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LEW3 UDP-Glycosyltransferase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818610, updated on 18-Sep-2024

Summary

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Official Symbol
LEW3
Official Full Name
UDP-Glycosyltransferase superfamily protein
Primary source
TAIR:AT2G40190
Locus tag
AT2G40190
See related
Araport:AT2G40190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
LEAF WILTING 3; T7M7.7; T7M7_7
Summary
Encodes a putative alpha-1,2-mannosyltransferase in N-linked glycoprotein (homologous to yeast ALG11). Plays vital roles in cell-wall biosynthesis and abiotic stress response. Located in endoplasmic reticulum membrane.
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Genomic context

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See LEW3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (16785173..16787590)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Stress induced protein Neighboring gene phosphatase 2C5 Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene Ribosomal protein L41 family Neighboring gene AGAMOUS-like 48

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana. Zhang M, et al. Plant J, 2009 Dec. PMID 19732381
  2. A light-sensitive mutation in Arabidopsis LEW3 reveals the important role of N-glycosylation in root growth and development. Manzano C, et al. J Exp Bot, 2017 Nov 2. PMID 29106622
  3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Positional cloning determined that lrg1 affects an alpha-1,2-mannosyltransferase gene, LEW3, involved in protein N-glycosylation. The lrg1 mutation causes a synonymous substitution that alters the correct splicing of the fourth intron in LEW3, causing a mix of wild-type and truncated protein. LRG1 RNA missplicing in roots and short root phenotypes in lrg1 are light-intensity dependent.
    Title: A light-sensitive mutation in Arabidopsis LEW3 reveals the important role of N-glycosylation in root growth and development.
  2. The lew3 mutation reduces protein glycosylation, impairs cellulose synthesis, and results in xylem collapse. lew3 mutants are more sensitive to salt stress and transpire less water than the wild-type.
    Title: LEW3, encoding a putative alpha-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana.
Submit: New GeneRIF Correction

General gene information

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NM_129577.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in dolichol-linked oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within plant-type cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
UDP-Glycosyltransferase superfamily protein
NP_181548.2
  • LEAF WILTING 3 (LEW3); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, group 1 (InterPro:IPR001296); BEST Arabidopsis thaliana protein match is: UDP-Glycosyltransferase superfamily protein (TAIR:AT1G78800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16785173..16787590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129577.5 → NP_181548.2  UDP-Glycosyltransferase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181548.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F4IH01, Q0WT32, Q7DNH4, Q9XEE9
    UniProtKB/TrEMBL
    A0A178VPQ2, A0A384LKU0, A0A5S9X5N1, W8PUX5
    Conserved Domains (1) summary
    PLN02949
    Location:1 → 463
    PLN02949; transferase, transferring glycosyl groups
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XEE9.2

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