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Cacng7 calcium channel, voltage-dependent, gamma subunit 7 [ Mus musculus (house mouse) ]

Gene ID: 81904, updated on 10-Oct-2024

Summary

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Official Symbol
Cacng7provided by MGI
Official Full Name
calcium channel, voltage-dependent, gamma subunit 7provided by MGI
Primary source
MGI:MGI:1932374
See related
Ensembl:ENSMUSG00000069806 AllianceGenome:MGI:1932374
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable calcium channel regulator activity and voltage-gated calcium channel activity. Involved in neurotransmitter receptor localization to postsynaptic specialization membrane. Located in glutamatergic synapse. Is expressed in central nervous system; genitourinary system; and retina. Orthologous to human CACNG7 (calcium voltage-gated channel auxiliary subunit gamma 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 41.3), frontal lobe adult (RPKM 39.7) and 16 other tissues See more
Orthologs
human all
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Genomic context

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See Cacng7 in Genome Data Viewer
Location:
7 A1; 7 1.95 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3381341..3416737)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3332027..3368221)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E10422 Neighboring gene myeloid-associated differentiation marker Neighboring gene protein kinase C, gamma Neighboring gene STARR-seq mESC enhancer starr_17899 Neighboring gene STARR-seq mESC enhancer starr_17900 Neighboring gene predicted gene 9567 Neighboring gene calcium channel, voltage-dependent, gamma subunit 8 Neighboring gene microRNA 935

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior. Yamazaki M, et al. Proc Natl Acad Sci U S A, 2015 Jan 27. PMID 25583485, Free PMC Article
  2. TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs. Studniarczyk D, et al. Nat Neurosci, 2013 Sep. PMID 23872597, Free PMC Article
  3. TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum. Yamazaki M, et al. Eur J Neurosci, 2010 Jun. PMID 20529126
  4. New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors. Kato AS, et al. J Neurosci, 2007 May 2. PMID 17475805, Free PMC Article
  5. The novel product of a five-exon stargazin-related gene abolishes Ca(V)2.2 calcium channel expression. Moss FJ, et al. EMBO J, 2002 Apr 2. PMID 11927536, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Thus, gamma-7 is capable of supporting a component of excitatory transmission in PCs, sufficient to maintain essentially normal motor behavior, in the absence of gamma-2.
    Title: Relative contribution of TARPs γ-2 and γ-7 to cerebellar excitatory synaptic transmission and motor behavior.
  2. The results of this study suggested that TARPed synaptic receptors in granule cells require both gamma-2 and gamma-7 and reveal an unexpected basis for the loss of AMPAR-mediated transmission in stargazer mice.
    Title: TARP γ-7 selectively enhances synaptic expression of calcium-permeable AMPARs.
  3. Results suggest that TARPs gamma-2 and gamma-7 cooperatively promote synaptic expression of cerebellar AMPA receptors, and the latter also promotes glial expression.
    Title: TARPs gamma-2 and gamma-7 are essential for AMPA receptor expression in the cerebellum.
  4. TARP gamma-7 causes AMPA receptors to "resensitize" upon continued glutamate application.
    Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.
  5. Gamma-7 is a new member of the transmembrane AMPA receptor regulatory protein (TARP) family that can differentially influence AMPA receptors in cerebellar neurons. (TARP gamma-7)
    Title: New transmembrane AMPA receptor regulatory protein isoform, gamma-7, differentially regulates AMPA receptors.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables calcium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in calcium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in neurotransmitter receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurotransmitter receptor transport, postsynaptic endosome to lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic transmission, glutamatergic IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of AMPA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mRNA stability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transmission of nerve impulse IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of AMPA glutamate receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of AMPA glutamate receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of AMPA glutamate receptor complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of L-type voltage-gated calcium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of L-type voltage-gated calcium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cerebellar mossy fiber IEA
Inferred from Electronic Annotation
more info
  
located_in cerebellar mossy fiber ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
voltage-dependent calcium channel gamma-7 subunit
Names
TARP gamma-7
neuronal voltage-gated calcium channel gamma-7 subunit
transmembrane AMPAR regulatory protein gamma-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420208.1 → NP_001407137.1  voltage-dependent calcium channel gamma-7 subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC217111
    UniProtKB/Swiss-Prot
    P62956
    UniProtKB/TrEMBL
    B9EJ14

  2. NM_001420209.1 → NP_001407138.1  voltage-dependent calcium channel gamma-7 subunit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC217111
    UniProtKB/Swiss-Prot
    P62956
    UniProtKB/TrEMBL
    B9EJ14

  3. NM_001420210.1 → NP_001407139.1  voltage-dependent calcium channel gamma-7 subunit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC217111

  4. NM_133189.5 → NP_573452.3  voltage-dependent calcium channel gamma-7 subunit isoform 1

    See identical proteins and their annotated locations for NP_573452.3

    Status: VALIDATED

    Source sequence(s)
    AC217111
    Consensus CDS
    CCDS39725.1
    UniProtKB/Swiss-Prot
    P62956
    UniProtKB/TrEMBL
    B9EJ14, Q8C061
    Related
    ENSMUSP00000090567.5, ENSMUST00000092891.6
    Conserved Domains (1) summary
    cl21598
    Location:16 → 195
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3381341..3416737
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62956.1 GenPept UniProtKB/Swiss-Prot:P62956

Gene LinkOut

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