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cldnj claudin j [ Danio rerio (zebrafish) ]

Gene ID: 81589, updated on 2-Nov-2024

Summary

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Official Symbol
cldnjprovided by ZNC
Official Full Name
claudin jprovided by ZNC
Primary source
ZFIN:ZDB-GENE-010328-10
See related
Ensembl:ENSDARG00000058880 AllianceGenome:ZFIN:ZDB-GENE-010328-10
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cldn8l; fc30g01; wu:fc30g01
Summary
Predicted to enable structural molecule activity. Acts upstream of or within lifelong otolith mineralization. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in central nervous system; otic epithelium; otic vesicle; and ovary. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 116. Orthologous to human CLDN6 (claudin 6) and CLDN9 (claudin 9). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See cldnj in Genome Data Viewer
Location:
chromosome: 15
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (2631211..2632891, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (2666745..2669319, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene SH2B adaptor protein 2 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 30b Neighboring gene claudin e Neighboring gene claudin f

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The zebrafish gene claudinj is essential for normal ear function and important for the formation of the otoliths. Hardison AL, et al. Mech Dev, 2005 Jul. PMID 15925497
  2. Claudin7b is required for the formation and function of inner ear in zebrafish. Li X, et al. J Cell Physiol, 2018 Apr. PMID 28834538
  3. Wasl is crucial to maintain microglial core activities during glioblastoma initiation stages. Mazzolini J, et al. Glia, 2022 Jun. PMID 35194846, Free PMC Article
  4. Grhl2 deficiency impairs otic development and hearing ability in a zebrafish model of the progressive dominant hearing loss DFNA28. Han Y, et al. Hum Mol Genet, 2011 Aug 15. PMID 21610158
  5. The role of cldnh during the early retinal development in zebrafish. Lu J, et al. Exp Eye Res, 2020 Nov. PMID 32866532

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The role of cldnh during the early retinal development in zebrafish.
    Title: The role of cldnh during the early retinal development in zebrafish.
  2. Morpholino inhibition of claudinj expression showed similar defects in otolith formation.
    Title: The zebrafish gene claudinj is essential for normal ear function and important for the formation of the otoliths.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lifelong otolith mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
claudin j

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131769.2 → NP_571844.2  claudin j

    Status: VALIDATED

    Source sequence(s)
    CR382327
    UniProtKB/TrEMBL
    A0A8N7UZN0, Q90XR4
    Related
    ENSDARP00000076279.1, ENSDART00000081840.3
    Conserved Domains (1) summary
    cl21598
    Location:1 → 178
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    2631211..2632891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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