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Ssrp1 structure specific recognition protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81785, updated on 2-Nov-2024

Summary

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Official Symbol
Ssrp1provided by RGD
Official Full Name
structure specific recognition protein 1provided by RGD
Primary source
RGD:621143
See related
EnsemblRapid:ENSRNOG00000008825 AllianceGenome:RGD:621143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable histone binding activity and nucleosome binding activity. Predicted to be involved in nucleosome disassembly and regulation of chromatin organization. Predicted to be located in nucleus. Predicted to be part of FACT complex. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 375.5), Spleen (RPKM 361.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ssrp1 in Genome Data Viewer
Location:
3q24
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90531024..90541132)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (70124371..70134481)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72447516..72457621)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene proteoglycan 2, pro eosinophil major basic protein Neighboring gene proteoglycan 3, pro eosinophil major basic protein 2 Neighboring gene purinergic receptor P2X 3 Neighboring gene tankyrase 1 binding protein 1 Neighboring gene apelin receptor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. FACT Assists Base Excision Repair by Boosting the Remodeling Activity of RSC. Charles Richard JL, et al. PLoS Genet, 2016 Jul. PMID 27467129, Free PMC Article
  2. Rat and chick cDNA clones encoding HMG-like proteins. Wang L, et al. Nucleic Acids Res, 1993 Mar 25. PMID 8464746, Free PMC Article
  3. The histone chaperone FACT: structural insights and mechanisms for nucleosome reorganization. Winkler DD, et al. J Biol Chem, 2011 May 27. PMID 21454601, Free PMC Article
  4. Cooperative transcriptional activation by serum response factor and the high mobility group protein SSRP1. Spencer JA, et al. J Biol Chem, 1999 May 28. PMID 10336466
  5. Inhibition of transcription by platinum antitumor compounds. Todd RC, et al. Metallomics, 2009. PMID 20046924, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94298

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in nucleosome disassembly IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleosome disassembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of chromatin organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of chromatin organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of FACT complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of FACT complex IEA
Inferred from Electronic Annotation
more info
  
part_of FACT complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FACT complex subunit SSRP1
Names
T160
facilitates chromatin transcription complex subunit SSRP1
recombination signal sequence recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031121.1 → NP_112383.1  FACT complex subunit SSRP1

    See identical proteins and their annotated locations for NP_112383.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083588
    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A0A8L2R8I0, A6HMS9
    Conserved Domains (4) summary
    COG5165
    Location:21 → 480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    cd13231
    Location:332 → 427
    PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
    pfam00505
    Location:547 → 614
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:75 → 284
    SSrecog; Structure-specific recognition protein (SSRP1)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90531024..90541132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008761993.4 → XP_008760215.3  FACT complex subunit SSRP1 isoform X2

    UniProtKB/TrEMBL
    A0A8L2R8I0
    Conserved Domains (2) summary
    COG5165
    Location:114 → 573
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    pfam00505
    Location:640 → 707
    HMG_box; HMG (high mobility group) box

  2. XM_063284636.1 → XP_063140706.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9

  3. XM_063284634.1 → XP_063140704.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9
    Related
    ENSRNOP00000073084.3, ENSRNOT00000091901.3

  4. XM_006234477.4 → XP_006234539.2  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A0A8L2R8I0, A6HMS9
    Related
    ENSRNOP00000012022.4, ENSRNOT00000012022.6
    Conserved Domains (4) summary
    COG5165
    Location:21 → 480
    POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]
    cd13231
    Location:332 → 427
    PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2
    pfam00505
    Location:547 → 614
    HMG_box; HMG (high mobility group) box
    pfam03531
    Location:75 → 284
    SSrecog; Structure-specific recognition protein (SSRP1)

  5. XM_063284638.1 → XP_063140708.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9

  6. XM_063284635.1 → XP_063140705.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9

  7. XM_063284637.1 → XP_063140707.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9

  8. XM_063284633.1 → XP_063140703.1  FACT complex subunit SSRP1 isoform X1

    UniProtKB/Swiss-Prot
    Q04931, Q5XIT2
    UniProtKB/TrEMBL
    A6HMS9
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04931.2 GenPept UniProtKB/Swiss-Prot:Q04931

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