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VTC4 Inositol monophosphatase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821206, updated on 18-Sep-2024

Summary

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Official Symbol
VTC4
Official Full Name
Inositol monophosphatase family protein
Primary source
TAIR:AT3G02870
Locus tag
AT3G02870
See related
Araport:AT3G02870
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F13E7.19; F13E7_19
Summary
Encodes a L-galactose-1-phosphate phosphatase, involved in ascorbate biosynthesis.
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Genomic context

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See VTC4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Sequence:
Chromosome: 3; NC_003074.8 (627512..629925, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ARM repeat superfamily protein Neighboring gene STELAR K+ outward rectifier Neighboring gene zinc ion binding protein Neighboring gene ncRNA Neighboring gene Peptidase M20/M25/M40 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis thaliana VTC4 encodes L-galactose-1-P phosphatase, a plant ascorbic acid biosynthetic enzyme. Conklin PL, et al. J Biol Chem, 2006 Jun 9. PMID 16595667
  2. A highly specific L-galactose-1-phosphate phosphatase on the path to ascorbate biosynthesis. Laing WA, et al. Proc Natl Acad Sci U S A, 2004 Nov 30. PMID 15550539, Free PMC Article
  3. VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. Torabinejad J, et al. Plant Physiol, 2009 Jun. PMID 19339506, Free PMC Article
  4. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
  5. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VTC4 is a bifunctional enzyme that impacts both myoinositol and ascorbate synthesis pathways.
    Title: VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001035549.1
NM_001125086.1
NM_111155.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables L-galactose-1-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-galactose-1-phosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables inositol monophosphate 1-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables inositol monophosphate 1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 3-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol monophosphate 4-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within inositol biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to cold IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
Inositol monophosphatase family protein
NP_001030626.1
  • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001118558.1
  • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, Lithium-sensitive (InterPro:IPR020552), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_186936.1
  • VTC4; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, L-galactose-1-phosphate phosphatase activity, inositol or phosphatidylinositol phosphatase activity, inositol-1(or 4)-monophosphatase activity; INVOLVED IN: sulfur metabolic process, L-ascorbic acid biosynthetic process, response to karrikin, response to cold, inositol biosynthetic process; LOCATED IN: plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase, conserved site (InterPro:IPR020550), Inositol monophosphatase (InterPro:IPR000760), Inositol monophosphatase, metal-binding site (InterPro:IPR020583), Inositol monophosphatase, Lithium-sensitive (InterPro:IPR020552); BEST Arabidopsis thaliana protein match is: myo-inositol monophosphatase like 1 (TAIR:AT1G31190.1); Has 16249 Blast hits to 16237 proteins in 2366 species: Archae - 250; Bacteria - 8645; Metazoa - 648; Fungi - 322; Plants - 290; Viruses - 0; Other Eukaryotes - 6094 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    627512..629925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111155.3 → NP_186936.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_186936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LE95, Q9M8S8
    UniProtKB/TrEMBL
    A0A178V8V9, A0A5S9X8K5, A0A7G2EFC4
    Conserved Domains (1) summary
    PLN02553
    Location:1 → 269
    PLN02553; inositol-phosphate phosphatase

  2. NM_001125086.1 → NP_001118558.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118558.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2EFC4, B3H749
    Conserved Domains (1) summary
    PLN02553
    Location:3 → 266
    PLN02553; inositol-phosphate phosphatase

  3. NM_001035549.1 → NP_001030626.1  Inositol monophosphatase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030626.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2EFC4, F4IYH1
    Conserved Domains (1) summary
    PLN02553
    Location:1 → 267
    PLN02553; inositol-phosphate phosphatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9M8S8.1

Gene LinkOut

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