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CAMK4 calcium/calmodulin dependent protein kinase IV [ Homo sapiens (human) ]

Gene ID: 814, updated on 7-Apr-2024

Summary

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Official Symbol
CAMK4provided by HGNC
Official Full Name
calcium/calmodulin dependent protein kinase IVprovided by HGNC
Primary source
HGNC:HGNC:1464
See related
Ensembl:ENSG00000152495 MIM:114080; AllianceGenome:HGNC:1464
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
caMK; CaMKIV; CaMK IV; CaMK-GR
Summary
The product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 7.0), lymph node (RPKM 3.7) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See CAMK4 in Genome Data Viewer
Location:
5q22.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (111223583..111494886)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (111734219..112005186)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (110559281..110830584)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene proline rich nuclear receptor coactivator 2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16229 Neighboring gene RPS3A pseudogene 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16230 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16231 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22896 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:110644539-110645132 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:110783389-110783979 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:110838395-110838556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16233 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22900 Neighboring gene uncharacterized LOC105369177 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22901 Neighboring gene STARD4 antisense RNA 1 Neighboring gene StAR related lipid transfer domain containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway. Chang S, et al. Am J Reprod Immunol, 2020 Dec. PMID 32738170
  2. Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis. Du B, et al. Int Immunopharmacol, 2020 Mar. PMID 31978801
  3. MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4). Li Z, et al. Cell Death Dis, 2019 Oct 17. PMID 31624237, Free PMC Article
  4. Evidence of vanillin binding to CAMKIV explains the anti-cancer mechanism in human hepatic carcinoma and neuroblastoma cells. Naz H, et al. Mol Cell Biochem, 2018 Jan. PMID 28744811
  5. Calcium/calmodulin-dependent protein kinase IV gene polymorphisms in Korean alcohol-dependent patients. Jung WY, et al. Prog Neuropsychopharmacol Biol Psychiatry, 2017 Oct 3. PMID 28734942

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
    Title: CaMK4 controls follicular helper T cell expansion and function during normal and autoimmune T-dependent B cell responses.
  2. CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
    Title: CaMK4 overexpression in polycystic kidney disease promotes mTOR-mediated cell proliferation.
  3. Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
    Title: Aberrantly glycosylated IgG elicits pathogenic signaling in podocytes and signifies lupus nephritis.
  4. CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.
    Title: CaMK4 promotes abortion-related Th17 cell imbalance by activating AKT/mTOR signaling pathway.
  5. CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
    Title: CAMKK2-CAMK4 signaling regulates transferrin trafficking, turnover, and iron homeostasis.
  6. MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
    Title: MiR-507 inhibits the growth and invasion of trophoblasts by targeting CAMK4.
  7. Comparative transcriptome analysis reveals a potential role for CaMK4 in gammadeltaT17 cells from systemic lupus erythematosus patients with lupus nephritis.
    Title: Comparative transcriptome analysis reveals a potential role for CaMK4 in γδT17 cells from systemic lupus erythematosus patients with lupus nephritis.
  8. MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
    Title: MiR-129-5p inhibits liver cancer growth by targeting calcium calmodulin-dependent protein kinase IV (CAMK4).
  9. rs2300782 of gene CAMK4 is associated with diabetic retinopathy incidence and severity among Chinese Hui population.
    Title: Associations of rs2300782 CAMK4, rs2292239 ERBB3 and rs10491034 ARHGAP22 with Diabetic Retinopathy Among Chinese Hui Population.
  10. CaMK4 could be responsible for glycolysis, which contributes to the production of IL-17, and CaMK4 may contribute to aberrant expression of GLUT1 in T cells from patients with active SLE.
    Title: Promotion of Calcium/Calmodulin-Dependent Protein Kinase 4 by GLUT1-Dependent Glycolysis in Systemic Lupus Erythematosus.
Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
EBI GWAS Catalog
Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.
EBI GWAS Catalog
Common variation near ROBO2 is associated with expressive vocabulary in infancy.
EBI GWAS Catalog
Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness.
EBI GWAS Catalog
Genome-wide association study of chronic periodontitis in a general German population.
EBI GWAS Catalog
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36771

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in myeloid dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
NOT involved_in positive regulation of myeloid dendritic cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of T cell differentiation in thymus TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of osteoclast differentiation TAS
Traceable Author Statement
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
calcium/calmodulin-dependent protein kinase type IV
Names
CAM kinase IV
CAM kinase- GR
brain Ca(2+)-calmodulin-dependent protein kinase type IV
brain Ca++-calmodulin-dependent protein kinase type IV
calcium/calmodulin-dependent protein kinase type IV catalytic chain
NP_001310303.1
NP_001310304.1
NP_001310305.1
NP_001310306.1
NP_001735.1
XP_047273739.1
XP_054209545.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001323374.2 → NP_001310303.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010468, AC011422, BQ018740, BX374853, L24959
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    D3DSZ7, Q16566
    UniProtKB/TrEMBL
    B2R747
    Related
    ENSP00000422634.1, ENST00000512453.5
    Conserved Domains (2) summary
    cd14085
    Location:42 → 335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46 → 300
    Pkinase; Protein kinase domain

  2. NM_001323375.2 → NP_001310304.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC010275, AC010468, AC011422, BQ018740
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    D3DSZ7, Q16566
    UniProtKB/TrEMBL
    B2R747
    Conserved Domains (2) summary
    cd14085
    Location:42 → 335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46 → 300
    Pkinase; Protein kinase domain

  3. NM_001323376.2 → NP_001310305.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC011422, AK311662, BQ018740, BX374853
    Conserved Domains (1) summary
    cl21453
    Location:1 → 138
    PKc_like; Protein Kinases, catalytic domain

  4. NM_001323377.2 → NP_001310306.1  calcium/calmodulin-dependent protein kinase type IV isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC010275, AC010468, AC011422, BQ018740
    Conserved Domains (1) summary
    cl21453
    Location:1 → 138
    PKc_like; Protein Kinases, catalytic domain

  5. NM_001744.6 → NP_001735.1  calcium/calmodulin-dependent protein kinase type IV isoform 1

    See identical proteins and their annotated locations for NP_001735.1

    Status: REVIEWED

    Source sequence(s)
    AC011422, BC025687, BQ018740, DA396146
    Consensus CDS
    CCDS4103.1
    UniProtKB/Swiss-Prot
    D3DSZ7, Q16566
    UniProtKB/TrEMBL
    B2R747
    Related
    ENSP00000282356.4, ENST00000282356.9
    Conserved Domains (2) summary
    cd14085
    Location:42 → 335
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
    pfam00069
    Location:46 → 300
    Pkinase; Protein kinase domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    111223583..111494886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417783.1 → XP_047273739.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

RNA

  1. XR_948303.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    111734219..112005186
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353570.1 → XP_054209545.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

RNA

  1. XR_008487178.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16566.1 GenPept UniProtKB/Swiss-Prot:Q16566

Gene LinkOut

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