U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OR2T7 olfactory receptor family 2 subfamily T member 7 (gene/pseudogene) [ Homo sapiens (human) ]

Gene ID: 81458, updated on 25-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
OR2T7provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily T member 7 (gene/pseudogene)provided by HGNC
Primary source
HGNC:HGNC:15019
See related
Ensembl:ENSG00000227152 AllianceGenome:HGNC:15019
Gene type
protein coding
RefSeq status
INFERRED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR2T7P; OST723
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See OR2T7 in Genome Data Viewer
Location:
1q44
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248436359..248444316)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247880982..247888943)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248599660..248607617)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily T member 6 Neighboring gene MPRA-validated peak838 silencer Neighboring gene olfactory receptor family 2 subfamily T member 1 Neighboring gene MPRA-validated peak839 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr1:248616387-248616588 Neighboring gene olfactory receptor family 2 subfamily T member 2 Neighboring gene uncharacterized LOC105373279 Neighboring gene olfactory receptor family 2 subfamily T member 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
  2. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  3. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  4. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
olfactory receptor 2T7
Names
olfactory receptor OR1-44
olfactory receptor, family 2, subfamily T, member 7 pseudogene

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001386051.2 → NP_001372980.2  olfactory receptor 2T7 isoform 1

    Status: INFERRED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele encoded by the T2T-CHM13v2.0 genome assembly.
    Source sequence(s)
    CP068277
    UniProtKB/TrEMBL
    A0AAG2UVJ4
    Conserved Domains (1) summary
    cd15421
    Location:26 → 301
    7tmA_OR2T-like; olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_172522.1 RNA Sequence

    Status: INFERRED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1, coding, but represents the allele encoded by the GRCh38 reference assembly. This variant is represented as non-coding because a frameshift in the N-terminus results in a premature stop codon.
    Source sequence(s)
    AC138089
    Related
    ENST00000641557.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248436359..248444316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791755.1 Reference GRCh38.p14 PATCHES

    Range
    84333..92290
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187518.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    90399..98356
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_2

Genomic

  1. NT_187646.1 Reference GRCh38.p14 ALT_REF_LOCI_2

    Range
    86777..94734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247880982..247888943
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_004272.4: Suppressed sequence

    Description
    NG_004272.4: This RefSeq was removed because it is now thought that this locus is a transcribed gene.

  2. NM_001355223.1: Suppressed sequence

    Description
    NM_001355223.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.

  3. NM_001386052.1: Suppressed sequence

    Description
    NM_001386052.1: This RefSeq was removed because it is now thought that this gene is a pseudogene on the reference assembly GRCh38.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C7T2.1 GenPept UniProtKB/Swiss-Prot:P0C7T2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials