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Cdk16 cyclin-dependent kinase 16 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81741, updated on 14-Nov-2024

Summary

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Official Symbol
Cdk16provided by RGD
Official Full Name
cyclin-dependent kinase 16provided by RGD
Primary source
RGD:620584
See related
EnsemblRapid:ENSRNOG00000008578 AllianceGenome:RGD:620584
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pctk1
Summary
Enables protein serine/threonine kinase activity. Predicted to be involved in several processes, including positive regulation of autophagy; regulation of insulin secretion involved in cellular response to glucose stimulus; and secretion by cell. Located in synaptic vesicle. Is active in synaptic vesicle membrane. Orthologous to human CDK16 (cyclin dependent kinase 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 87.6), Heart (RPKM 84.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cdk16 in Genome Data Viewer
Location:
Xq11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (4046330..4057825, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1492814..1504309, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1707285..1718821, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene GTP binding protein 4, pseudogene 2 Neighboring gene ubiquitin specific peptidase 11 Neighboring gene ubiquitin-like modifier activating enzyme 1 Neighboring gene RNA binding motif protein 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of alternatively spliced PCTAIRE-1 mRNA in PC12 cells and neonatal rat brain. Gao CY, et al. Gene, 1996 Oct 17. PMID 8918260
  2. Analysis of substrate specificity and cyclin Y binding of PCTAIRE-1 kinase. Shehata SN, et al. Cell Signal, 2012 Nov. PMID 22796189, Free PMC Article
  3. Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology. Wu K, et al. Neurobiol Learn Mem, 2012 Jan. PMID 21982980, Free PMC Article
  4. Cyclin-dependent kinase 5-dependent phosphorylation of Pctaire1 regulates dendrite development. Fu WY, et al. Neuroscience, 2011 Apr 28. PMID 21335063
  5. Identification of tudor repeat associator with PCTAIRE 2 (Trap). A novel protein that interacts with the N-terminal domain of PCTAIRE 2 in rat brain. Hirose T, et al. Eur J Biochem, 2000 Apr. PMID 10727952

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Behavioral experiments suggested that overexpression of Pctk1 produces a deficit in learning and memory.
    Title: Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.
  2. Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein
    Title: Pctaire1 phosphorylates N-ethylmaleimide-sensitive fusion protein: implications in the regulation of its hexamerization and exocytosis.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in growth hormone secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in growth hormone secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in growth hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron projection development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of autophagy IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell cycle phase transition IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IEA
Inferred from Electronic Annotation
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclin-dependent kinase 16
Names
PCTAIRE protein kinase 1
PCTAIRE-1 protein kinase, alternatively spliced
PCTAIRE-motif protein kinase 1
cell division protein kinase 16
serine/threonine-protein kinase PCTAIRE-1
NP_001004132.1
NP_112339.2
XP_006256679.2
XP_063136393.1
XP_063136394.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004132.2 → NP_001004132.1  cyclin-dependent kinase 16

    See identical proteins and their annotated locations for NP_001004132.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    A0A9K3Y885, Q63686, Q63687
    UniProtKB/TrEMBL
    A0A140UHY2, A6JZT1, D4A7B3, F1LM49, Q68G39
    Conserved Domains (1) summary
    cd07873
    Location:162 → 458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

  2. NM_031077.2 → NP_112339.2  cyclin-dependent kinase 16

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000021
    UniProtKB/Swiss-Prot
    A0A9K3Y885, Q63686, Q63687
    UniProtKB/TrEMBL
    A0A140UHY2, A6JZT1, D4A7B3, F1LM49, Q68G39
    Conserved Domains (1) summary
    cd07873
    Location:162 → 458
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    4046330..4057825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063280324.1 → XP_063136394.1  cyclin-dependent kinase 16 isoform X2

  2. XM_006256617.5 → XP_006256679.2  cyclin-dependent kinase 16 isoform X3

    UniProtKB/TrEMBL
    A0A8J8YEJ1
    Related
    ENSRNOP00000011592.8, ENSRNOT00000011592.9
    Conserved Domains (1) summary
    cd07873
    Location:244 → 540
    STKc_PCTAIRE1; Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase

  3. XM_063280323.1 → XP_063136393.1  cyclin-dependent kinase 16 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63686.2 GenPept UniProtKB/Swiss-Prot:Q63686

Gene LinkOut

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