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CXXS2 C-terminal cysteine residue is changed to a serine 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818676, updated on 18-Sep-2024

Summary

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Official Symbol
CXXS2
Official Full Name
C-terminal cysteine residue is changed to a serine 2
Primary source
TAIR:AT2G40790
Locus tag
AT2G40790
See related
Araport:AT2G40790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCXXS2; C-terminal cysteine residue is changed to a serine 2; T7D17.3; T7D17_3
Summary
Encodes a monocysteinic thioredoxin, thioredoxin in which the second cysteine of the redox site is replaced by a serine, with low disulfide reductase but efficient disulfide isomerase activity. It contains a large N-terminal extension with respect to the dicysteinic thioredoxins that is enriched with 8 cysteines and positively charged residues.
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Genomic context

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See CXXS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
5
Sequence:
Chromosome: 2; NC_003071.7 (17022952..17024301, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene RING-finger, DEAD-like helicase, PHD and SNF2 domain-containing protein Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene import inner membrane translocase subunit Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AtCXXS: atypical members of the Arabidopsis thaliana thioredoxin h family with a remarkably high disulfide isomerase activity. Serrato AJ, et al. Physiol Plant, 2008 Jul. PMID 18384502
  2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

General gene information

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Homology

NM_001336864.1
NM_129642.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
NOT involved_in protein deglutathionylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
C-terminal cysteine residue is changed to a serine 2
NP_001318396.1
  • C-terminal cysteine residue is changed to a serine 2 (CXXS2); FUNCTIONS IN: protein disulfide isomerase activity; INVOLVED IN: N-terminal protein myristoylation, protein thiol-disulfide exchange; LOCATED IN: cytosol; EXPRESSED IN: 9 plant structures; EXPRESSED DURING: L mature pollen stage, M germinated pollen stage, 4 anthesis; CONTAINS InterPro DOMAIN/s: Thioredoxin fold (InterPro:IPR012335), Thioredoxin, core (InterPro:IPR015467), Thioredoxin-like (InterPro:IPR017936), Thioredoxin domain (InterPro:IPR013766), Thioredoxin-like fold (InterPro:IPR012336); BEST Arabidopsis thaliana protein match is: Thioredoxin superfamily protein (TAIR:AT3G56420.1); Has 10001 Blast hits to 9985 proteins in 2467 species: Archae - 182; Bacteria - 5375; Metazoa - 1057; Fungi - 645; Plants - 1031; Viruses - 5; Other Eukaryotes - 1706 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17022952..17024301 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336864.1 → NP_001318396.1  C-terminal cysteine residue is changed to a serine 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38878, Q8GXV2
    UniProtKB/TrEMBL
    A0A5S9X5U7, A0A654F0P6, A0A7G2EJ73
    Conserved Domains (1) summary
    cd02947
    Location:49 → 138
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...

  2. NM_129642.4 → NP_181611.2  C-terminal cysteine residue is changed to a serine 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181611.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38878, Q8GXV2
    UniProtKB/TrEMBL
    A0A5S9X5U7, A0A654F0P6, A0A7G2EJ73
    Conserved Domains (1) summary
    cd02947
    Location:49 → 138
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8GXV2.1

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