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FRA8 Exostosin family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817357, updated on 18-Sep-2024

Summary

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Official Symbol
FRA8
Official Full Name
Exostosin family protein
Primary source
TAIR:AT2G28110
Locus tag
AT2G28110
See related
Araport:AT2G28110
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F24D13.10; F24D13_10; FRAGILE FIBER 8; IRREGULAR XYLEM 7; IRX7
Summary
Homolog to AT5G22940, a member of glycosyltransferase family 47 that is involved in secondary cell wall biosynthesis. It exhibits high sequence similarity to tobacco (Nicotiana plumbaginifolia) pectin glucuronyltransferase. Protein has a domain that shares significant similarity with the pfam03016 domain. It is expressed specifically in developing vessels and fiber cells, and FRA8 is targeted to Golgi. Mutants have irregular xylem formation, reduced cellulose levels and plants are smaller than normal siblings.
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Genomic context

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See FRA8 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (11977865..11980003, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Heavy metal transport/detoxification superfamily protein Neighboring gene ncRNA Neighboring gene alpha-L-fucosidase 1 Neighboring gene replication factor-A carboxy-terminal domain protein Neighboring gene Major facilitator superfamily protein Neighboring gene actin protein 2/3 complex subunit-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Irregular xylem 7 (IRX7) is required for anchoring seed coat mucilage in Arabidopsis. Hu R, et al. Plant Mol Biol, 2016 Sep. PMID 27333892
  2. Arabidopsis fragile fiber8, which encodes a putative glucuronyltransferase, is essential for normal secondary wall synthesis. Zhong R, et al. Plant Cell, 2005 Dec. PMID 16272433, Free PMC Article
  3. The Arabidopsis irregular xylem8 mutant is deficient in glucuronoxylan and homogalacturonan, which are essential for secondary cell wall integrity. Persson S, et al. Plant Cell, 2007 Jan. PMID 17237350, Free PMC Article
  4. Comparison of five xylan synthesis mutants reveals new insight into the mechanisms of xylan synthesis. Brown DM, et al. Plant J, 2007 Dec. PMID 17944810
  5. Identification of novel genes in Arabidopsis involved in secondary cell wall formation using expression profiling and reverse genetics. Brown DM, et al. Plant Cell, 2005 Aug. PMID 15980264, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_179782.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables glucuronosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within glucuronoxylan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glucuronoxylan biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within plant-type secondary cell wall biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Exostosin family protein
NP_850113.2
  • FRAGILE FIBER 8 (FRA8); CONTAINS InterPro DOMAIN/s: Exostosin-like (InterPro:IPR004263); BEST Arabidopsis thaliana protein match is: FRA8 homolog (TAIR:AT5G22940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11977865..11980003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179782.4 → NP_850113.2  Exostosin family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850113.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8RXC5, Q9ZUV3
    UniProtKB/TrEMBL
    A0A5S9X221, W8Q712
    Conserved Domains (1) summary
    pfam03016
    Location:94 → 391
    Exostosin; Exostosin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ZUV3.1

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