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TAS1R2 taste 1 receptor member 2 [ Homo sapiens (human) ]

Gene ID: 80834, updated on 11-Apr-2024

Summary

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Official Symbol
TAS1R2provided by HGNC
Official Full Name
taste 1 receptor member 2provided by HGNC
Primary source
HGNC:HGNC:14905
See related
Ensembl:ENSG00000179002 MIM:606226; AllianceGenome:HGNC:14905
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TR2; T1R2; GPR71
Summary
Contributes to sweet taste receptor activity. Involved in detection of chemical stimulus involved in sensory perception of sweet taste and positive regulation of cytokinesis. Part of sweet taste receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
1p36.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (18839599..18859660, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (18659394..18679451, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19166093..19186154, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene dynein light chain LC8-type 1 pseudogene 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18877005-18877829 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18879379-18879880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18879881-18880380 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18883865-18884372 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18884373-18884880 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18898371-18898870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18901646-18902224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18902225-18902802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18925717-18926246 Neighboring gene PAX7 promoter region Neighboring gene PAX7 intron homotypic clusters of transcription factor binding sites enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18962444-18963061 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18963062-18963678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18963679-18964296 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:18967445-18967966 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:18976025-18976654 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:18978097-18978886 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:18979869-18980025 Neighboring gene Sharpr-MPRA regulatory region 1855 Neighboring gene paired box 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19018361-19018860 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19064331-19064838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19064839-19065345 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19066201-19066702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19119189-19119690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19119691-19120190 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19144000-19144500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19146197-19146706 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19146707-19147216 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19147395-19147573 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19176158-19176291 Neighboring gene Sharpr-MPRA regulatory region 7483 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19210623-19210854 Neighboring gene aldehyde dehydrogenase 4 family member A1 Neighboring gene microRNA 4695 Neighboring gene microRNA 1290

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study. Liang Y, et al. BMC Oral Health, 2022 Nov 5. PMID 36335309, Free PMC Article
  2. Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor. Laffitte A, et al. Int J Mol Sci, 2022 Aug 16. PMID 36012481, Free PMC Article
  3. The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans. Serrano J, et al. Mol Metab, 2021 Dec. PMID 34509698, Free PMC Article
  4. Structure-based screening for discovery of sweet compounds. Ben Shoshan-Galeczki Y, et al. Food Chem, 2020 Jun 15. PMID 32018080
  5. Sweet Taste Receptor TAS1R2 Polymorphism (Val191Val) Is Associated with a Higher Carbohydrate Intake and Hypertriglyceridemia among the Population of West Mexico. Ramos-Lopez O, et al. Nutrients, 2016 Feb 19. PMID 26907331, Free PMC Article

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
    Title: Altered expression levels of TAS1R2 and TAS1R3 genes among SARS-CoV-2 variants of concerns.
  2. The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
    Title: The rs35874116 single nucleotide polymorphism increases sweet intake and the risk of severe early childhood caries: a case-control study.
  3. Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
    Title: Functional Characterization of the Venus Flytrap Domain of the Human TAS1R2 Sweet Taste Receptor.
  4. Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
    Title: Relationship between the TAS2R38 and TAS1R2 polymorphisms and the dental status in obese children.
  5. The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
    Title: The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans.
  6. Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
    Title: Polymorphic variants in Sweet and Umami taste receptor genes and birthweight.
  7. Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
    Title: Current Progress in Understanding the Structure and Function of Sweet Taste Receptor.
  8. Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
    Title: Binding Hotspot and Activation Mechanism of Maltitol and Lactitol toward the Human Sweet Taste Receptor.
  9. Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
    Title: Modeling and Structural Characterization of the Sweet Taste Receptor Heterodimer.
  10. create several models of the orthosteric binding site of the sweet taste receptor in the hT1R2 VFT domain
    Title: Structure-based screening for discovery of sweet compounds.
Submit: New GeneRIF Correction See all GeneRIFs (35)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic variants associated with disordered eating.
EBI GWAS Catalog
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sweet taste receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to sweet taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to taste receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables taste receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IC
Inferred by Curator
more info
 PubMed 
involved_in detection of chemical stimulus involved in sensory perception of sweet taste IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sweet taste IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of sweet taste IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IC
Inferred by Curator
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of sweet taste receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of sweet taste receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
taste receptor type 1 member 2
Names
G-protein coupled receptor 71
sweet taste receptor T1R2
taste receptor, type 1, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152232.6 → NP_689418.2  taste receptor type 1 member 2 precursor

    See identical proteins and their annotated locations for NP_689418.2

    Status: VALIDATED

    Source sequence(s)
    AL831755, BX537160
    Consensus CDS
    CCDS187.1
    UniProtKB/Swiss-Prot
    Q5TZ19, Q8TE23
    Related
    ENSP00000364520.3, ENST00000375371.4
    Conserved Domains (4) summary
    cd06363
    Location:27 → 484
    PBP1_Taste_receptor; Ligand-binding domain of the T1R taste receptor
    pfam00003
    Location:577 → 814
    7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
    pfam01094
    Location:70 → 454
    ANF_receptor; Receptor family ligand binding region
    pfam07562
    Location:493 → 543
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    18839599..18859660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    18659394..18679451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TE23.2 GenPept UniProtKB/Swiss-Prot:Q8TE23

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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