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PF3D7_1247400 peptidyl-prolyl cis-trans isomerase FKBP35 [ Plasmodium falciparum 3D7 ]

Gene ID: 811507, updated on 18-Sep-2024

Summary

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Gene symbol
PF3D7_1247400
Gene description
peptidyl-prolyl cis-trans isomerase FKBP35
Locus tag
PF3D7_1247400
See related
PlasmoDB:PF3D7_1247400; VEuPathDB:PF3D7_1247400
Gene type
protein coding
RNA name
peptidyl-prolyl cis-trans isomerase FKBP35
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_1247400 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
1
Sequence:
Chromosome: 12; NC_037284.1 (1955124..1956038, complement)

Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene conserved protein, unknown function Neighboring gene hypothetical protein Neighboring gene serine/threonine protein kinase, putative Neighboring gene conserved Plasmodium protein, unknown function

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037284.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Targeted Covalent Inhibition of Plasmodium FK506 Binding Protein 35. Atack TC, et al. ACS Med Chem Lett, 2020 Nov 12. PMID 33209191, Free PMC Article
  2. Expression, purification, and molecular characterization of Plasmodium falciparum FK506-binding protein 35 (PfFKBP35). Yoon HR, et al. Protein Expr Purif, 2007 May. PMID 17289400
  3. A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities. Monaghan P, et al. Mol Biochem Parasitol, 2005 Feb. PMID 15664653
  4. The FK506-binding protein of the malaria parasite, Plasmodium falciparum, is a FK506-sensitive chaperone with FK506-independent calcineurin-inhibitory activity. Kumar R, et al. Mol Biochem Parasitol, 2005 Jun. PMID 15850699
  5. Identification of Plasmodium falciparum nuclear proteins by mass spectrometry and proposed protein annotation. Briquet S, et al. PLoS One, 2018. PMID 30379851, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. characterisation of the first member of the FKBP family identified in Plasmodium falciparum
    Title: A Plasmodium falciparum FK506-binding protein (FKBP) with peptidyl-prolyl cis-trans isomerase and chaperone activities.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables FK506 binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within protein folding IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
peptidyl-prolyl cis-trans isomerase FKBP35
XP_001350859.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037284.1 Reference assembly

    Range
    1955124..1956038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350823.1 → XP_001350859.1  peptidyl-prolyl cis-trans isomerase FKBP35 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350859.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    Q8I4V8
    UniProtKB/TrEMBL
    A0A024V445, A0A024VEX6, A0A024W3L4, A0A024WMR5, A0A024X4E7, A0A0L1IEI2, A0A0L7KF76, W4IE55, W4J3A4, W7F4A3, W7G1A9, W7JR25, W7JUC3
    Conserved Domains (3) summary
    TIGR00990
    Location:131 → 284
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:148 → 172
    TPR; TPR repeat [structural motif]
    pfam00254
    Location:34 → 123
    FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
Nucleotide Protein
Heading Accession and Version

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