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PHP PLANT HOMOLOGOUS TO PARAFIBROMIN [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821831, updated on 18-Sep-2024

Summary

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Official Symbol
PHP
Official Full Name
PLANT HOMOLOGOUS TO PARAFIBROMIN
Primary source
TAIR:AT3G22590
Locus tag
AT3G22590
See related
Araport:AT3G22590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CDC73; PLANT HOMOLOGOUS TO PARAFIBROMIN
Summary
Encodes PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP), a homolog of human Paf1 Complex (Paf1C) subunit Parafibromin. Human Parafibromin assists in mediating output from the Wnt signaling pathway, and dysfunction of the encoding gene HRPT2 conditions specific cancer-related disease phenotypes. PHP resides in a ~670-kDa protein complex in nuclear extracts, and physically interacts with other known Paf1C-related proteins in vivo. Loss of PHP specifically conditioned accelerated phase transition from vegetative growth to flowering and resulted in misregulation of a very limited subset of genes that included the flowering repressor FLOWERING LOCUS C (FLC).
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Genomic context

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See PHP in Genome Data Viewer
Location:
chromosome: 3
Exon count:
3
Sequence:
Chromosome: 3; NC_003074.8 (8003898..8005902)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein Neighboring gene 20S proteasome beta subunit D1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor. Park S, et al. Plant Signal Behav, 2011 Aug. PMID 21720211, Free PMC Article
  2. The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin. Yu X, et al. Plant Physiol, 2010 Jul. PMID 20463090, Free PMC Article
  3. PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin. Park S, et al. Plant Physiol, 2010 Jun. PMID 20363855, Free PMC Article
  4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PHP is an accessory subunit of Paf1C that promotes proper regulation of genes within H3K27me3-enriched chromatin.
    Title: Potential role of Arabidopsis PHP as an accessory subunit of the PAF1 transcriptional cofactor.
  2. CDC73 is required for high levels of FLC expression in a subset of autonomous-pathway-mutant backgrounds and functions both to promote activating histone modifications (H3K4me3) as well as preventing repressive ones (e.g. H3K27me3). [CDC73]
    Title: The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin.
  3. PLANT HOMOLOGOUS TO PARAFIBROMIN represents the plant homolog of parafibromin, and interacts physically with other Paf1C components.
    Title: PLANT HOMOLOGOUS TO PARAFIBROMIN is a component of the PAF1 complex and assists in regulating expression of genes within H3K27ME3-enriched chromatin.
Submit: New GeneRIF Correction

General gene information

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NM_113158.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription elongation by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Cdc73/Paf1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of RNA polymerase I core factor complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
PLANT HOMOLOGOUS TO PARAFIBROMIN
NP_188898.1
  • PLANT HOMOLOGOUS TO PARAFIBROMIN (PHP); CONTAINS InterPro DOMAIN/s: RNA polymerase II accessory factor, Cdc73 (InterPro:IPR007852); Has 502 Blast hits to 395 proteins in 198 species: Archae - 0; Bacteria - 0; Metazoa - 257; Fungi - 127; Plants - 42; Viruses - 0; Other Eukaryotes - 76 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    8003898..8005902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_113158.3 → NP_188898.1  PLANT HOMOLOGOUS TO PARAFIBROMIN [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188898.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9LJ87
    UniProtKB/TrEMBL
    A0A178VJ60, A0A5S9XEY3
    Conserved Domains (2) summary
    COG5157
    Location:31 → 412
    CDC73; RNA polymerase II assessory factor [Transcription]
    pfam05179
    Location:252 → 407
    CDC73_C; RNA pol II accessory factor, Cdc73 family, C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LJ87.1

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