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Gpr146 G protein-coupled receptor 146 [ Mus musculus (house mouse) ]

Gene ID: 80290, updated on 28-Oct-2024

Summary

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Official Symbol
Gpr146provided by MGI
Official Full Name
G protein-coupled receptor 146provided by MGI
Primary source
MGI:MGI:1933113
See related
Ensembl:ENSMUSG00000044197 AllianceGenome:MGI:1933113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR8; D830046C22Rik
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway and regulation of cholesterol biosynthetic process. Located in plasma membrane. Orthologous to human GPR146 (G protein-coupled receptor 146). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in lung adult (RPKM 19.7), mammary gland adult (RPKM 13.5) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Gpr146 in Genome Data Viewer
Location:
5 G2; 5 78.49 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (139363452..139382170)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (139377697..139396415)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110082I17 gene Neighboring gene cytochrome P450, family 2, subfamily w, polypeptide 1 Neighboring gene microRNA 339 Neighboring gene STARR-positive B cell enhancer ABC_E9657 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:139858915-139859024 Neighboring gene RIKEN cDNA C130050O18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:139894778-139894979 Neighboring gene G protein-coupled estrogen receptor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice. Han F, et al. Cell Res, 2020 Apr. PMID 32203133, Free PMC Article
  2. Investigation into the presence and functional significance of proinsulin C-peptide in the female germline†. Martin JH, et al. Biol Reprod, 2019 May 1. PMID 30715203
  3. GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase. Huang J, et al. Eur J Pharmacol, 2023 Dec 15. PMID 37926274
  4. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis. Yu H, et al. Cell, 2019 Nov 27. PMID 31778654, Free PMC Article
  5. Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway. Huang H, et al. Immunology, 2017 Sep. PMID 28464285, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
    Title: GPR146 regulates pulmonary vascular remodeling by promoting pulmonary artery smooth muscle cell proliferation through 5-lipoxygenase.
  2. Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
    Title: Hypercholesterolemia risk-associated GPR146 is an orphan G-protein coupled receptor that regulates blood cholesterol levels in humans and mice.
  3. these findings outline a regulatory role for the GPR146/ERK axis in systemic cholesterol metabolism.
    Title: GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.
  4. GPR146 has an antiviral role in fighting against viral infection, although the GPR146-mediated protection is eliminated by IRF3/HES1-signalling.
    Title: Elimination of GPR146-mediated antiviral function through IRF3/HES1-signalling pathway.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7)  1 citation
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC7035, MGC182532, MGC182544

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in regulation of cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 146

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038703.3 → NP_001033792.1  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_001033792.1

    Status: VALIDATED

    Source sequence(s)
    AC140216
    Consensus CDS
    CCDS19809.1
    UniProtKB/Swiss-Prot
    Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
    UniProtKB/TrEMBL
    Q3U2L7
    Related
    ENSMUSP00000098083.3, ENSMUST00000100514.3
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001362206.1 → NP_001349135.1  probable G-protein coupled receptor 146

    Status: VALIDATED

    Source sequence(s)
    AC140216, AC161058
    Consensus CDS
    CCDS19809.1
    UniProtKB/Swiss-Prot
    Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
    UniProtKB/TrEMBL
    Q3U2L7
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

  3. NM_030258.5 → NP_084534.2  probable G-protein coupled receptor 146

    See identical proteins and their annotated locations for NP_084534.2

    Status: VALIDATED

    Source sequence(s)
    AC161058, AK155876, BB738958
    Consensus CDS
    CCDS19809.1
    UniProtKB/Swiss-Prot
    Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
    UniProtKB/TrEMBL
    Q3U2L7
    Related
    ENSMUSP00000049707.8, ENSMUST00000051293.8
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

RNA

  1. NR_033147.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant is represented as non-coding because it lacks the open reading frame found in the other variants.
    Source sequence(s)
    AK086028, AK087317
    Related
    ENSMUST00000188655.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    139363452..139382170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254916.2 → XP_030110776.1  probable G-protein coupled receptor 146 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3K8, Q3U421, Q8BHR6, Q8BHU4, Q99LE2
    UniProtKB/TrEMBL
    Q3U2L7
    Conserved Domains (1) summary
    cd14990
    Location:27 → 305
    7tmA_GPR146; G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177097.3: Suppressed sequence

    Description
    NM_177097.3: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LE2.2 GenPept UniProtKB/Swiss-Prot:Q99LE2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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