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ZNF436 zinc finger protein 436 [ Homo sapiens (human) ]

Gene ID: 80818, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF436provided by HGNC
Official Full Name
zinc finger protein 436provided by HGNC
Primary source
HGNC:HGNC:20814
See related
Ensembl:ENSG00000125945 MIM:611703; AllianceGenome:HGNC:20814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; Zfp46
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 11.7), brain (RPKM 9.2) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
1p36.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23359448..23369836, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23192614..23203014, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23685941..23696329, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1355 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23670710-23671294 Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23683836-23684671 Neighboring gene Sharpr-MPRA regulatory region 11811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 361 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23697210-23697795 Neighboring gene ZNF436 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 362 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23709609-23709825 Neighboring gene transcription elongation factor A3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23745635-23746193 Neighboring gene uncharacterized LOC124903875 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE. Li Y, et al. Mol Biol Rep, 2006 Dec. PMID 17089209
  2. ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. Shang Y, et al. Biochem Biophys Res Commun, 2019 Aug 6. PMID 31178130
  3. MicroRNA-4317 suppresses the progression of hepatocellular carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway. Zhang L, et al. Tissue Cell, 2022 Feb. PMID 34861581
  4. Characterization and mapping of human genes encoding zinc finger proteins. Bray P, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946370, Free PMC Article
  5. Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes. Lichter P, et al. Genomics, 1992 Aug. PMID 1505991

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis.
    Title: Chromosome 1p36 candidate gene ZNF436 predicts the prognosis of neuroblastoma: a bioinformatic analysis.
  2. MicroRNA-4317 suppresses the progression of hepatocellular carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway.
    Title: MicroRNA-4317 suppresses the progression of hepatocellular carcinoma by targeting ZNF436-mediated PI3K/AKT signaling pathway.
  3. ZNF436 has a role in promoting tumor cell proliferation through transcriptional activation of BCL10 in glioma
    Title: ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma.
  4. ZNF436 is a member of the zinc finger transcription factor family and may act as a negative regulator in gene transcription mediated by the MAPK signaling pathways.
    Title: A novel zinc-finger protein ZNF436 suppresses transcriptional activities of AP-1 and SRE.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 436 (ZNF436) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1710

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 436
Names
DNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077195.2 → NP_001070663.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_001070663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB051497, AL109936
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q658I9, Q9C0F3
    Related
    ENSP00000313582.4, ENST00000314011.9
    Conserved Domains (4) summary
    COG5048
    Location:212 → 467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196 → 216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 54
    KRAB; KRAB box
    pfam13465
    Location:152 → 177
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001370652.1 → NP_001357581.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109936
    Related
    ENSP00000518729.1, ENST00000711404.1
    Conserved Domains (5) summary
    smart00349
    Location:1 → 53
    KRAB; krueppel associated box
    COG5048
    Location:194 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178 → 198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:120 → 142
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:134 → 159
    zf-H2C2_2; Zinc-finger double domain

  3. NM_030634.3 → NP_085137.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_085137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109936, AL834485
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q658I9, Q9C0F3
    Related
    ENSP00000363736.3, ENST00000374608.3
    Conserved Domains (4) summary
    COG5048
    Location:212 → 467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196 → 216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:13 → 54
    KRAB; KRAB box
    pfam13465
    Location:152 → 177
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23359448..23369836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p14 PATCHES

    Range
    129427..139815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23192614..23203014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9C0F3.2 GenPept UniProtKB/Swiss-Prot:Q9C0F3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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