SOBIR1 Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SOBIR1
Gene description: Leucine-rich repeat protein kinase family protein
Primary source: Araport:AT2G31880
Locus tag: AT2G31880
See related: TAIR:AT2G31880
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: EVERSHED; EVR; F20M17.8; F20M17_8; SUPPRESSOR OF BIR1 1
Summary: Encodes a putative leucine rich repeat transmembrane protein that is expressed in response to Pseudomonas syringae. Expression of SRRLK may be required for silencing via lsiRNAs. Regulates cell death and innate immunity.
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Genomic context

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See SOBIR1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 1

Sequence:: Chromosome: 2; NC_003071.7 (13554870..13556977)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex.
Title: A pair of G-type lectin receptor-like kinases modulates nlp20-mediated immune responses by coupling to the RLP23 receptor complex.
Hypermorphic SERK1 Mutations Function via a SOBIR1 Pathway to Activate Floral Abscission Signaling.
Title: Hypermorphic SERK1 Mutations Function via a SOBIR1 Pathway to Activate Floral Abscission Signaling.
Study discovered SOBIR1/EVR as a regulator of secondary growth. SOBIR1/EVR acts through a mechanism that involves BREVIPEDICELLUS (BP) and ERECTA (ER). SOBIR1/EVR physically interacts with ER and that defects caused by the sobir1/evr mutation are aggravated by mutating ER, indicating that SOBIR1/EVR and ERECTA act together in the control of the precocious formation of xylem fiber development.
Title: SOBIR1/EVR prevents precocious initiation of fiber differentiation during wood development through a mechanism involving BP and ERECTA.
The 1.55 A resolution crystal structure of the immune receptor kinase SOBIR1 from Arabidopsis is presented. The ectodomain structure reveals the presence of five leucine-rich repeats sandwiched between noncanonical capping domains. The disulfide-bond-stabilized N-terminal cap harbours an unusual beta-hairpin structure.
Title: Crystal structure of the leucine-rich repeat ectodomain of the plant immune receptor kinase SOBIR1.
delineated the genetic interactions between SOBIR1, BAK1, and AGB1 in NHR to P. oryzae in Arabidopsis and found SOBIR1 and AGB1 independently control NHR to P. oryzae in Arabidopsis pen2-1 mutant plants
Title: SOBIR1 and AGB1 independently contribute to nonhost resistance to Pyricularia oryzae (syn. Magnaporthe oryzae) in Arabidopsis thaliana.
AvrPto suppresses Arabidopsis SOBIR1-induced cell death in N. benthamiana.
Title: The Bacterial Effector AvrPto Targets the Regulatory Coreceptor SOBIR1 and Suppresses Defense Signaling Mediated by the Receptor-Like Protein Cf-4.
BAK1 and SOBIR1 associate with each other in planta when the function of BIR1 is compromised.
Title: Loss-of-function of Arabidopsis receptor-like kinase BIR1 activates cell death and defense responses mediated by BAK1 and SOBIR1.
SOBIR1 is involved in both penetration and post-penetration resistance to M. oryzae in Arabidopsis.
Title: SOBIR1 contributes to non-host resistance to Magnaporthe oryzae in Arabidopsis.
mutation of suppressor of BIR1-1, which encodes an emerging positive regulator of transmembrane receptors in plants, suppressed the effects of BAK1 overexpression.
Title: An Overdose of the Arabidopsis Coreceptor BRASSINOSTEROID INSENSITIVE1-ASSOCIATED RECEPTOR KINASE1 or Its Ectodomain Causes Autoimmunity in a SUPPRESSOR OF BIR1-1-Dependent Manner.
AtSOBIR1 interacts with AtRLP23.
Title: Arabidopsis thaliana receptor-like protein AtRLP23 associates with the receptor-like kinase AtSOBIR1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_128746.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of floral organ abscission	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in peroxisome	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Leucine-rich repeat protein kinase family protein

NP_180747.1

SUPPRESSOR OF BIR1 1 (SOBIR1); FUNCTIONS IN: protein serine/threonine kinase activity, kinase activity, ATP binding; INVOLVED IN: protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway, positive regulation of defense response, negative regulation of floral organ abscission, positive regulation of cell death; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, catalytic domain (InterPro:IPR000719), Leucine-rich repeat (InterPro:IPR001611), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271); BEST Arabidopsis thaliana protein match is: Leucine-rich repeat protein kinase family protein (TAIR:AT5G63930.1); Has 176453 Blast hits to 132218 proteins in 4789 species: Archae - 165; Bacteria - 16198; Metazoa - 50399; Fungi - 11231; Plants - 77353; Viruses - 425; Other Eukaryotes - 20682 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

13554870..13556977

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_128746.3 → NP_180747.1 Leucine-rich repeat protein kinase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_180747.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93Z40, Q9SKB2

UniProtKB/TrEMBL

A0A178W2K5, A0A5S9X333

Conserved Domains (3) summary

PLN00113
Location:99 → 233

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00033
Location:113 → 136

LRR_RI; leucine-rich repeat [structural motif]

cl21453
Location:353 → 639

PKc_like; Protein Kinases, catalytic domain