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Dusp12 dual specificity phosphatase 12 [ Mus musculus (house mouse) ]

Gene ID: 80915, updated on 20-May-2024

Summary

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Official Symbol
Dusp12provided by MGI
Official Full Name
dual specificity phosphatase 12provided by MGI
Primary source
MGI:MGI:1890614
See related
Ensembl:ENSMUSG00000026659 AllianceGenome:MGI:1890614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VH1; mVH1; ESTM36; T-DSP4; LMW-DSP4; 1190004O14Rik
Summary
Enables protein tyrosine/serine/threonine phosphatase activity. Predicted to be involved in positive regulation of glucokinase activity and protein dephosphorylation. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system and retina. Orthologous to human DUSP12 (dual specificity phosphatase 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 13.9), CNS E18 (RPKM 12.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dusp12 in Genome Data Viewer
Location:
1 H3; 1 77.27 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170701756..170713109, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170874187..170885540, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene activating transcription factor 6 Neighboring gene STARR-positive B cell enhancer ABC_E4381 Neighboring gene STARR-positive B cell enhancer ABC_E7774 Neighboring gene predicted gene, 29733 Neighboring gene STARR-positive B cell enhancer ABC_E7775 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene Fc receptor-like B Neighboring gene Fc receptor-like A Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dual-specificity phosphatase 12 attenuates oxidative stress injury and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38 signaling pathway. Li H, et al. Free Radic Biol Med, 2022 Nov 1. PMID 36108935
  2. DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway. Boldorini R, et al. Clin Sci (Lond), 2021 Jan 15. PMID 33416082, Free PMC Article
  3. DUSP12 protects against hepatic ischemia-reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo. Qiu T, et al. Clin Sci (Lond), 2020 Sep 18. PMID 32803262
  4. mVH1, a dual-specificity phosphatase whose expression is cell cycle regulated. Zhang XM, et al. Mamm Genome, 2000 Dec. PMID 11130991
  5. Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload. Li WM, et al. Clin Sci (Lond), 2017 Jan 1. PMID 27702885

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway.
    Title: Increasing expression of dual-specificity phosphatase 12 mitigates oxygen-glucose deprivation/reoxygenation-induced neuronal apoptosis and inflammation through inactivation of the ASK1-JNK/p38 MAPK pathway.
  2. Dual-specificity phosphatase 12 attenuates oxidative stress injury and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38 signaling pathway.
    Title: Dual-specificity phosphatase 12 attenuates oxidative stress injury and apoptosis in diabetic cardiomyopathy via the ASK1-JNK/p38 signaling pathway.
  3. DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway.
    Title: DUSP12 acts as a novel endogenous protective signal against hepatic ischemia-reperfusion damage by inhibiting ASK1 pathway.
  4. DUSP12 protects against hepatic ischemia-reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo.
    Title: DUSP12 protects against hepatic ischemia-reperfusion injury dependent on ASK1-JNK/p38 pathway in vitro and in vivo.
  5. The regulatory role of DUSP12 is primarily through c-Jun N-terminal kinase (JNK) inhibition.
    Title: Dual specific phosphatase 12 ameliorates cardiac hypertrophy in response to pressure overload.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC117646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine/serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein phosphatase 12
Names
dual specificity phosphatase T-DSP4
dual specificity phosphatase VH1
NP_001343414.1
NP_001343415.1
NP_075662.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356485.1 → NP_001343414.1  dual specificity protein phosphatase 12 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Conserved Domains (1) summary
    cd00127
    Location:26 → 165
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

  2. NM_001356486.1 → NP_001343415.1  dual specificity protein phosphatase 12 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Conserved Domains (1) summary
    cl21483
    Location:1 → 40
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_023173.2 → NP_075662.2  dual specificity protein phosphatase 12 isoform 1

    See identical proteins and their annotated locations for NP_075662.2

    Status: VALIDATED

    Source sequence(s)
    BC099453
    Consensus CDS
    CCDS15474.1
    UniProtKB/Swiss-Prot
    Q9D0T2, Q9EQD3
    UniProtKB/TrEMBL
    Q4KL39
    Related
    ENSMUSP00000027970.8, ENSMUST00000027970.14
    Conserved Domains (1) summary
    cd00127
    Location:26 → 165
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. NR_151476.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113490
    Related
    ENSMUST00000046476.13

  2. NR_151477.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC113490

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170701756..170713109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D0T2.1 GenPept UniProtKB/Swiss-Prot:Q9D0T2

Gene LinkOut

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