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Pi4kb phosphatidylinositol 4-kinase beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 81747, updated on 2-Nov-2024

Summary

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Official Symbol
Pi4kbprovided by RGD
Official Full Name
phosphatidylinositol 4-kinase betaprovided by RGD
Primary source
RGD:621214
See related
EnsemblRapid:ENSRNOG00000021024 AllianceGenome:RGD:621214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pik4cb
Summary
Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in inner ear development; phosphatidylinositol phosphate biosynthetic process; and phosphatidylinositol-mediated signaling. Predicted to act upstream of or within lysosome organization. Predicted to be located in Golgi membrane. Predicted to be active in cytoplasm and membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness. Orthologous to human PI4KB (phosphatidylinositol 4-kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 175.8), Kidney (RPKM 157.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pi4kb in Genome Data Viewer
Location:
2q34
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (185229392..185261697)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (182540377..182572684)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (196139724..196172055)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene selenium binding protein 1 Neighboring gene regulatory factor X5 Neighboring gene uncharacterized LOC102547008 Neighboring gene zinc finger protein 687 Neighboring gene proteasome 26S subunit ubiquitin receptor, non-ATPase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s). Bojjireddy N, et al. Arch Biochem Biophys, 2013 Sep 15. PMID 23899475
  2. Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids. Einicker-Lamas M, et al. J Biochem, 2003 Oct. PMID 14607979
  3. Cloning and characterization of a 92 kDa soluble phosphatidylinositol 4-kinase. Nakagawa T, et al. Biochem J, 1996 Dec 1. PMID 8973579, Free PMC Article
  4. Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells. de Barry J, et al. J Biol Chem, 2006 Jun 30. PMID 16638749
  5. Overexpression of kidney phosphatidylinositol 4-kinasebeta and phospholipase C(gamma1) proteins in two rodent models of polycystic kidney disease. Cuozzo FP, et al. Biochim Biophys Acta, 2002 May 21. PMID 12009430

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results suggest that the anti-inflammatory effects of sanguinarine on PtdIns 3-kinase signaling pathway are more likely an indirect effect and emphasize the importance of the cross talk between type II PtdIns 4-kinases and PtdIns 3-kinases.
    Title: Sanguinarine suppresses IgE induced inflammatory responses through inhibition of type II PtdIns 4-kinase(s).
  2. Work suggests an important role for both eEF1A2 and PI4KIIIbeta in the control of PI(4,5)P(2) signaling and actin remodeling.
    Title: Eukaryotic elongation factor 1A2 cooperates with phosphatidylinositol-4 kinase III beta to stimulate production of filopodia through increased phosphatidylinositol-4,5 bisphosphate generation.
  3. NCS-1 protein and 1-phosphatidylinositol 4-kinase b interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
    Title: Neuronal calcium sensor 1 and phosphatidylinositol 4-OH kinase beta interact in neuronal cells and are translocated to membranes during nucleotide-evoked exocytosis.
  4. functional implication of a NCS-1.PI4K-beta complex in regulated exocytosis in neurons
    Title: Functional implication of neuronal calcium sensor-1 and phosphoinositol 4-kinase-beta interaction in regulated exocytosis of PC12 cells.
  5. Overexpression of a PI4K beta mutant in rat mast cells inhibits IgE receptor-triggered phosphatidylinositol 4,5-bisphosphate (PIP2) hydrolysis and exocytosis.
    Title: Neuronal calcium sensor-1 and phosphatidylinositol 4-kinase beta regulate IgE receptor-triggered exocytosis in cultured mast cells.
  6. there is a physical and functional relationship between eEF1A2 and PI4KIIIbeta
    Title: Binding of elongation factor eEF1A2 to phosphatidylinositol 4-kinase beta stimulates lipid kinase activity and phosphatidylinositol 4-phosphate generation.
  7. phosphatidylinositol-4 kinase in basolateral membranes from kidney cells is activated by sphingosine-1-phosphate
    Title: Sphingosine-1-phosphate formation activates phosphatidylinositol-4 kinase in basolateral membranes from kidney cells: crosstalk in cell signaling through sphingolipids and phospholipids.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 1-phosphatidylinositol 4-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol 4-kinase activity TAS
Traceable Author Statement
more info
 PubMed 
enables 14-3-3 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables 14-3-3 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables 14-3-3 protein binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in inner ear development IEA
Inferred from Electronic Annotation
more info
  
involved_in inner ear development ISO
Inferred from Sequence Orthology
more info
  
involved_in inner ear development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lysosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase beta
Names
PI4K-beta
PI4Kbeta
catalytic phosphatidylinositol 4-kinase beta
phosphatidylinositol 4-kinase, catalytic, beta polypeptide
ptdIns 4-kinase beta
NP_112345.1
XP_008759555.1
XP_038959158.1
XP_038959159.1
XP_038959160.1
XP_038959161.1
XP_038959162.1
XP_038959163.1
XP_063138702.1
XP_063138703.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031083.2 → NP_112345.1  phosphatidylinositol 4-kinase beta

    See identical proteins and their annotated locations for NP_112345.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    O08561
    UniProtKB/TrEMBL
    A0A8L2QJX4, A6K2T7
    Conserved Domains (2) summary
    cd05168
    Location:529 → 816
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:2 → 66
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    185229392..185261697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039103230.2 → XP_038959158.1  phosphatidylinositol 4-kinase beta isoform X1

    UniProtKB/TrEMBL
    A0A8L2QJX4
    Related
    ENSRNOP00000082231.2, ENSRNOT00000103639.2
    Conserved Domains (2) summary
    cd05168
    Location:554 → 862
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:27 → 91
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  2. XM_008761333.4 → XP_008759555.1  phosphatidylinositol 4-kinase beta isoform X4

    See identical proteins and their annotated locations for XP_008759555.1

    UniProtKB/TrEMBL
    A0A8I6ALD3, A0A8L2QJX4
    Related
    ENSRNOP00000093461.1, ENSRNOT00000112810.2
    Conserved Domains (1) summary
    cd05168
    Location:554 → 841
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta

  3. XM_039103233.2 → XP_038959161.1  phosphatidylinositol 4-kinase beta isoform X3

    UniProtKB/TrEMBL
    A0A0G2JYH1
    Conserved Domains (2) summary
    cd05168
    Location:539 → 847
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:27 → 91
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  4. XM_039103235.2 → XP_038959163.1  phosphatidylinositol 4-kinase beta isoform X6

    UniProtKB/TrEMBL
    A0A8I5ZT79, A0A8L2QJX4
    Related
    ENSRNOP00000095998.2, ENSRNOT00000112486.2
    Conserved Domains (2) summary
    cd05168
    Location:539 → 826
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:27 → 91
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  5. XM_039103231.2 → XP_038959159.1  phosphatidylinositol 4-kinase beta isoform X1

    UniProtKB/TrEMBL
    A0A8L2QJX4
    Conserved Domains (2) summary
    cd05168
    Location:554 → 862
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:27 → 91
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  6. XM_039103232.2 → XP_038959160.1  phosphatidylinositol 4-kinase beta isoform X2

    UniProtKB/TrEMBL
    A0A8L2QJX4
    Related
    ENSRNOP00000089657.2, ENSRNOT00000118319.2
    Conserved Domains (2) summary
    cd05168
    Location:542 → 850
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:15 → 79
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  7. XM_063282632.1 → XP_063138702.1  phosphatidylinositol 4-kinase beta isoform X7

    UniProtKB/TrEMBL
    A0A8I6ASK5

  8. XM_039103234.2 → XP_038959162.1  phosphatidylinositol 4-kinase beta isoform X5

    UniProtKB/TrEMBL
    A0A0G2JYH1, A0A8I6AD21
    Related
    ENSRNOP00000039342.3, ENSRNOT00000040501.4
    Conserved Domains (2) summary
    cd05168
    Location:529 → 837
    PI4Kc_III_beta; Catalytic domain of Type III Phosphoinositide 4-kinase beta
    cd22246
    Location:2 → 66
    PI4KB_NTD; N-terminal domain of phosphatidylinositol 4-kinase beta

  9. XM_063282633.1 → XP_063138703.1  phosphatidylinositol 4-kinase beta isoform X8

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08561.1 GenPept UniProtKB/Swiss-Prot:O08561

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