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NUDX23 nudix hydrolase homolog 23 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818807, updated on 18-Sep-2024

Summary

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Official Symbol
NUDX23
Official Full Name
nudix hydrolase homolog 23
Primary source
TAIR:AT2G42070
Locus tag
AT2G42070
See related
Araport:AT2G42070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS THALIANA NUDIX HYDROLASE HOMOLOG 23; ATNUDT23; ATNUDX23; nudix hydrolase homolog 23; T6D20.4; T6D20_4
Summary
Encodes a plastid-localized Nudix hydrolase that has FAD pyrophosphohydrolase activity. Negative feedback regulation of the metabolism of flavins through the hydrolysis of FAD by AtNUDX23 in plastids is involved in the flavin homeostasis in plant cells.
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Genomic context

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See NUDX23 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (17549091..17551364, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene WRC protein Neighboring gene pseudo Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene DnaJ domain protein Neighboring gene Chaperone DnaJ-domain superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An Arabidopsis FAD pyrophosphohydrolase, AtNUDX23, is involved in flavin homeostasis. Maruta T, et al. Plant Cell Physiol, 2012 Jun. PMID 22505691
  2. Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis. Ogawa T, et al. Plant Physiol, 2008 Nov. PMID 18815383, Free PMC Article
  3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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NM_001336950.1
NM_129770.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ADP-ribose diphosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD diphosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flavin-containing compound metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to light stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
nudix hydrolase homolog 23
NP_565965.1
  • nudix hydrolase homolog 23 (NUDX23); CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase (InterPro:IPR020476), NUDIX hydrolase, conserved site (InterPro:IPR020084), NUDIX hydrolase domain (InterPro:IPR000086); Has 7171 Blast hits to 7171 proteins in 1678 species: Archae - 149; Bacteria - 5807; Metazoa - 107; Fungi - 42; Plants - 74; Viruses - 1; Other Eukaryotes - 991 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17549091..17551364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129770.4 → NP_565965.1  nudix hydrolase homolog 23 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565965.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P93740, Q1ECD1, Q8LAH1
    UniProtKB/TrEMBL
    A0A178VYY0, A0A5S9X685, A0A654F6E1
    Conserved Domains (2) summary
    cd04511
    Location:110 → 239
    Nudix_Hydrolase_4; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
    pfam14803
    Location:86 → 116
    Nudix_N_2; Nudix N-terminal

  2. NM_001336950.1 → NP_001324265.1  nudix hydrolase homolog 23 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8AZL7, A0A5S9X685, A0A654F6E1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P93740.2

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