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TAS1R1 taste 1 receptor member 1 [ Homo sapiens (human) ]

Gene ID: 80835, updated on 11-Apr-2024

Summary

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Official Symbol
TAS1R1provided by HGNC
Official Full Name
taste 1 receptor member 1provided by HGNC
Primary source
HGNC:HGNC:14448
See related
Ensembl:ENSG00000173662 MIM:606225; AllianceGenome:HGNC:14448
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR1; T1R1; GM148; GPR70
Summary
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Expression
Biased expression in testis (RPKM 1.2), gall bladder (RPKM 0.1) and 7 other tissues See more
Orthologs
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Genomic context

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Location:
1p36.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (6555307..6579755)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (6080965..6105419)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (6615367..6639815)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6534424-6534945 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6534946-6535466 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:6536823-6538022 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 159 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 160 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr1:6555381-6556136 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 161 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6562565-6563294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6566857-6567357 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6571620-6572434 Neighboring gene MPRA-validated peak31 silencer Neighboring gene Sharpr-MPRA regulatory region 8211 Neighboring gene Sharpr-MPRA regulatory region 5048 Neighboring gene nucleolar protein 9 Neighboring gene RNA, U6 small nuclear 731, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:6612384-6612884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 162 Neighboring gene uncharacterized LOC107984912 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:6639438-6640137 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 83 Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:6658990-6660189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 85 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 164 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 165 Neighboring gene kelch like family member 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of taste receptor gene polymorphisms with dental caries. Arid J, et al. Braz Oral Res, 2020. PMID 32578798
  2. Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population. Choi JH, et al. Mol Nutr Food Res, 2016 Nov. PMID 27321875
  3. Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity? Rawal S, et al. Chem Senses, 2013 Oct. PMID 24000232, Free PMC Article
  4. Functional crosstalk between GPCRs: with or without oligomerization. Prezeau L, et al. Curr Opin Pharmacol, 2010 Feb. PMID 19962942
  5. Genetic and molecular basis of individual differences in human umami taste perception. Shigemura N, et al. PLoS One, 2009 Aug 21. PMID 19696921, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
    Title: Gene expression analyses of TAS1R taste receptors relevant to the treatment of cardiometabolic disease.
  2. Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
    Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
  3. Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.
    Title: Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes.
  4. Association of taste receptor gene polymorphisms with dental caries.
    Title: Association of taste receptor gene polymorphisms with dental caries.
  5. Using homology modeling, molecular docking and molecular dynamics (MD) simulations, this study investigates the effects of five natural umami ligands on the structural dynamics of T1R1-T1R3.
    Title: Understanding the molecular mechanism of umami recognition by T1R1-T1R3 using molecular dynamics simulations.
  6. Studied association of taste 1 receptor member 1 (TAS1R1) and taste 1 receptor member 3 (TAS1R3) single nucleotide polymorphisms (SNPs) with food choices at a buffet meal. and found certain TAS1R1 and TAS1R3 SNPs to be associated with fat and savoury-tasting and protein-rich food choices following a laboratory buffet in humans.
    Title: TAS1R1 and TAS1R3 Polymorphisms Relate to Energy and Protein-Rich Food Choices from a Buffet Meal Respectively.
  7. Genetic variants in TAS1R were associated with dietary consumption, which may be associated with gastric cancer risk
    Title: Variations in TAS1R taste receptor gene family modify food intake and gastric cancer risk in a Korean population.
  8. The study provides human psychophysical evidence that TAS1R1 polymorphisms associate with modest differences in overall taste intensity, which were independent from other well-studied markers of variation in oral sensation.
    Title: Do polymorphisms in the TAS1R1 gene contribute to broader differences in human taste intensity?
  9. A complex molecular mechanism involving changes in the properties of both the orthosteric and non-orthosteric sites of T1R1 underlies the determination of ligand specificity in mammalian T1R1/T1R3.
    Title: Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor).
  10. Data show that that Tas1r1 and Tas1r3 are expressed in murine and human spermatozoa.
    Title: Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²⁺ and cAMP concentrations in spermatozoa.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables taste receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of taste IEA
Inferred from Electronic Annotation
more info
  
involved_in sensory perception of umami taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of umami taste IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
taste receptor type 1 member 1
Names
G-protein coupled receptor 70
seven transmembrane helix receptor
taste receptor, type 1, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138697.4 → NP_619642.2  taste receptor type 1 member 1 isoform b precursor

    See identical proteins and their annotated locations for NP_619642.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AI742401, AL591866, BC136515, BC136516
    Consensus CDS
    CCDS81.1
    UniProtKB/Swiss-Prot
    B2RMX0, Q5SY22, Q5SY24, Q7RTX1, Q8NGZ7, Q8TDJ7, Q8TDJ8, Q8TDJ9, Q8TDK0
    UniProtKB/TrEMBL
    B2RE49
    Related
    ENSP00000331867.6, ENST00000333172.11
    Conserved Domains (4) summary
    cd06363
    Location:32 → 486
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam00003
    Location:588 → 814
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:74 → 457
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:495 → 544
    NCD3G; Nine Cysteines Domain of family 3 GPCR

  2. NM_177540.3 → NP_803884.1  taste receptor type 1 member 1 isoform c precursor

    See identical proteins and their annotated locations for NP_803884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 2, resulting in an isoform (c) which is shorter but has the same N- and C-termini compared to isoform b.
    Source sequence(s)
    AI742401, AK292014, AL591866, BC136515
    Consensus CDS
    CCDS82.1
    UniProtKB/TrEMBL
    A8K7J9
    Related
    ENSP00000312558.5, ENST00000351136.7
    Conserved Domains (3) summary
    pfam00003
    Location:334 → 560
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam07562
    Location:241 → 290
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:32 → 166
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    6555307..6579755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011542206.3 → XP_011540508.2  taste receptor type 1 member 1 isoform X2

  2. XM_011542203.2 → XP_011540505.1  taste receptor type 1 member 1 isoform X1

    See identical proteins and their annotated locations for XP_011540505.1

    UniProtKB/TrEMBL
    B2RE49
    Conserved Domains (4) summary
    pfam00003
    Location:510 → 736
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:1 → 379
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:417 → 466
    NCD3G; Nine Cysteines Domain of family 3 GPCR
    cl10011
    Location:1 → 408
    Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    6080965..6105419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338885.1 → XP_054194860.1  taste receptor type 1 member 1 isoform X2

  2. XM_054338884.1 → XP_054194859.1  taste receptor type 1 member 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177539.1: Suppressed sequence

    Description
    NM_177539.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

  2. NM_177541.1: Suppressed sequence

    Description
    NM_177541.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTX1.1 GenPept UniProtKB/Swiss-Prot:Q7RTX1

Gene LinkOut

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