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WDCP WD repeat and coiled coil containing [ Homo sapiens (human) ]

Gene ID: 80304, updated on 5-Mar-2024

Summary

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Official Symbol
WDCPprovided by HGNC
Official Full Name
WD repeat and coiled coil containingprovided by HGNC
Primary source
HGNC:HGNC:26157
See related
Ensembl:ENSG00000163026 MIM:616234; AllianceGenome:HGNC:26157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MMAP; PP384; C2orf44
Summary
Enables kinase binding activity. Involved in protein complex oligomerization. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 3.8), lymph node (RPKM 3.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p23.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24029347..24047391, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24064045..24082083, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24252217..24270261, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene UBX domain protein 2A Neighboring gene RNA, 7SL, cytoplasmic 610, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24238941-24239496 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24239497-24240052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:24244092-24244708 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24246333-24247318 Neighboring gene MFSD2 lysolipid transporter B, sphingolipid Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11225 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:24276709-24276900 Neighboring gene FKBP prolyl isomerase 1B Neighboring gene Sharpr-MPRA regulatory region 5215 Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:24298482-24299014 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:24299015-24299546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:24305416-24306346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11227 Neighboring gene splicing factor 3b subunit 6 Neighboring gene family with sequence similarity 228 member B Neighboring gene tumor protein p53 inducible protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Xu R, et al. Proc Natl Acad Sci U S A, 2018 Oct 23. PMID 30297404, Free PMC Article
  2. Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK. Yokoyama N, et al. Biomed Rep, 2015 Jan. PMID 25469238, Free PMC Article
  3. Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies. Lipson D, et al. Nat Med, 2012 Feb 12. PMID 22327622, Free PMC Article
  4. Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Sardiu ME, et al. Proc Natl Acad Sci U S A, 2008 Feb 5. PMID 18218781, Free PMC Article
  5. Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. Scott MP, et al. J Biol Chem, 2002 Aug 2. PMID 12029088

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21945

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein complex oligomerization IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
WD repeat and coiled-coil-containing protein
Names
WD repeat and coiled-coil-containing protein C2orf44
WD repeat-containing protein C2orf44

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142319.2 → NP_001135791.1  WD repeat and coiled-coil-containing protein isoform 2

    See identical proteins and their annotated locations for NP_001135791.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1, resulting in a frameshift. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AI800484, AK025598, BC035698, DB292134
    Consensus CDS
    CCDS46229.1
    UniProtKB/Swiss-Prot
    Q9H6R7
    Related
    ENSP00000385816.3, ENST00000406895.3
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 608
    DUF4613; Domain of unknown function (DUF4613)

  2. NM_025203.3 → NP_079479.1  WD repeat and coiled-coil-containing protein isoform 1

    See identical proteins and their annotated locations for NP_079479.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK025598, BC035698, CX756689, DB292134
    Consensus CDS
    CCDS1705.1
    UniProtKB/Swiss-Prot
    D6W532, Q8IYK0, Q9H6R7, Q9HBP5
    Related
    ENSP00000295148.4, ENST00000295148.9
    Conserved Domains (1) summary
    pfam15390
    Location:2 → 672
    DUF4613; Domain of unknown function (DUF4613)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    24029347..24047391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    24064045..24082083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6R7.1 GenPept UniProtKB/Swiss-Prot:Q9H6R7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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