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PF3D7_1224000 GTP cyclohydrolase 1 [ Plasmodium falciparum 3D7 ]

Gene ID: 811283, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_1224000
Gene description
GTP cyclohydrolase 1
Locus tag
PF3D7_1224000
See related
PlasmoDB:PF3D7_1224000; VEuPathDB:PF3D7_1224000
Gene type
protein coding
RNA name
GTP cyclohydrolase 1
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_1224000 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
1
Sequence:
Chromosome: 12; NC_037284.1 (974372..975541)

Chromosome 12 - NC_037284.1Genomic Context describing neighboring genes Neighboring gene citrate/oxoglutarate carrier protein, putative Neighboring gene 50S ribosomal protein L24, putative Neighboring gene conserved protein, unknown function Neighboring gene BRO1 domain-containing protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037284.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Amplification of GTP-cyclohydrolase 1 gene in Plasmodium falciparum isolates with the quadruple mutant of dihydrofolate reductase and dihydropteroate synthase genes in Ghana. Osei M, et al. PLoS One, 2018. PMID 30265714, Free PMC Article
  2. Biochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase I. Kümpornsin K, et al. Malar J, 2014 Apr 19. PMID 24745605, Free PMC Article
  3. A Prioritized and Validated Resource of Mitochondrial Proteins in Plasmodium Identifies Unique Biology. van Esveld SL, et al. mSphere, 2021 Oct 27. PMID 34494883, Free PMC Article
  4. Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite Plasmodium falciparum. Oehring SC, et al. Genome Biol, 2012 Nov 26. PMID 23181666, Free PMC Article
  5. Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, et al. Nature, 2002 Oct 3. PMID 12368864, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables GTP cyclohydrolase I activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
GTP cyclohydrolase 1
XP_001350637.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_037284.1 Reference assembly

    Range
    974372..975541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001350601.1 → XP_001350637.1  GTP cyclohydrolase 1 [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_001350637.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A024V5Z2, A0A024VMT3, A0A024W5M0, A0A024WNI0, A0A024X515, A0A0L7KCU3, O97071, Q8I5H7, W4I7L8, W4J145, W7J8P3, W7JRH3
    Conserved Domains (1) summary
    cl00263
    Location:200 → 374
    TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials