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RNR1 ribonucleotide reductase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816715, updated on 18-Sep-2024

Summary

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Official Symbol
RNR1
Official Full Name
ribonucleotide reductase 1
Primary source
TAIR:AT2G21790
Locus tag
AT2G21790
See related
Araport:AT2G21790
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATRNR1; CLS8; CRINKLY LEAVES 8; defective in pollen organelle DNA degradation 2; DPD2; R1; ribonucleotide reductase 1; RIBONUCLEOTIDE REDUCTASE 1; RIBONUCLEOTIDE REDUCTASE LARGE SUBUNIT 1
Summary
encodes large subunit of ribonucleotide reductase involved in the production of deoxyribonucleoside triphosphates (dNTPs) for DNA replication and repair
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Genomic context

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See RNR1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
17
Sequence:
Chromosome: 2; NC_003071.7 (9293261..9297861)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene cellulose synthase A9 Neighboring gene uncharacterized protein Neighboring gene essential meiotic endonuclease 1A Neighboring gene Cysteine/Histidine-rich C1 domain family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation. Germain A, et al. Plant J, 2012 Dec. PMID 23061883
  2. crinkled leaves 8--a mutation in the large subunit of ribonucleotide reductase--leads to defects in leaf development and chloroplast division in Arabidopsis thaliana. Garton S, et al. Plant J, 2007 Apr. PMID 17346262
  3. Mutations defective in ribonucleotide reductase activity interfere with pollen plastid DNA degradation mediated by DPD1 exonuclease. Tang LY, et al. Plant J, 2012 May. PMID 22239102
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The cooperative activity of two 3'-->5' exoribonucleases in chloroplast mRNA 3' end maturation, and support the hypothesis that RNR1 plays a significant role in the destabilization of mRNAs unprotected by ribosomes.
    Title: Ribonuclease II preserves chloroplast RNA homeostasis by increasing mRNA decay rates, and cooperates with polynucleotide phosphorylase in 3' end maturation.
  2. Data show that the defects in ribonucleotide reductase DPD2 (At2g21790) indirectly compromise the activity of DPD1 nuclease (At5g26940) in plastids, suggesting a different regulation of organellar DNA degradation in pollen.
    Title: Mutations defective in ribonucleotide reductase activity interfere with pollen plastid DNA degradation mediated by DPD1 exonuclease.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_127748.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA replication IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within deoxyribonucleoside triphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
ribonucleotide reductase 1
NP_179770.1
  • ribonucleotide reductase 1 (RNR1); FUNCTIONS IN: ribonucleoside-diphosphate reductase activity, ATP binding; INVOLVED IN: response to cadmium ion, DNA replication, deoxyribonucleoside triphosphate biosynthetic process; LOCATED IN: ribonucleoside-diphosphate reductase complex; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ribonucleotide reductase large subunit, N-terminal (InterPro:IPR013509), Ribonucleoside-diphosphate reductase, alpha subunit (InterPro:IPR013346), ATP-cone (InterPro:IPR005144), Ribonucleotide reductase large subunit, C-terminal (InterPro:IPR000788), Ribonucleotide reductase R1 subunit, N-terminal (InterPro:IPR008926); Has 15326 Blast hits to 14804 proteins in 2790 species: Archae - 206; Bacteria - 6388; Metazoa - 177; Fungi - 215; Plants - 88; Viruses - 606; Other Eukaryotes - 7646 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9293261..9297861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127748.4 → NP_179770.1  ribonucleotide reductase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179770.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O82573, Q9SJ20
    UniProtKB/TrEMBL
    A0A178VR42, A0A5S9X060, A0A654EUW8
    Conserved Domains (1) summary
    PLN02437
    Location:1 → 816
    PLN02437; ribonucleoside--diphosphate reductase large subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SJ20.1

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