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CNGC6 cyclic nucleotide-gated channel 6 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816931, updated on 18-Sep-2024

Summary

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Official Symbol
CNGC6
Official Full Name
cyclic nucleotide-gated channel 6
Primary source
TAIR:AT2G23980
Locus tag
AT2G23980
See related
Araport:AT2G23980
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCNGC6; CYCLIC NUCLEOTIDE GATED CHANNEL 6; cyclic nucleotide-gated channel 6; T29E15.18; T29E15_18
Summary
Encodes a cyclic GMP-activated non-selective cation channel in the plasma membrane of guard cells.
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Genomic context

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See CNGC6 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (10201104..10205422, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene Class I glutamine amidotransferase-like superfamily protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene early nodulin-like protein 11 Neighboring gene serine carboxypeptidase-like 22

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity. Duong HN, et al. Plant J, 2022 Mar. PMID 34919778, Free PMC Article
  2. Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock. Niu WT, et al. J Exp Bot, 2020 Jan 1. PMID 31587070
  3. Cyclic nucleotide-gated ion channel 6 mediates thermotolerance in Arabidopsis seedlings by regulating nitric oxide production via cytosolic calcium ions. Peng X, et al. BMC Plant Biol, 2019 Aug 20. PMID 31429706, Free PMC Article
  4. A heat-activated calcium-permeable channel--Arabidopsis cyclic nucleotide-gated ion channel 6--is involved in heat shock responses. Gao F, et al. Plant J, 2012 Jun. PMID 22372427
  5. Calmodulin7: recent insights into emerging roles in plant development and stress. Basu R, et al. Plant Mol Biol, 2021 Sep. PMID 34398355

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.
    Title: Cyclic nucleotide-gated ion channel 6 is involved in extracellular ATP signaling and plant immunity.
  2. Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
    Title: Three CNGC Family Members, CNGC5, CNGC6, and CNGC9, Are Required for Constitutive Growth of Arabidopsis Root Hairs as Ca(2+)-Permeable Channels.
  3. Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock.
    Title: Arabidopsis cyclic nucleotide-gated channel 6 is negatively modulated by multiple calmodulin isoforms during heat shock.
  4. data indicate that CNGC6 acts upstream of nitric oxide in the heat shock pathway
    Title: Cyclic nucleotide-gated ion channel 6 mediates thermotolerance in Arabidopsis seedlings by regulating nitric oxide production via cytosolic calcium ions.
  5. The CNGC5 and CNGC6 genes encode unique cyclic GMP-activated nonselective Ca(2+)-permeable cation channels in the plasma membrane of Arabidopsis guard cells.
    Title: Identification of cyclic GMP-activated nonselective Ca2+-permeable cation channels and associated CNGC5 and CNGC6 genes in Arabidopsis guard cells.
  6. CNGC6 is a heat- and cAMP-activated PM Ca2+-permeable channel that is involved in heat shock responses.
    Title: A heat-activated calcium-permeable channel--Arabidopsis cyclic nucleotide-gated ion channel 6--is involved in heat shock responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001335878.1
NM_001335879.1
NM_001335880.1
NM_001335881.1
NM_001335882.1
NM_001335883.1
NM_001335884.1
NM_001335885.1
NM_001335886.1
NM_127960.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding TAS
Traceable Author Statement
more info
 PubMed 
enables intracellularly cGMP-activated cation channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in response to heat IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in root hair IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclic nucleotide-gated channel 6
NP_001318278.1
  • cyclic nucleotide-gated channel 6 (CNGC6); FUNCTIONS IN: calmodulin binding; INVOLVED IN: response to cadmium ion; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Potassium channel, voltage-dependent, EAG/ELK/ERG (InterPro:IPR003938), Ion transport (InterPro:IPR005821), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), IQ calmodulin-binding region (InterPro:IPR000048); BEST Arabidopsis thaliana protein match is: cyclic nucleotide gated channel 9 (TAIR:AT4G30560.1); Has 3569 Blast hits to 3382 proteins in 249 species: Archae - 0; Bacteria - 42; Metazoa - 1579; Fungi - 32; Plants - 1028; Viruses - 0; Other Eukaryotes - 888 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    10201104..10205422 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001335878.1 → NP_001318278.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82226, Q9XFS4
    UniProtKB/TrEMBL
    A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
    Conserved Domains (2) summary
    PLN03192
    Location:161 → 566
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:514 → 645
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  2. NM_001335884.1 → NP_001323886.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

  3. NM_001335881.1 → NP_001323885.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82226, Q9XFS4
    UniProtKB/TrEMBL
    A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
    Conserved Domains (2) summary
    PLN03192
    Location:161 → 566
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:514 → 645
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  4. NM_001335879.1 → NP_001323882.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

  5. NM_001335886.1 → NP_001323883.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82226, Q9XFS4
    UniProtKB/TrEMBL
    A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
    Conserved Domains (2) summary
    PLN03192
    Location:161 → 566
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:514 → 645
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  6. NM_001335885.1 → NP_001323884.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

  7. NM_001335882.1 → NP_001323879.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82226, Q9XFS4
    UniProtKB/TrEMBL
    A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
    Conserved Domains (2) summary
    PLN03192
    Location:161 → 566
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:514 → 645
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  8. NM_001335880.1 → NP_001323881.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VQ35, A0A1P8AYC4, A0A5S9X0Y2, A0A7G2EAK2

  9. NM_127960.3 → NP_565560.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565560.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82226, Q9XFS4
    UniProtKB/TrEMBL
    A0A178VQ35, A0A5S9X0Y2, A0A654EWQ3, A0A7G2EAK2
    Conserved Domains (2) summary
    PLN03192
    Location:161 → 566
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:514 → 645
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

  10. NM_001335883.1 → NP_001323880.1  cyclic nucleotide-gated channel 6 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VQ35, A0A1P8AYI8, A0A5S9X0Y2, A0A7G2EAK2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O82226.2

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