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Camlg calcium modulating ligand [ Rattus norvegicus (Norway rat) ]

Gene ID: 81715, updated on 2-Nov-2024

Summary

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Official Symbol
Camlgprovided by RGD
Official Full Name
calcium modulating ligandprovided by RGD
Primary source
RGD:69297
See related
EnsemblRapid:ENSRNOG00000021911 AllianceGenome:RGD:69297
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Caml
Summary
Enables cell adhesion molecule binding activity. Involved in tail-anchored membrane protein insertion into ER membrane. Part of GET complex. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type II. Orthologous to human CAMLG (calcium modulating ligand). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Testes (RPKM 57.1), Brain (RPKM 56.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Camlg in Genome Data Viewer
Location:
17p14
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (8997868..9009140, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (8992697..9003576, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (9523792..9534683, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 5 open reading frame 24 Neighboring gene DEAD-box helicase 46 Neighboring gene transfer RNA serine (anticodon AGA) 29 Neighboring gene beta-1,4-galactosyltransferase 7 Neighboring gene transmembrane p24 trafficking protein 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cloning of rat calcium-modulating cyclophilin ligand. Lee SJ, et al. DNA Seq, 2001. PMID 11762198
  2. Expression and regulation of antimicrobial peptide rCRAMP after bacterial infection in primary rat meningeal cells. Brandenburg LO, et al. J Neuroimmunol, 2009 Dec 10. PMID 19879657
  3. TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain. Lan X, et al. Sci Rep, 2018 Jul 2. PMID 29967478, Free PMC Article
  4. IL-6 induction of hepatocyte proliferation through the Tmub1-regulated gene pathway. Liu M, et al. Int J Mol Med, 2012 Jun. PMID 22426572
  5. Molecular machinery for insertion of tail-anchored membrane proteins into the endoplasmic reticulum membrane in mammalian cells. Yamamoto Y, et al. Mol Cell, 2012 Nov 9. PMID 23041287

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CAML role in the hepatocyte proliferation.TMUB1 regulates hepatocyte proliferation by interacting with CAML and further interferes with the binding of CAML to cyclophilin B.
    Title: TMUB1 Inhibits BRL-3A Hepatocyte Proliferation by Interfering with the Binding of CAML to Cyclophilin B through its TM1 Hydrophobic Domain.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in B cell homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within receptor recycling ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of GET complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of GET complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of GET complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
guided entry of tail-anchored proteins factor CAMLG
Names
calcium signal-modulating cyclophilin ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001398726.1 → NP_001385655.1  guided entry of tail-anchored proteins factor CAMLG isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    F7FMD6, Q6DGG9, Q9ERK1
    Related
    ENSRNOP00000033945.7, ENSRNOT00000037088.7
    Conserved Domains (1) summary
    pfam14963
    Location:21 → 291
    CAML; Calcium signal-modulating cyclophilin ligand

  2. NM_053334.2 → NP_445786.2  guided entry of tail-anchored proteins factor CAMLG isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A8L2QHI2
    Conserved Domains (1) summary
    pfam14963
    Location:21 → 290
    CAML; Calcium signal-modulating cyclophilin ligand

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    8997868..9009140 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006253659.5 → XP_006253721.1  guided entry of tail-anchored proteins factor CAMLG isoform X1

    UniProtKB/TrEMBL
    A0A8I6AH13
    Related
    ENSRNOP00000092138.1, ENSRNOT00000103256.2
    Conserved Domains (1) summary
    pfam14963
    Location:21 → 269
    CAML; Calcium signal-modulating cyclophilin ligand

  2. XM_063276772.1 → XP_063132842.1  guided entry of tail-anchored proteins factor CAMLG isoform X2

    Related
    ENSRNOP00000108503.1, ENSRNOT00000136160.1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6DGG9.1 GenPept UniProtKB/Swiss-Prot:Q6DGG9

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