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ZNF430 zinc finger protein 430 [ Homo sapiens (human) ]

Gene ID: 80264, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF430provided by HGNC
Official Full Name
zinc finger protein 430provided by HGNC
Primary source
HGNC:HGNC:20808
See related
Ensembl:ENSG00000118620 AllianceGenome:HGNC:20808
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in substantia nigra development. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 6.0), thyroid (RPKM 5.3) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19p12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21020657..21060050)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21159242..21198699)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21203463..21242856)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 40 Neighboring gene uncharacterized LOC112268247 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21183049-21183582 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203153-21203746 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:21203747-21204338 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21206984-21207484 Neighboring gene vomeronasal 1 receptor 80 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14381 Neighboring gene zinc finger protein 714 Neighboring gene RNA, 5S ribosomal pseudogene 469

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis. Chen S, et al. Neurochem Res, 2012 Dec. PMID 22926577
  2. A whole genome screen for HIV restriction factors. Liu L, et al. Retrovirology, 2011 Nov 14. PMID 22082156, Free PMC Article
  3. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. Pech MF, et al. Elife, 2019 Aug 27. PMID 31452512, Free PMC Article
  4. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 430 (ZNF430) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13659, MGC133232, DKFZp762K012

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in substantia nigra development HEP PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 430

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172671.2 → NP_001166142.1  zinc finger protein 430 isoform 2

    See identical proteins and their annotated locations for NP_001166142.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) lacks one internal amino acid, compared to isoform 1.
    Source sequence(s)
    AC012627, AK290475, BC111776, DB255551
    UniProtKB/TrEMBL
    Q2NKJ9
    Conserved Domains (5) summary
    smart00349
    Location:35 → 95
    KRAB; krueppel associated box
    COG5048
    Location:201 → 561
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:290 → 310
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:247 → 271
    zf-H2C2_2; Zinc-finger double domain

  2. NM_025189.4 → NP_079465.3  zinc finger protein 430 isoform 1

    See identical proteins and their annotated locations for NP_079465.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC012627, AK290475, DB255551
    Consensus CDS
    CCDS32978.1
    UniProtKB/Swiss-Prot
    Q86V70, Q9H8G1
    Related
    ENSP00000261560.4, ENST00000261560.10
    Conserved Domains (5) summary
    smart00349
    Location:35 → 96
    KRAB; krueppel associated box
    COG5048
    Location:202 → 562
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:291 → 311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:248 → 272
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    21020657..21060050
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439464.1 → XP_047295420.1  zinc finger protein 430 isoform X1

  2. XM_047439465.1 → XP_047295421.1  zinc finger protein 430 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315962.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    363933..377460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    21159242..21198699
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322229.1 → XP_054178204.1  zinc finger protein 430 isoform X1

  2. XM_054322230.1 → XP_054178205.1  zinc finger protein 430 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H8G1.3 GenPept UniProtKB/Swiss-Prot:Q9H8G1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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