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NIPA2 NIPA magnesium transporter 2 [ Homo sapiens (human) ]

Gene ID: 81614, updated on 5-Mar-2024

Summary

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Official Symbol
NIPA2provided by HGNC
Official Full Name
NIPA magnesium transporter 2provided by HGNC
Primary source
HGNC:HGNC:17044
See related
Ensembl:ENSG00000140157 MIM:608146; AllianceGenome:HGNC:17044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLC57A2
Summary
This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in colon (RPKM 14.5), appendix (RPKM 13.2) and 25 other tissues See more
Orthologs
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Genomic context

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See NIPA2 in Genome Data Viewer
Location:
15q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (22838666..22868384)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (20510413..20540236)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (23004684..23034402, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC283683 Neighboring gene Sharpr-MPRA regulatory region 3977 Neighboring gene golgin subfamily A member 6-like protein 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:23086519-23086752 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6259 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6260 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9154 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:23080143-23080643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9155 Neighboring gene NIPA magnesium transporter 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:23045427-23046179 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9158 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22999149-22999824 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr15:22990202-22991401 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22981163-22981662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22980661-22981162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9159 Neighboring gene cytoplasmic FMR1 interacting protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22925256-22925940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22905531-22906030 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22896003-22896502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22895501-22896002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22893404-22894371 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:22892435-22893403 Neighboring gene tubulin gamma complex component 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22859095-22860005 Neighboring gene NANOG hESC enhancer GRCh37_chr15:22803142-22803643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:22798435-22798945 Neighboring gene engulfment and cell motility 2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis. Zhao W, et al. Biochem Biophys Res Commun, 2019 Jun 11. PMID 31003774
  2. Functional study of NIPA2 mutations identified from the patients with childhood absence epilepsy. Xie H, et al. PLoS One, 2014. PMID 25347071, Free PMC Article
  3. NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy. Jiang Y, et al. Hum Genet, 2012 Jul. PMID 22367439
  4. Molecular identification of ancient and modern mammalian magnesium transporters. Quamme GA. Am J Physiol Cell Physiol, 2010 Mar. PMID 19940067
  5. Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances. Doornbos M, et al. Eur J Med Genet, 2009 Mar-Jun. PMID 19328872

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AGEs dose-dependently down-regulated the expression of NIPA2 in osteoblasts. NIPA2 also regulated osteoblast apoptosis by affecting the intracellular magnesium level and further affecting the osteogenic capacity of osteoblasts.
    Title: NIPA2 regulates osteoblast function via its effect on apoptosis pathways in type 2 diabetes osteoporosis.
  2. This study primarily reveals that a selective magnesium transporter NIPA2 may play a role in the pathogenesis of CAE.
    Title: Functional study of NIPA2 mutations identified from the patients with childhood absence epilepsy.
  3. mutations in NIPA2 gene were associated with childhood absence epilepsy (CAE), which indicated that the haploinsufficiency of NIPA2 might be a candidate mechanism underlying the IGE/CAE phenotypes caused by 15q11.2 microdeletions or rare mutations in NIPA2
    Title: NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy.
  4. located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes
    Title: Identification of four highly conserved genes between breakpoint hotspots BP1 and BP2 of the Prader-Willi/Angelman syndromes deletion region that have undergone evolutionary transposition mediated by flanking duplicons.
  5. quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales
    Title: Expression of 4 genes between chromosome 15 breakpoints 1 and 2 and behavioral outcomes in Prader-Willi syndrome.
  6. Altered mRNA expression is associated with prostate cancer recurrence.
    Title: Gene expression profiling predicts clinical outcome of prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2012-04-04)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2012-04-04)

ClinGen Genome Curation Page

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC5466

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables magnesium ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in magnesium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in magnesium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in magnesium ion transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
magnesium transporter NIPA2
Names
non imprinted in Prader-Willi/Angelman syndrome 2
non-imprinted in Prader-Willi/Angelman syndrome region protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021303.1 RefSeqGene

    Range
    5026..34744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001008860.3 → NP_001008860.1  magnesium transporter NIPA2 isoform a

    See identical proteins and their annotated locations for NP_001008860.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC011767, BK001120, DA082125, R56244
    Consensus CDS
    CCDS73693.1
    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Related
    ENSP00000501489.1, ENST00000674477.1
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  2. NM_001008892.3 → NP_001008892.1  magnesium transporter NIPA2 isoform a

    See identical proteins and their annotated locations for NP_001008892.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC011767, BC011775, DA082125, R56244, U90904
    Consensus CDS
    CCDS73693.1
    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Related
    ENSP00000381095.3, ENST00000398013.7
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  3. NM_001008894.3 → NP_001008894.1  magnesium transporter NIPA2 isoform b

    See identical proteins and their annotated locations for NP_001008894.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AC011767, AK300843, DA082125, R56244, U90904
    Consensus CDS
    CCDS73694.1
    UniProtKB/Swiss-Prot
    Q8N8Q9
    Related
    ENSP00000437746.2, ENST00000539711.2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  4. NM_001184888.2 → NP_001171817.1  magnesium transporter NIPA2 isoform b

    See identical proteins and their annotated locations for NP_001171817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a. Both variants 4 and 6 encode the same isoform (b).
    Source sequence(s)
    AC011767, AK313584, R56244, U90904
    Consensus CDS
    CCDS73694.1
    UniProtKB/Swiss-Prot
    Q8N8Q9
    Related
    ENSP00000352762.4, ENST00000359727.8
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  5. NM_001184889.2 → NP_001171818.1  magnesium transporter NIPA2 isoform a

    See identical proteins and their annotated locations for NP_001171818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC011767, AY732242, DA082125, R56244, U90904
    Consensus CDS
    CCDS73693.1
    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  6. NM_030922.7 → NP_112184.4  magnesium transporter NIPA2 isoform a

    See identical proteins and their annotated locations for NP_112184.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1, 2, 3 and 4 encode the same isoform (a).
    Source sequence(s)
    AC011767, BC000957, BM544162, DA082125, R56244, U90904
    Consensus CDS
    CCDS73693.1
    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Related
    ENSP00000337618.3, ENST00000337451.8
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    22838666..22868384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022651.3 → XP_016878140.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  2. XM_017022645.2 → XP_016878134.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  3. XM_047433150.1 → XP_047289106.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  4. XM_047433152.1 → XP_047289108.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  5. XM_011543877.3 → XP_011542179.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_011542179.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  6. XM_047433158.1 → XP_047289114.1  magnesium transporter NIPA2 isoform X2

  7. XM_017022649.3 → XP_016878138.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  8. XM_047433162.1 → XP_047289118.1  magnesium transporter NIPA2 isoform X2

  9. XM_011543878.4 → XP_011542180.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_011542180.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  10. XM_005272546.4 → XP_005272603.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272603.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  11. XM_006720367.2 → XP_006720430.1  magnesium transporter NIPA2 isoform X2

    See identical proteins and their annotated locations for XP_006720430.1

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  12. XM_011543880.4 → XP_011542182.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_011542182.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  13. XM_017022660.2 → XP_016878149.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  14. XM_005272550.4 → XP_005272607.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272607.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  15. XM_005272552.5 → XP_005272609.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272609.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Related
    ENSP00000501373.1, ENST00000674330.1
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  16. XM_017022662.2 → XP_016878151.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  17. XM_017022648.2 → XP_016878137.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  18. XM_047433155.1 → XP_047289111.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  19. XM_017022647.2 → XP_016878136.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  20. XM_047433160.1 → XP_047289116.1  magnesium transporter NIPA2 isoform X2

  21. XM_017022652.3 → XP_016878141.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  22. XM_047433151.1 → XP_047289107.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  23. XM_005272547.5 → XP_005272604.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272604.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  24. XM_017022656.2 → XP_016878145.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  25. XM_047433153.1 → XP_047289109.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  26. XM_047433163.1 → XP_047289119.1  magnesium transporter NIPA2 isoform X2

  27. XM_005272553.6 → XP_005272610.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272610.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  28. XM_017022663.2 → XP_016878152.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  29. XM_047433154.1 → XP_047289110.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  30. XM_047433156.1 → XP_047289112.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  31. XM_017022646.2 → XP_016878135.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  32. XM_047433159.1 → XP_047289115.1  magnesium transporter NIPA2 isoform X2

  33. XM_017022653.3 → XP_016878142.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  34. XM_006720364.3 → XP_006720427.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_006720427.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  35. XM_017022657.2 → XP_016878146.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  36. XM_011543879.4 → XP_011542181.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_011542181.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  37. XM_017022659.2 → XP_016878148.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  38. XM_017022650.3 → XP_016878139.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  39. XM_017022655.2 → XP_016878144.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Related
    ENSP00000381096.3, ENST00000398014.7
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  40. XM_017022661.2 → XP_016878150.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  41. XM_017022654.3 → XP_016878143.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  42. XM_005272548.4 → XP_005272605.1  magnesium transporter NIPA2 isoform X1

    See identical proteins and their annotated locations for XP_005272605.1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2
    Related
    ENSP00000501408.1, ENST00000674173.1
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 302
    Mg_trans_NIPA; Magnesium transporter NIPA

  43. XM_017022658.2 → XP_016878147.1  magnesium transporter NIPA2 isoform X2

    UniProtKB/Swiss-Prot
    Q8N8Q9
    Conserved Domains (1) summary
    pfam05653
    Location:8 → 283
    Mg_trans_NIPA; Magnesium transporter NIPA

  44. XM_047433157.1 → XP_047289113.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  45. XM_047433161.1 → XP_047289117.1  magnesium transporter NIPA2 isoform X2

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_021160017.1 Reference GRCh38.p14 PATCHES

    Range
    3732709..3762464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332624.1 → XP_054188599.1  magnesium transporter NIPA2 isoform X2

  2. XM_054332597.1 → XP_054188572.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  3. XM_054332589.1 → XP_054188564.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  4. XM_054332583.1 → XP_054188558.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  5. XM_054332603.1 → XP_054188578.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  6. XM_054332609.1 → XP_054188584.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  7. XM_054332619.1 → XP_054188594.1  magnesium transporter NIPA2 isoform X2

  8. XM_054332612.1 → XP_054188587.1  magnesium transporter NIPA2 isoform X2

  9. XM_054332620.1 → XP_054188595.1  magnesium transporter NIPA2 isoform X2

  10. XM_054332617.1 → XP_054188592.1  magnesium transporter NIPA2 isoform X2

  11. XM_054332614.1 → XP_054188589.1  magnesium transporter NIPA2 isoform X2

  12. XM_054332623.1 → XP_054188598.1  magnesium transporter NIPA2 isoform X2

  13. XM_054332586.1 → XP_054188561.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  14. XM_054332585.1 → XP_054188560.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  15. XM_054332596.1 → XP_054188571.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  16. XM_054332595.1 → XP_054188570.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  17. XM_054332608.1 → XP_054188583.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  18. XM_054332592.1 → XP_054188567.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  19. XM_054332591.1 → XP_054188566.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  20. XM_054332607.1 → XP_054188582.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  21. XM_054332602.1 → XP_054188577.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  22. XM_054332601.1 → XP_054188576.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  23. XM_054332584.1 → XP_054188559.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  24. XM_054332590.1 → XP_054188565.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  25. XM_054332600.1 → XP_054188575.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  26. XM_054332604.1 → XP_054188579.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  27. XM_054332594.1 → XP_054188569.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  28. XM_054332611.1 → XP_054188586.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  29. XM_054332606.1 → XP_054188581.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  30. XM_054332605.1 → XP_054188580.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  31. XM_054332588.1 → XP_054188563.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  32. XM_054332616.1 → XP_054188591.1  magnesium transporter NIPA2 isoform X2

  33. XM_054332587.1 → XP_054188562.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  34. XM_054332615.1 → XP_054188590.1  magnesium transporter NIPA2 isoform X2

  35. XM_054332598.1 → XP_054188573.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  36. XM_054332599.1 → XP_054188574.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  37. XM_054332621.1 → XP_054188596.1  magnesium transporter NIPA2 isoform X2

  38. XM_054332613.1 → XP_054188588.1  magnesium transporter NIPA2 isoform X2

  39. XM_054332622.1 → XP_054188597.1  magnesium transporter NIPA2 isoform X2

  40. XM_054332610.1 → XP_054188585.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  41. XM_054332593.1 → XP_054188568.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  42. XM_054332618.1 → XP_054188593.1  magnesium transporter NIPA2 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    20510413..20540236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378962.1 → XP_054234937.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  2. XM_054378940.1 → XP_054234915.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  3. XM_054378950.1 → XP_054234925.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  4. XM_054378978.1 → XP_054234953.1  magnesium transporter NIPA2 isoform X2

  5. XM_054378942.1 → XP_054234917.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  6. XM_054378943.1 → XP_054234918.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  7. XM_054378959.1 → XP_054234934.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  8. XM_054378939.1 → XP_054234914.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  9. XM_054378951.1 → XP_054234926.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  10. XM_054378964.1 → XP_054234939.1  magnesium transporter NIPA2 isoform X2

  11. XM_054378958.1 → XP_054234933.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  12. XM_054378967.1 → XP_054234942.1  magnesium transporter NIPA2 isoform X2

  13. XM_054378972.1 → XP_054234947.1  magnesium transporter NIPA2 isoform X2

  14. XM_054378973.1 → XP_054234948.1  magnesium transporter NIPA2 isoform X2

  15. XM_054378970.1 → XP_054234945.1  magnesium transporter NIPA2 isoform X2

  16. XM_054378977.1 → XP_054234952.1  magnesium transporter NIPA2 isoform X2

  17. XM_054378969.1 → XP_054234944.1  magnesium transporter NIPA2 isoform X2

  18. XM_054378966.1 → XP_054234941.1  magnesium transporter NIPA2 isoform X2

  19. XM_054378976.1 → XP_054234951.1  magnesium transporter NIPA2 isoform X2

  20. XM_054378954.1 → XP_054234929.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  21. XM_054378953.1 → XP_054234928.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  22. XM_054378941.1 → XP_054234916.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  23. XM_054378947.1 → XP_054234922.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  24. XM_054378961.1 → XP_054234936.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  25. XM_054378946.1 → XP_054234921.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  26. XM_054378945.1 → XP_054234920.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  27. XM_054378960.1 → XP_054234935.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  28. XM_054378952.1 → XP_054234927.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  29. XM_054378955.1 → XP_054234930.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  30. XM_054378949.1 → XP_054234924.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  31. XM_054378957.1 → XP_054234932.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  32. XM_054378937.1 → XP_054234912.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  33. XM_054378944.1 → XP_054234919.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  34. XM_054378968.1 → XP_054234943.1  magnesium transporter NIPA2 isoform X2

  35. XM_054378956.1 → XP_054234931.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  36. XM_054378936.1 → XP_054234911.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  37. XM_054378963.1 → XP_054234938.1  magnesium transporter NIPA2 isoform X2

  38. XM_054378935.1 → XP_054234910.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  39. XM_054378974.1 → XP_054234949.1  magnesium transporter NIPA2 isoform X2

  40. XM_054378948.1 → XP_054234923.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  41. XM_054378965.1 → XP_054234940.1  magnesium transporter NIPA2 isoform X2

  42. XM_054378975.1 → XP_054234950.1  magnesium transporter NIPA2 isoform X2

  43. XM_054378938.1 → XP_054234913.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  44. XM_054378934.1 → XP_054234909.1  magnesium transporter NIPA2 isoform X1

    UniProtKB/Swiss-Prot
    F8W7Y8, Q8N8Q9, Q96F03, Q9BVS2

  45. XM_054378971.1 → XP_054234946.1  magnesium transporter NIPA2 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N8Q9.1 GenPept UniProtKB/Swiss-Prot:Q8N8Q9

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