Cdo1 cysteine dioxygenase type 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cdo1provided by RGD
Official Full Name: cysteine dioxygenase type 1provided by RGD
Primary source: RGD:69262
See related: EnsemblRapid:ENSRNOG00000000158 AllianceGenome:RGD:69262
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cysteine dioxygenase activity and ferrous iron binding activity. Involved in several processes, including L-cysteine catabolic process; lactation; and response to glucagon. Predicted to be located in cytosol. Biomarker of hypertension. Orthologous to human CDO1 (cysteine dioxygenase type 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 3802.8), Adrenal (RPKM 645.7) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18q11

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (41619076..41633719, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (39432473..39447253, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (40702027..40716901, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A pH-dependent kinetic study shows that both cross-linked and un-cross-linked CDO are active but the optimal pH decreases with the presence of the cross-link.
Title: The Cys-Tyr cross-link of cysteine dioxygenase changes the optimal pH of the reaction without a structural change.
redox switch commits CDO towards either formation of the Cys93-Tyr157 crosslink or oxidation of the cysteine substrate
Title: Shifting redox states of the iron center partitions CDO between crosslink formation or cysteine oxidation.
Data suggest that biocatalysis by cysteine dioxygenase (CDO1) involves formation of persulfides of both cysteine and 3-mercaptopropionic acid under reducing conditions; these persulfides are stabilized by iron in active site of CDO1.
Title: Mechanistic implications of persulfenate and persulfide binding in the active site of cysteine dioxygenase.
Correlating crosslink formation with enzymatic activity in cysteine dioxygenase.
Title: Correlating crosslink formation with enzymatic activity in cysteine dioxygenase.
Iron dissociation from the CDO active site exhibits an extremely slow dissociation rate constant, illustrating the stability of the resting state CDO; dioxygenase activity is directly proportional to the concentration of iron.
Title: A strongly bound high-spin iron(II) coordinates cysteine and homocysteine in cysteine dioxygenase.
1.4 A resolution crystal structure of the Fe(2+)-dependent enzyme cysteine dioxygenase (CDO) containing a putative intermediate trapped in its active site pocket
Title: A putative Fe2+-bound persulfenate intermediate in cysteine dioxygenase.
The regulation of Cysteine-Tyrosine cofactor formation in CDO by ambient cysteine levels represents an unusual form of substrate-mediated feed-forward activation of enzyme activity with important physiological consequences.
Title: Synthesis of amino acid cofactor in cysteine dioxygenase is regulated by substrate and represents a novel post-translational regulation of activity.
Mammary and hepatic cysteine dioxygenase and cysteine sulfinic acid decarboxylase in pregnant and nursing rats are reported.
Title: Enzymes of the taurine biosynthetic pathway are expressed in rat mammary gland.
In the living rat, inhibition of the proteasome with PS1 (proteasome inhibitor 1) dramatically stabilized CDO in the liver under dietary conditions that normally favour its degradation
Title: Regulation of cysteine dioxygenase degradation is mediated by intracellular cysteine levels and the ubiquitin-26 S proteasome system in the living rat.
Results describe the in vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system in the liver and kidney.
Title: In vivo regulation of cysteine dioxygenase via the ubiquitin-26S proteasome system.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

RH139615 (e-PCR)
- UniSTS:221699

RH127714 (e-PCR)
- UniSTS:211024

D18Wox19 (e-PCR)
- UniSTS:239974

D18Wox20 (e-PCR)
- UniSTS:239984

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine dioxygenase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables cysteine dioxygenase activity	ISO Inferred from Sequence Orthology more info
enables cysteine dioxygenase activity	TAS Traceable Author Statement more info	PubMed
enables ferrous iron binding	IBA Inferred from Biological aspect of Ancestor more info
enables ferrous iron binding	IDA Inferred from Direct Assay more info	PubMed
enables ferrous iron binding	ISO Inferred from Sequence Orthology more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables nickel cation binding	ISO Inferred from Sequence Orthology more info
enables nickel cation binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in L-cysteine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-cysteine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in L-cysteine metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in cysteine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in lactation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to amino acid	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cAMP	IDA Inferred from Direct Assay more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucagon	IDA Inferred from Direct Assay more info	PubMed
involved_in response to glucocorticoid	IDA Inferred from Direct Assay more info	PubMed
involved_in taurine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cysteine dioxygenase type 1

Names: CDO; CDO-I; cysteine dioxygenase 1, cytosolic; cysteine dioxygenase, type I; cytosolic cysteine dioxygenase 1

NP_434696.1

EC 1.13.11.20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_052809.2 → NP_434696.1 cysteine dioxygenase type 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000018

UniProtKB/Swiss-Prot

P21816, Q6NS32

UniProtKB/TrEMBL

A0A8I5ZKB1, A6IWW6

Related

ENSRNOP00000000172.4, ENSRNOT00000000172.7

Conserved Domains (1) summary

pfam05995
Location:2 → 170

CDO_I; Cysteine dioxygenase type I