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APX2 ascorbate peroxidase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820121, updated on 18-Sep-2024

Summary

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Official Symbol
APX2
Official Full Name
ascorbate peroxidase 2
Primary source
TAIR:AT3G09640
Locus tag
AT3G09640
See related
Araport:AT3G09640
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
APX1B; ASCORBATE PEROXIDASE 1B; ascorbate peroxidase 2; CS2
Summary
Encodes a cytosolic ascorbate peroxidase APX2. Ascorbate peroxidases are enzymes that scavenge hydrogen peroxide in plant cells. Eight types of APX have been described for Arabidopsis: three cytosolic (APX1, APX2, APX6), two chloroplastic types (stromal sAPX, thylakoid tAPX), and three microsomal (APX3, APX4, APX5) isoforms.
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Genomic context

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See APX2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (2956156..2958330)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene Ribosomal protein L4/L1 family Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene minichromosome maintenance 8 Neighboring gene Tudor/PWWP/MBT superfamily protein Neighboring gene Ribosomal protein S12/S23 family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2. Suzuki N, et al. J Exp Bot, 2013 Jan. PMID 23183257, Free PMC Article
  2. A mutation affecting ASCORBATE PEROXIDASE 2 gene expression reveals a link between responses to high light and drought tolerance. Rossel JB, et al. Plant Cell Environ, 2006 Feb. PMID 17080642
  3. Influence of salicylic acid on H2O2 production, oxidative stress, and H2O2-metabolizing enzymes. Salicylic acid-mediated oxidative damage requires H2O2. Rao MV, et al. Plant Physiol, 1997 Sep. PMID 9306697, Free PMC Article
  4. Photosynthetic electron transport regulates the expression of cytosolic ascorbate peroxidase genes in Arabidopsis during excess light stress. Karpinski S, et al. Plant Cell, 1997 Apr. PMID 9144965, Free PMC Article
  5. Proteome analysis of peroxisomes from dark-treated senescent Arabidopsis leaves. Pan R, et al. J Integr Plant Biol, 2018 Nov. PMID 29877633

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Deficiency in APX2 resulted in a decreased tolerance to light stress, as well as an enhanced tolerance to salinity and oxidative stresses.
    Title: Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2.
  2. The drought tolerant alx8 mutant provides evidence for common steps in drought and high light stress response pathways.
    Title: A mutation affecting ASCORBATE PEROXIDASE 2 gene expression reveals a link between responses to high light and drought tolerance.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001035587.3
NM_111798.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables L-ascorbate peroxidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to oxidative stress IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
ascorbate peroxidase 2
NP_001030664.1
  • ascorbate peroxidase 2 (APX2); CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 1 (TAIR:AT1G07890.8); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_187575.2
  • ascorbate peroxidase 2 (APX2); CONTAINS InterPro DOMAIN/s: Haem peroxidase (InterPro:IPR010255), Plant ascorbate peroxidase (InterPro:IPR002207), Peroxidases heam-ligand binding site (InterPro:IPR019793), Haem peroxidase, plant/fungal/bacterial (InterPro:IPR002016), Peroxidase, active site (InterPro:IPR019794); BEST Arabidopsis thaliana protein match is: ascorbate peroxidase 1 (TAIR:AT1G07890.8); Has 8439 Blast hits to 8256 proteins in 1276 species: Archae - 55; Bacteria - 2395; Metazoa - 20; Fungi - 832; Plants - 3373; Viruses - 0; Other Eukaryotes - 1764 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2956156..2958330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111798.4 → NP_187575.2  ascorbate peroxidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187575.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1PER6, Q39006, Q67XB1, Q9SF39
    UniProtKB/TrEMBL
    A0A178VH43, A0A5S9XBP2, A0MEV1
    Conserved Domains (1) summary
    cl00196
    Location:1 → 251
    plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases

  2. NM_001035587.3 → NP_001030664.1  ascorbate peroxidase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030664.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q1PER6, Q39006, Q67XB1, Q9SF39
    UniProtKB/TrEMBL
    A0A178VH43, A0A5S9XBP2, A0MEV1
    Conserved Domains (1) summary
    cl00196
    Location:1 → 251
    plant_peroxidase_like; Heme-dependent peroxidases similar to plant peroxidases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q1PER6.3

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