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OR4F16 olfactory receptor family 4 subfamily F member 16 [ Homo sapiens (human) ]

Gene ID: 81399, updated on 11-Apr-2024

Summary

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Official Symbol
OR4F16provided by HGNC
Official Full Name
olfactory receptor family 4 subfamily F member 16provided by HGNC
Primary source
HGNC:HGNC:15079
See related
Ensembl:ENSG00000284662 AllianceGenome:HGNC:15079
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-1; OR7-21
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
1p36.33
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (676076..720101, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111940..112877, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (621096..622034, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:569139-570114 Neighboring gene MT-ATP6 pseudogene 1 Neighboring gene MT-CO3 pseudogene 12 Neighboring gene NANOG hESC enhancer GRCh37_chr1:581712-582213 Neighboring gene WBP1L pseudogene 6 Neighboring gene NANOG hESC enhancer GRCh37_chr1:632454-632965 Neighboring gene septin 14 pseudogene 14 Neighboring gene uncharacterized LOC100288069 Neighboring gene capicua transcriptional repressor pseudogene 3 Neighboring gene RNA, U6 small nuclear 1199, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  3. Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer. Vichas A, et al. Nat Commun, 2021 Aug 9. PMID 34373451, Free PMC Article
  4. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
olfactory receptor 4F3/4F16/4F29
Names
olfactory receptor OR1-1
olfactory receptor OR4F16
olfactory receptor OR7-21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005277.1 → NP_001005277.1  olfactory receptor 4F3/4F16/4F29

    See identical proteins and their annotated locations for NP_001005277.1

    Status: VALIDATED

    Source sequence(s)
    AC114498
    Consensus CDS
    CCDS41221.1
    UniProtKB/Swiss-Prot
    B2RPQ6, Q6IEY1
    UniProtKB/TrEMBL
    A0A126GV92, Q6IFP3
    Related
    ENSP00000329982.2, ENST00000332831.5
    Conserved Domains (1) summary
    cd15226
    Location:35 → 291
    7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    676076..720101 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449992.2 → XP_024305760.1  olfactory receptor 4F3/4F16/4F29 isoform X1

    UniProtKB/Swiss-Prot
    B2RPQ6, Q6IEY1
    UniProtKB/TrEMBL
    A0A126GV92, Q6IFP3
    Conserved Domains (1) summary
    cd15226
    Location:35 → 291
    7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_017002410.2 → XP_016857899.1  olfactory receptor 4F3/4F16/4F29 isoform X1

    UniProtKB/Swiss-Prot
    B2RPQ6, Q6IEY1
    UniProtKB/TrEMBL
    A0A126GV92, Q6IFP3
    Conserved Domains (1) summary
    cd15226
    Location:35 → 291
    7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. XM_017002408.2 → XP_016857897.1  olfactory receptor 4F3/4F16/4F29 isoform X1

    UniProtKB/Swiss-Prot
    B2RPQ6, Q6IEY1
    UniProtKB/TrEMBL
    A0A126GV92, Q6IFP3
    Conserved Domains (1) summary
    cd15226
    Location:35 → 291
    7tmA_OR4-like; olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

  4. XM_047431162.1 → XP_047287118.1  olfactory receptor 4F3/4F16/4F29 isoform X1

    UniProtKB/Swiss-Prot
    B2RPQ6, Q6IEY1
    UniProtKB/TrEMBL
    A0A126GV92

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    111940..112877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6IEY1.1 GenPept UniProtKB/Swiss-Prot:Q6IEY1

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