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CARA carbamoyl phosphate synthetase A [ Arabidopsis thaliana (thale cress) ]

Gene ID: 822396, updated on 7-Sep-2023

Summary

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Gene symbol
CARA
Gene description
carbamoyl phosphate synthetase A
Primary source
Araport:AT3G27740
Locus tag
AT3G27740
See related
TAIR:AT3G27740
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
carbamoyl phosphate synthetase A; CARBAMOYL PHOSPHATE SYNTHETASE SMALL SUBUNIT; VEN6; VENOSA 6
Summary
Encodes carbamoyl phosphate synthetase (CPS) small subunit (carA), also named as VEN6. Heterologous expression of the Arabidopsis VEN3 and VEN6 genes in a CPS-deficient Escherichia coli strain fully restored bacterial growth in minimal medium, demonstrating the enzymatic activity of the VEN3 and VEN6 proteins.
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Genomic context

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See CARA in Genome Data Viewer
Location:
chromosome: 3
Exon count:
10
Sequence:
Chromosome: 3; NC_003074.8 (10281230..10283935, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene IBR domain containing protein Neighboring gene DNA helicase ROCK-N-ROLLERS Neighboring gene ncRNA Neighboring gene PPR containing protein Neighboring gene plant/protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Analysis of ven3 and ven6 reticulate mutants reveals the importance of arginine biosynthesis in Arabidopsis leaf development. Mollá-Morales A, et al. Plant J, 2011 Feb. PMID 21265888
  2. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
  3. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
  4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
  5. Analysis of the Arabidopsis cytosolic proteome highlights subcellular partitioning of central plant metabolism. Ito J, et al. J Proteome Res, 2011 Apr 1. PMID 21166475

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001084749.1
NM_113690.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in arginine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of carbamoyl-phosphate synthase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
carbamoyl phosphate synthetase A
NP_001078218.1
  • carbamoyl phosphate synthetase A (CARA); FUNCTIONS IN: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, catalytic activity; INVOLVED IN: cellular response to phosphate starvation; LOCATED IN: chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Glutamine amidotransferase superfamily (InterPro:IPR011702), Carbamoyl phosphate synthase, GATase domain (InterPro:IPR001317), Carbamoyl phosphate synthase, small subunit, N-terminal (InterPro:IPR002474), Glutamine amidotransferase type 1 (InterPro:IPR017926), Carbamoyl phosphate synthase, small subunit (InterPro:IPR006274), Anthranilate synthase component II/delta crystallin (InterPro:IPR006220); BEST Arabidopsis thaliana protein match is: anthranilate synthase beta subunit 1 (TAIR:AT1G25220.1); Has 28262 Blast hits to 23423 proteins in 4115 species: Archae - 591; Bacteria - 17320; Metazoa - 1741; Fungi - 716; Plants - 245; Viruses - 0; Other Eukaryotes - 7649 (source: NCBI BLink).
NP_566824.1
  • carbamoyl phosphate synthetase A (CARA); FUNCTIONS IN: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity, catalytic activity; INVOLVED IN: cellular response to phosphate starvation; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Glutamine amidotransferase class-I, C-terminal (InterPro:IPR000991), Glutamine amidotransferase superfamily (InterPro:IPR011702), Carbamoyl phosphate synthase, GATase domain (InterPro:IPR001317), Carbamoyl phosphate synthase, small subunit, N-terminal (InterPro:IPR002474), Glutamine amidotransferase type 1 (InterPro:IPR017926), Carbamoyl phosphate synthase, small subunit (InterPro:IPR006274), Anthranilate synthase component II/delta crystallin (InterPro:IPR006220); BEST Arabidopsis thaliana protein match is: anthranilate synthase beta subunit 1 (TAIR:AT1G25220.1); Has 23531 Blast hits to 23511 proteins in 4128 species: Archae - 520; Bacteria - 13864; Metazoa - 1675; Fungi - 510; Plants - 198; Viruses - 0; Other Eukaryotes - 6764 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    10281230..10283935 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113690.3 → NP_566824.1  carbamoyl phosphate synthetase A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566824.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O24447, Q9LVW7
    UniProtKB/TrEMBL
    A0A178VAM7, A0A7G2ENW7
    Conserved Domains (1) summary
    PLN02771
    Location:1 → 416
    PLN02771; carbamoyl-phosphate synthase (glutamine-hydrolyzing)

  2. NM_001084749.1 → NP_001078218.1  carbamoyl phosphate synthetase A [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078218.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2ENW7, A8MRD8
    Conserved Domains (3) summary
    cd01744
    Location:172 → 348
    GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
    PLN02771
    Location:1 → 344
    PLN02771; carbamoyl-phosphate synthase (glutamine-hydrolyzing)
    pfam00988
    Location:58 → 122
    CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LVW7.1

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