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PF3D7_0523000 multidrug resistance protein 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 813045, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0523000
Gene description
multidrug resistance protein 1
Locus tag
PF3D7_0523000
See related
PlasmoDB:PF3D7_0523000; VEuPathDB:PF3D7_0523000
Gene type
protein coding
RNA name
multidrug resistance protein 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0523000 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
1
Sequence:
Chromosome: 5; NC_004326.2 (957890..962149)

Chromosome 5 - NC_004326.2Genomic Context describing neighboring genes Neighboring gene pre-mRNA-splicing factor BUD31, putative Neighboring gene zinc finger protein, putative Neighboring gene mitochondrial-processing peptidase subunit alpha, putative Neighboring gene heptatricopeptide repeat-containing protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004326.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Association between the pfmdr1 gene and in vitro artemether and lumefantrine sensitivity in Thai isolates of Plasmodium falciparum. Mungthin M, et al. Am J Trop Med Hyg, 2010 Nov. PMID 21036827, Free PMC Article
  2. The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa. Okombo J, et al. Antimicrob Agents Chemother, 2013 Sep. PMID 23836177, Free PMC Article
  3. Plasmodium falciparum with multidrug resistance 1 gene duplications, Senegal. Pascual A, et al. Emerg Infect Dis, 2013 May. PMID 23697703, Free PMC Article
  4. Association between prevalence of chloroquine resistance and unusual mutation in pfmdr-I and pfcrt genes in India. Das S, et al. Am J Trop Med Hyg, 2013 May. PMID 23509121, Free PMC Article
  5. Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections. Pillai DR, et al. Malar J, 2012 Apr 27. PMID 22540925, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
    Title: Increase in the proportion of Plasmodium falciparum with kelch13 C580Y mutation and decline in pfcrt and pfmdr1 mutant alleles in Papua New Guinea.
  2. Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.
    Title: Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asia with Increased Substrate Transport.
  3. Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
    Title: Molecular surveillance of anti-malarial resistance pfcrt, pfmdr1, and pfk13 polymorphisms in African Plasmodium falciparum imported parasites to Wuhan, China.
  4. Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
    Title: Selection of pfcrt K76 and pfmdr1 N86 Coding Alleles after Uncomplicated Malaria Treatment by Artemether-Lumefantrine in Mali.
  5. Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
    Title: Molecular detection of drug resistant polymorphisms in Plasmodium falciparum isolates from Southwest, Nigeria.
  6. Spatio-temporal screening of Plasmodium population with PfMDR1 single nucleotide polymorphism accounts for its association with antimalarial susceptibility.
    Title: Spatio-temporal distribution of PfMDR1 polymorphism among uncomplicated Plasmodium falciparum malaria cases along international border of north east India.
  7. N86Y mutation augments resistance to the artemisinin-based combination therapy partner drug amodiaquine and the former first-line agent chloroquine; N86Y increases parasite susceptibility to the partner drugs lumefantrine and mefloquine, and the active artemisinin metabolite dihydroartemisinin
    Title: Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
  8. Pfmdr1 is a pivotal factor in malaria resistance to artemisinin combination therapies. (Review)
    Title: pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies.
  9. Altered Plasmodium falciparum sensitivity to the antiretroviral protease inhibitor lopinavir associated with polymorphisms in PfMDR1.
    Title: Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1.
  10. No significant association between the pfmdr1 copy number and piperaquine IC50 values was found. In contrast, the parasites containing the pfmdr1 86Y allele exhibited significantly reduced piperaquine sensitivity.
    Title: Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.
Submit: New GeneRIF Correction See all GeneRIFs (59)

General gene information

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Markers

Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables ATPase-coupled transmembrane transporter activity ISM
Inferred from Sequence Model
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in food vacuole HDA PubMed 
located_in food vacuole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISM
Inferred from Sequence Model
more info
  
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
multidrug resistance protein 1
XP_001351787.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004326.2 Reference assembly

    Range
    957890..962149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001351751.1 → XP_001351787.1  multidrug resistance protein 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001351787.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P13568
    UniProtKB/TrEMBL
    A0A0L1IG68, A0A0L7M770, D5L5S6, F1C8M9, Q7K6A5, W7JYG0
    Conserved Domains (1) summary
    PTZ00265
    Location:1 → 1419
    PTZ00265; multidrug resistance protein (mdr1); Provisional
Nucleotide Protein
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