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CYT1 Glucose-1-phosphate adenylyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818562, updated on 18-Sep-2024

Summary

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Official Symbol
CYT1
Official Full Name
Glucose-1-phosphate adenylyltransferase family protein
Primary source
TAIR:AT2G39770
Locus tag
AT2G39770
See related
Araport:AT2G39770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CYTOKINESIS DEFECTIVE 1; EMB101; EMBRYO DEFECTIVE 101; GDP-MANNOSE PYROPHOSPHORYLASE 1; GMP1; SENSITIVE TO OZONE 1; SOZ1; T5I7.7; T5I7_7; VITAMIN C DEFECTIVE 1; VTC1
Summary
Encodes a GDP-mannose pyrophosphorylase/ mannose-1-pyrophosphatase. This enzyme provides GDP-mannose, which is used for cell wall carbohydrate biosynthesis and protein glycosylation as well as for ascorbate (vitamin C) biosynthesis. Mutations in this gene confer hypersensitivity to NH4+.
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Genomic context

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See CYT1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (16588556..16591032)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BTB/POZ/MATH-domains containing protein Neighboring gene ncRNA Neighboring gene ribonuclease 2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1. Zhao S, et al. Acta Crystallogr F Struct Biol Commun, 2016 Oct 1. PMID 27710946, Free PMC Article
  2. A mutation in GDP-mannose pyrophosphorylase causes conditional hypersensitivity to ammonium, resulting in Arabidopsis root growth inhibition, altered ammonium metabolism, and hormone homeostasis. Barth C, et al. J Exp Bot, 2010. PMID 20007685, Free PMC Article
  3. Increased sensitivity to salt stress in an ascorbate-deficient Arabidopsis mutant. Huang C, et al. J Exp Bot, 2005 Dec. PMID 16263910
  4. Arabidopsis cyt1 mutants are deficient in a mannose-1-phosphate guanylyltransferase and point to a requirement of N-linked glycosylation for cellulose biosynthesis. Lukowitz W, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226227, Free PMC Article
  5. Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis. Conklin PL, et al. Proc Natl Acad Sci U S A, 1999 Mar 30. PMID 10097187, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1 have been described.
    Title: Expression and crystallographic studies of the Arabidopsis thaliana GDP-D-mannose pyrophosphorylase VTC1.
  2. Data reveal that the 27th amino acid of VTC1 confers a key regulation in the interaction with CSN5B and AsA biosynthesis, as well as in Arabidopsis seedling growth.
    Title: D27E mutation of VTC1 impairs the interaction with CSN5B and enhances ascorbic acid biosynthesis and seedling growth in Arabidopsis.
  3. VTC1 is degraded in the dark through the 26S proteasome pathway, and this degradation requires CSN5B.
    Title: Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis.
  4. Arabidopsis vtc1 and vtc2 mutants, that have low levels of ascorbate, were more susceptible to Alternaria brassicicola.
    Title: Metabolite profiling of Arabidopsis inoculated with Alternaria brassicicola reveals that ascorbate reduces disease severity.
  5. A mutation in vtc1 causes hypersensitivity to ammonium, resulting in root growth inhibition, altered ammonium metabolism, and hormone homeostasis.
    Title: A mutation in GDP-mannose pyrophosphorylase causes conditional hypersensitivity to ammonium, resulting in Arabidopsis root growth inhibition, altered ammonium metabolism, and hormone homeostasis.
  6. Programmed cell death symptoms such as nuclear chromatin condensation, the presence of multivesicular bodies, and extensive degradation and disorganization of the grana stacks were observed in 10-week-old vtc1 leaves.
    Title: Modulation of plant morphology, root architecture, and cell structure by low vitamin C in Arabidopsis thaliana.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001202784.1
NM_001336797.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables mannose-1-phosphate guanylyltransferase (GTP) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables mannose-1-phosphate guanylyltransferase (GTP) activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in GDP-mannose biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within L-ascorbic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cellulose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to ammonium ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to ozone IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Glucose-1-phosphate adenylyltransferase family protein
NP_001189713.1
  • CYTOKINESIS DEFECTIVE 1 (CYT1); CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT3G55590.1).
NP_181507.1
  • CYTOKINESIS DEFECTIVE 1 (CYT1); CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Nucleotidyl transferase (InterPro:IPR005835); BEST Arabidopsis thaliana protein match is: Glucose-1-phosphate adenylyltransferase family protein (TAIR:AT3G55590.1); Has 29262 Blast hits to 29252 proteins in 3030 species: Archae - 1046; Bacteria - 20499; Metazoa - 437; Fungi - 382; Plants - 510; Viruses - 0; Other Eukaryotes - 6388 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16588556..16591032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129535.4 → NP_181507.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22287, Q9C5B8
    UniProtKB/TrEMBL
    A0A178VW16, A0A5S9X5H6
    Conserved Domains (2) summary
    cd06425
    Location:1 → 234
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:256 → 335
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. NM_001202784.1 → NP_001189713.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22287, Q9C5B8
    UniProtKB/TrEMBL
    A0A178VW16, A0A5S9X5H6
    Conserved Domains (2) summary
    cd06425
    Location:1 → 234
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:256 → 335
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  3. NM_001336797.1 → NP_001325272.1  Glucose-1-phosphate adenylyltransferase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22287, Q9C5B8
    UniProtKB/TrEMBL
    A0A178VW16, A0A5S9X5H6
    Conserved Domains (2) summary
    cd06425
    Location:1 → 234
    M1P_guanylylT_B_like_N; N-terminal domain of the M1P-guanylyltransferase B-isoform like proteins
    cl00160
    Location:256 → 335
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22287.1

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