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Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81921, updated on 10-Jul-2024

Summary

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Official Symbol
Sh3gl3provided by RGD
Official Full Name
SH3 domain containing GRB2 like 3, endophilin A3provided by RGD
Primary source
RGD:620578
See related
EnsemblRapid:ENSRNOG00000019776 AllianceGenome:RGD:620578
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SH3P13; Sh3d2c1
Summary
Enables protein C-terminus binding activity. Involved in negative regulation of clathrin-dependent endocytosis and positive regulation of neuron differentiation. Located in acrosomal vesicle; early endosome; and presynapse. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and postsynaptic endosome. Orthologous to human SH3GL3 (SH3 domain containing GRB2 like 3, endophilin A3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 203.2), Brain (RPKM 119.5) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sh3gl3 in Genome Data Viewer
Location:
1q31
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (145533728..145664881)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (136124500..136255669)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (144069641..144200402)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102556513 Neighboring gene basonuclin zinc finger protein 1 Neighboring gene uncharacterized LOC134483749 Neighboring gene uncharacterized LOC134483750 Neighboring gene U6 snRNA-associated Sm-like protein LSm5 Neighboring gene ADAMTS-like 3 Neighboring gene stabilizer of axonemal microtubules 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of rtSH3p13 gene encoding a development protein involved in vesicular traffic in spermiogenesis. Qiao Y, et al. Cell Res, 2004 Jun. PMID 15225413
  2. Inhibitory role of endophilin 3 in receptor-mediated endocytosis. Sugiura H, et al. J Biol Chem, 2004 May 28. PMID 15066995
  3. Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation. De Gois S, et al. Cell Mol Neurobiol, 2006 Jul-Aug. PMID 16710756
  4. Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I. Tian Q, et al. Neurosci Bull, 2012 Oct. PMID 22961472, Free PMC Article
  5. Distinct endocytic pathways control the rate and extent of synaptic vesicle protein recycling. Voglmaier SM, et al. Neuron, 2006 Jul 6. PMID 16815333

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endophilin III binding to N-type Ca2+ channel carboxy-terminal fragments is Ca2+-independent in clathrin-mediated endocytosis.
    Title: Endophilin isoforms have distinct characteristics in interactions with N-type Ca2+ channels and dynamin I.
  2. VGLUT1 and endophilins 1 and 3 may interact to play an important role affecting the vesicular sequestration and synaptic release of glutamate.
    Title: Identification of endophilins 1 and 3 as selective binding partners for VGLUT1 and their co-localization in neocortical glutamatergic synapses: implications for vesicular glutamate transporter trafficking and excitatory vesicle formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle uncoating IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle uncoating ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density, intracellular component IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynaptic endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
endophilin-A3
Names
SH3 domain protein 2 C1
SH3 domain protein 2C
SH3 domain-containing GRB2-like 3
SH3 domain-containing GRB2-like protein 3
SH3-domain GRB2-like 3
endophilin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001414376.1 → NP_001401305.1  endophilin-A3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    O35104, O35180
    UniProtKB/TrEMBL
    A6JCJ2, A6JCJ3
    Related
    ENSRNOP00000095576.1, ENSRNOT00000096616.2

  2. NM_031238.3 → NP_112517.1  endophilin-A3 isoform 2

    See identical proteins and their annotated locations for NP_112517.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8L2R634, A0A9K3Y7M5, F1M8F8, Q9JKT0
    Related
    ENSRNOP00000026870.5, ENSRNOT00000026870.8
    Conserved Domains (2) summary
    cd11803
    Location:253 → 307
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
    cl12013
    Location:1 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    145533728..145664881
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063275380.1 → XP_063131450.1  endophilin-A3 isoform X8

  2. XM_063275376.1 → XP_063131446.1  endophilin-A3 isoform X6

  3. XM_063275373.1 → XP_063131443.1  endophilin-A3 isoform X4

    UniProtKB/TrEMBL
    A6JCJ3

  4. XM_063275370.1 → XP_063131440.1  endophilin-A3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AFE3, A0A8L2R634
    Related
    ENSRNOP00000091889.1, ENSRNOT00000109733.2

  5. XM_063275385.1 → XP_063131455.1  endophilin-A3 isoform X9

  6. XM_063275378.1 → XP_063131448.1  endophilin-A3 isoform X7

  7. XM_006229481.5 → XP_006229543.1  endophilin-A3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6APE5, A0A8L2R634
    Related
    ENSRNOP00000095776.1, ENSRNOT00000119037.2
    Conserved Domains (2) summary
    cd07615
    Location:23 → 245
    BAR_Endophilin_A3; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A3
    cd11803
    Location:286 → 340
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

  8. XM_006229483.5 → XP_006229545.1  endophilin-A3 isoform X3

    See identical proteins and their annotated locations for XP_006229545.1

    UniProtKB/TrEMBL
    A0A8L2R634, A0A9K3Y7M5, F1M8F8, Q9JKT0
    Conserved Domains (2) summary
    cd11803
    Location:253 → 307
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
    cl12013
    Location:1 → 212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_006229485.3 → XP_006229547.1  endophilin-A3 isoform X5

    See identical proteins and their annotated locations for XP_006229547.1

    UniProtKB/TrEMBL
    A0A8L2R634
    Related
    ENSRNOP00000072673.2, ENSRNOT00000079989.3
    Conserved Domains (2) summary
    cd11803
    Location:219 → 273
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
    cl12013
    Location:1 → 178
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  10. XM_006229486.4 → XP_006229548.1  endophilin-A3 isoform X10

    Conserved Domains (2) summary
    cd11803
    Location:165 → 219
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A
    cl12013
    Location:1 → 124
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  11. XM_063275400.1 → XP_063131470.1  endophilin-A3 isoform X10

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35180.2 GenPept UniProtKB/Swiss-Prot:O35180

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