AGC2-1 AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: AGC2-1
Official Full Name: AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein
Primary source: TAIR:AT3G25250
Locus tag: AT3G25250
See related: Araport:AT3G25250
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AGC2; AGC2 kinase 1; AtOXI1; OXI1; oxidative signal-inducible1
Summary: Arabidopsis protein kinase
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Genomic context

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See AGC2-1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (9195334..9197126)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6.
Title: AGC kinases OXI1 and AGC2-2 regulate camalexin secretion and disease resistance by phosphorylating transporter PDR6.
OXIDATIVE SIGNAL-INDUCIBLE1 induces immunity by coordinating N-hydroxypipecolic acid, salicylic acid, and camalexin synthesis.
Title: OXIDATIVE SIGNAL-INDUCIBLE1 induces immunity by coordinating N-hydroxypipecolic acid, salicylic acid, and camalexin synthesis.
OXI1 and DAD Regulate Light-Induced Cell Death Antagonistically through Jasmonate and Salicylate Levels.
Title: OXI1 and DAD Regulate Light-Induced Cell Death Antagonistically through Jasmonate and Salicylate Levels.
The results suggest that resistance in oxi1-2 mutants is through induction of callose deposition via MAPKs resulting in ROS induction as an early response.
Title: OXI1 kinase plays a key role in resistance of Arabidopsis towards aphids (Myzus persicae).
Results show that OXI1 is a regulator of singlet oxygen ((1)O2)-induced programmed cell death (PCD).
Title: Singlet Oxygen-Induced Cell Death in Arabidopsis under High-Light Stress Is Controlled by OXI1 Kinase.
This study has identified a range of candidate proteins from the OXI1 signalling pathway.
Title: The phosphoproteome of Arabidopsis plants lacking the oxidative signal-inducible1 (OXI1) protein kinase.
induction of Cu/Zn superoxide dismutases in Cu-exposed leaves regulated by OXI1 in a manner that involves fluctuations in the expression of miRNA398
Title: The role of the kinase OXI1 in cadmium- and copper-induced molecular responses in Arabidopsis thaliana.
Piriformospora indica-stimulated growth response is mediated by a pathway consisting of the PLD-PDK1-OXI1 cascade.
Title: The OXI1 kinase pathway mediates Piriformospora indica-induced growth promotion in Arabidopsis.
These results demonstrate that PTI1-4 signals via OXI1 and MPK6 signalling cascades.
Title: The Arabidopsis protein kinase Pto-interacting 1-4 is a common target of the oxidative signal-inducible 1 and mitogen-activated protein kinases.
Null oxi1 mutants are more susceptible to Pseudomonas syringae compared with the wild type.
Title: OXI1 protein kinase is required for plant immunity against Pseudomonas syringae in Arabidopsis.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_113431.6

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to hypoxia	HEP more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein

NP_189162.1

AGC2-1; FUNCTIONS IN: kinase activity; INVOLVED IN: protein amino acid phosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: hypocotyl, root, stamen, pollen tube; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), AGC-kinase, C-terminal (InterPro:IPR000961), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein (TAIR:AT4G13000.1); Has 87313 Blast hits to 84259 proteins in 2947 species: Archae - 68; Bacteria - 13079; Metazoa - 33183; Fungi - 11494; Plants - 12113; Viruses - 235; Other Eukaryotes - 17141 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9195334..9197126

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113431.6 → NP_189162.1 AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189162.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A1L4U5, Q9LSF1

UniProtKB/TrEMBL

A0A5S9XFM3

Conserved Domains (2) summary

smart00220
Location:18 → 329

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:13 → 354

PKc_like; Protein Kinases, catalytic domain