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VRN1 AP2/B3-like transcriptional factor family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821432, updated on 18-Sep-2024

Summary

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Official Symbol
VRN1
Official Full Name
AP2/B3-like transcriptional factor family protein
Primary source
TAIR:AT3G18990
Locus tag
AT3G18990
See related
Araport:AT3G18990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
REDUCED VERNALIZATION RESPONSE 1; REM39; REPRODUCTIVE MERISTEM 39
Summary
Required for vernalization. Essential for the complete repression of FLC in vernalized plants. Required for the methylation of histone H3
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Genomic context

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See VRN1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (6548127..6552055, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene AP2/B3-like transcriptional factor family protein Neighboring gene mitochondrial editing factor 20 Neighboring gene EIN2 targeting protein1 Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene ncRNA Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness. Wang Y, et al. J Mol Biol, 2021 Nov 5. PMID 34571015
  2. The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface. King GJ, et al. J Biol Chem, 2013 Feb 1. PMID 23255593, Free PMC Article
  3. Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1(208-341) from Arabidopsis thaliana. King G, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2009 Mar 1. PMID 19255487, Free PMC Article
  4. Multiple roles of Arabidopsis VRN1 in vernalization and flowering time control. Levy YY, et al. Science, 2002 Jul 12. PMID 12114624
  5. Arabidopsis mutants showing an altered response to vernalization. Chandler J, et al. Plant J, 1996 Oct. PMID 8998499

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness.
    Title: Charge Segregation in the Intrinsically Disordered Region Governs VRN1 and DNA Liquid-like Phase Separation Robustness.
  2. Although VRN1 is sequence-nonspecific in DNA binding, it has a defined DNA-binding surface.
    Title: The Arabidopsis B3 domain protein VERNALIZATION1 (VRN1) is involved in processes essential for development, with structural and mutational studies revealing its DNA-binding surface.
  3. Preliminary X-ray diffraction data analysis revealed that the VRN1(208-341) crystal diffracted to 2.1 A.
    Title: Expression, purification and preliminary X-ray diffraction studies of VERNALIZATION1(208-341) from Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_112785.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vernalization response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AP2/B3-like transcriptional factor family protein
NP_188529.2
  • REDUCED VERNALIZATION RESPONSE 1 (VRN1); CONTAINS InterPro DOMAIN/s: Transcriptional factor B3 (InterPro:IPR003340); BEST Arabidopsis thaliana protein match is: related to vernalization1 1 (TAIR:AT1G49480.1); Has 683 Blast hits to 597 proteins in 20 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 682; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    6548127..6552055 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001338374.1 → NP_001326749.1  AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1I9LQ83, A0A654F8L2

  2. NM_112785.5 → NP_188529.2  AP2/B3-like transcriptional factor family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188529.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8L3W1, Q9LJ67
    UniProtKB/TrEMBL
    A0A178VIS1, A0A5S9XF37, A0A654F8L2
    Conserved Domains (2) summary
    cd10017
    Location:5 → 96
    B3_DNA; Plant-specific B3-DNA binding domain
    pfam02362
    Location:244 → 338
    B3; B3 DNA binding domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8L3W1.1

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