enhanced disease susceptibility 1 (EDS1); CONTAINS InterPro DOMAIN/s: Lipase, class 3 (InterPro:IPR002921); BEST Arabidopsis thaliana protein match is: alpha/beta-Hydrolases superfamily protein (TAIR:AT3G48080.1); Has 536 Blast hits to 485 proteins in 45 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 2; Plants - 491; Viruses - 0; Other Eukaryotes - 37 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    17755329..17758147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114678.4 → NP_190392.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190392.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DFM5, Q9SU72
    UniProtKB/TrEMBL
    B2BDD6
    Conserved Domains (1) summary
    pfam01764
    Location:81 → 197
    Lipase_3; Lipase (class 3)

  2. NM_001035752.1 → NP_001030829.1  alpha/beta-Hydrolases superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030829.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2BDD6
    Conserved Domains (1) summary
    cl21494
    Location:8 → 89
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SU72.1

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