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3BETAHSD/D2 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817166, updated on 18-Sep-2024

Summary

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Official Symbol
3BETAHSD/D2
Official Full Name
3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
Primary source
TAIR:AT2G26260
Locus tag
AT2G26260
See related
Araport:AT2G26260
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
3beta-hydroxysteroid- dehydrogenase/decarboxylase isoform 2; 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2; AT3BETAHSD/D; AT3BETAHSD/D2; T1D16.10; T1D16_10
Summary
Encodes an enzyme with 3beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity <i>in vitro</i>. The activity of the enzyme was determined using microsomal extracts of yeast overexpressing the <i>Arabidopsis</i> gene. Cytosolic fractions failed to be associated to the activity, leading to the speculation that the enzyme is membrane-bound.
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Genomic context

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See 3BETAHSD/D2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Sequence:
Chromosome: 2; NC_003071.7 (11178064..11183278)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uricase / urate oxidase / nodulin 35 Neighboring gene Transmembrane proteins 14C Neighboring gene 3-ketoacyl-CoA synthase 10 Neighboring gene BRCT domain DNA repair protein Neighboring gene CTC-interacting domain 7 Neighboring gene root-specific kinase 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation. Kriechbaumer V, et al. Sci Rep, 2018 Feb 2. PMID 29396477, Free PMC Article
  2. Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis. Kim B, et al. Mol Cells, 2012 Jul. PMID 22673766, Free PMC Article
  3. Molecular and enzymatic characterizations of novel bifunctional 3beta-hydroxysteroid dehydrogenases/C-4 decarboxylases from Arabidopsis thaliana. Rahier A, et al. J Biol Chem, 2006 Sep 15. PMID 16835224
  4. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RTN20 as well as RTN19 can be considered a specialised subclass of reticulons most likely not directly involved in ER tubulation and structure as shown for other reticulons, but in lipid regulation. [RTN19]
    Title: The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation.
  2. Arabidopsis 3betaHSD/D genes thus appears to affect auxin transporter activity, possibly by altering sterol composition in the membranes.
    Title: Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036345.1
NM_128183.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IEA
Inferred from Electronic Annotation
more info
  
enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in auxin transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
NP_001031422.1
  • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (3BETAHSD/D2); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (TAIR:AT1G47290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_180194.2
  • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (3BETAHSD/D2); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388), NAD(P)-binding domain (InterPro:IPR016040), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (TAIR:AT1G47290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11178064..11183278
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128183.4 → NP_180194.2  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180194.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O64845, Q67ZE1
    UniProtKB/TrEMBL
    A0A178VT10
    Conserved Domains (3) summary
    cd09813
    Location:11 → 358
    3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
    pfam01073
    Location:13 → 288
    3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
    pfam02453
    Location:384 → 539
    Reticulon; Reticulon

  2. NM_001036345.1 → NP_001031422.1  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031422.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VT10
    Conserved Domains (2) summary
    pfam02453
    Location:293 → 448
    Reticulon; Reticulon
    cl21454
    Location:1 → 267
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q67ZE1.2

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