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MTM1 Myotubularin-like phosphatases II superfamily [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820220, updated on 18-Sep-2024

Summary

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Official Symbol
MTM1
Official Full Name
Myotubularin-like phosphatases II superfamily
Primary source
TAIR:AT3G10550
Locus tag
AT3G10550
See related
Araport:AT3G10550
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Arabidopsis thaliana myotubularin 1; AtMTM1; myotubularin 1
Summary
Has 3'-phosphatase activity against both phosphatidylinositol-3,5-bisphosphate (PtdIns3,5P2) and Phosphatidylinositol-3-phosphate (PtdIns3P). The in vitro activity was higher with PtdIns3,5P2 than with PtdIns3P.
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Genomic context

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See MTM1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
19
Sequence:
Chromosome: 3; NC_003074.8 (3292890..3298621, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene LOSS OF GIANT CELLS FROM ORGANS Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene 3-phosphoinositide-dependent protein kinase Neighboring gene Cytochrome P450 superfamily protein Neighboring gene cytochrome P450, family 77, subfamily A, polypeptide 6

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family. Ding Y, et al. Plant J, 2012 Jun. PMID 22324391
  2. The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought. Ding Y, et al. Plant Signal Behav, 2009 Nov. PMID 19901554, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AtMTM1 encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins. AtMTM1 and the Arabidopsis chromatin modifier ATX1, co-regulate overlapping set of genes under drought conditions. [AtMTM1]
    Title: The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
  2. AtMTM1 is involved in elevating the cellular level of phosphatidylinositol 5-phosphate in response to dehydration stress.
    Title: Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family.
  3. study reports that At3g10550, encodes a phosphoinositide 3'-phosphatase related to the animal myotubularins (AtMTM1); identifed an overlapping set of genes co-regulated by ATX1 and AtMTM under drought conditions
    Title: The Arabidopsis chromatin modifier ATX1, the myotubularin-like AtMTM and the response to drought.
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General gene information

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Homology

NM_111891.7

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-3-phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Myotubularin-like phosphatases II superfamily
NP_187666.5
  • Myotubularin-like phosphatases II superfamily; FUNCTIONS IN: phosphatidylinositol-3-phosphatase activity, phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity; INVOLVED IN: dephosphorylation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Protein-tyrosine phosphatase, active site (InterPro:IPR016130), Myotubularin phosphatase (InterPro:IPR017906), GRAM (InterPro:IPR004182), Myotubularin-related (InterPro:IPR010569); BEST Arabidopsis thaliana protein match is: Myotubularin-like phosphatases II superfamily (TAIR:AT5G04540.1); Has 1697 Blast hits to 1550 proteins in 179 species: Archae - 0; Bacteria - 0; Metazoa - 1273; Fungi - 128; Plants - 40; Viruses - 0; Other Eukaryotes - 256 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    3292890..3298621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111891.7 → NP_187666.5  Myotubularin-like phosphatases II superfamily [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187666.5

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4J3T8, Q84W79, Q9CAF1, Q9LPP2
    UniProtKB/TrEMBL
    A0A178V871, A0A5S9XAT2, A0A7G2EJV0
    Conserved Domains (2) summary
    smart00568
    Location:52 → 111
    GRAM; domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins
    pfam06602
    Location:218 → 591
    Myotub-related; Myotubularin-like phosphatase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F4J3T8.1

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