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PYRB PYRIMIDINE B [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821577, updated on 18-Sep-2024

Summary

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Official Symbol
PYRB
Official Full Name
PYRIMIDINE B
Primary source
TAIR:AT3G20330
Locus tag
AT3G20330
See related
Araport:AT3G20330
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
PYRIMIDINE B
Summary
encodes aspartate carbamoyltransferase catalyzing the second step in the de novo pyrimidine ribonucleotide biosynthesis
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Genomic context

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See PYRB in Genome Data Viewer
Location:
chromosome: 3
Exon count:
6
Sequence:
Chromosome: 3; NC_003074.8 (7089989..7092670, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ethylene response factor 7 Neighboring gene trigalactosyldiacylglycerol2 Neighboring gene protein expression protein Neighboring gene actin cytoskeleton-regulatory complex pan-like protein Neighboring gene TRAF-like family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and functional analysis of aspartate transcarbamoylase and role of de novo pyrimidine synthesis in regulation of growth and development in Arabidopsis. Chen CT, et al. Plant Physiol Biochem, 2008 Feb. PMID 18053734
  2. Heterospecific cloning of Arabidopsis thaliana cDNAs by direct complementation of pyrimidine auxotrophic mutants of Saccharomyces cerevisiae. I. Cloning and sequence analysis of two cDNAs catalysing the second, fifth and sixth steps of the de novo pyrimidine biosynthesis pathway. Nasr F, et al. Mol Gen Genet, 1994 Jul 8. PMID 8041358
  3. Effects of phosphate limitation on expression of genes involved in pyrimidine synthesis and salvaging in Arabidopsis. Hewitt MM, et al. Plant Physiol Biochem, 2005 Feb. PMID 15820655
  4. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
  5. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001338476.1
NM_112924.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables amino acid binding IEA
Inferred from Electronic Annotation
more info
  
enables aspartate carbamoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartate carbamoyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in 'de novo' UMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to phosphate starvation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within pyrimidine ribonucleotide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast stroma HDA PubMed 

General protein information

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Preferred Names
PYRIMIDINE B
NP_188668.1
  • PYRIMIDINE B (PYRB); FUNCTIONS IN: amino acid binding, protein binding, aspartate carbamoyltransferase activity, carboxyl- or carbamoyltransferase activity; INVOLVED IN: cellular response to phosphate starvation, pyrimidine ribonucleotide biosynthetic process, cellular amino acid metabolic process; LOCATED IN: chloroplast, chloroplast stroma; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding (InterPro:IPR006132), Aspartate/ornithine carbamoyltransferase (InterPro:IPR006130), Aspartate carbamoyltransferase, eukaryotic (InterPro:IPR002082), Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain (InterPro:IPR006131); BEST Arabidopsis thaliana protein match is: ornithine carbamoyltransferase (TAIR:AT1G75330.1); Has 16843 Blast hits to 16841 proteins in 2894 species: Archae - 534; Bacteria - 10902; Metazoa - 218; Fungi - 284; Plants - 116; Viruses - 6; Other Eukaryotes - 4783 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    7089989..7092670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112924.4 → NP_188668.1  PYRIMIDINE B [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188668.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49077, Q683J9, Q94A47, Q9LTR1
    UniProtKB/TrEMBL
    A0A178VJE3, A0A654FHJ6
    Conserved Domains (1) summary
    PLN02527
    Location:85 → 390
    PLN02527; aspartate carbamoyltransferase

  2. NM_001338476.1 → NP_001326915.1  PYRIMIDINE B [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P49077, Q683J9, Q94A47, Q9LTR1
    UniProtKB/TrEMBL
    A0A178VJE3, A0A654FHJ6
    Conserved Domains (1) summary
    PLN02527
    Location:85 → 390
    PLN02527; aspartate carbamoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49077.2

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