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akr1a1b aldo-keto reductase family 1, member A1b (aldehyde reductase) [ Danio rerio (zebrafish) ]

Gene ID: 799805, updated on 4-Jan-2025

Summary

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Official Symbol
akr1a1bprovided by ZNC
Official Full Name
aldo-keto reductase family 1, member A1b (aldehyde reductase)provided by ZNC
Primary source
ZFIN:ZDB-GENE-050417-118
See related
Ensembl:ENSDARG00000052030 AllianceGenome:ZFIN:ZDB-GENE-050417-118
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
akr1a1; zgc:110225
Summary
Enables aldo-keto reductase (NADPH) activity. Involved in glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in apical plasma membrane. Predicted to be active in cytosol. Is expressed in several structures, including eye; heart; immune system; liver; and muscle. Orthologous to human AKR1A1 (aldo-keto reductase family 1 member A1). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
human mouse all
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Genomic context

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See akr1a1b in Genome Data Viewer
Location:
chromosome: 6
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (33918813..33925432, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (33934123..33940739, complement)

Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 17 Neighboring gene nuclear autoantigenic sperm protein (histone-binding) Neighboring gene pre-mRNA processing factor 38A Neighboring gene origin recognition complex, subunit 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of Tilapia (Oreochromis niloticus) aldehyde reductase (AKR1A1) gene, promoter and expression pattern in benzo-a-pyrene exposed fish. Hassanin A, et al. Toxicol Mech Methods, 2017 Jan. PMID 27800707
  2. Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. Li X, et al. iScience, 2020 Dec 18. PMID 33251496, Free PMC Article
  3. Lipid-related metabolism during zebrafish embryogenesis under unbalanced copper homeostasis. Li C, et al. Fish Physiol Biochem, 2022 Dec. PMID 36161547
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC110225

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables S-nitrosoglutathione reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables aldo-keto reductase (NADPH) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables aldose reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables all-trans-retinol dehydrogenase (NAD+) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on NAD(P)H IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aldehyde catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular detoxification of aldehyde ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
aldo-keto reductase family 1 member A1-B
Names
S-nitroso-CoA reductase
alcohol dehydrogenase [NADP(+)] B
alcohol dehydrogenase [NADP+] B
aldehyde reductase-B
aldo-keto reductase family 1, member A1
scorR
NP_001017640.1
XP_005166342.1
XP_005166343.1
XP_005166344.1
XP_005166346.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001017640.1 → NP_001017640.1  aldo-keto reductase family 1 member A1-B

    See identical proteins and their annotated locations for NP_001017640.1

    Status: PROVISIONAL

    Source sequence(s)
    BC092808
    UniProtKB/Swiss-Prot
    Q568L5
    Related
    ENSDARP00000119785.1, ENSDART00000145019.3
    Conserved Domains (2) summary
    COG0656
    Location:1 → 297
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:9 → 293
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007117.7 Reference GRCz11 Primary Assembly

    Range
    33918813..33925432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005166286.5 → XP_005166343.1  aldo-keto reductase family 1 member A1-B isoform X2

    See identical proteins and their annotated locations for XP_005166343.1

    UniProtKB/TrEMBL
    A0A8M2BDV8, F1R3J0
    Related
    ENSDARP00000122715.1, ENSDART00000141822.3
    Conserved Domains (2) summary
    COG0656
    Location:2 → 299
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 295
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  2. XM_005166285.4 → XP_005166342.1  aldo-keto reductase family 1 member A1-B isoform X1

    UniProtKB/TrEMBL
    A0A8M2BDN5
    Related
    ENSDARP00000113164.1, ENSDART00000137268.3
    Conserved Domains (2) summary
    COG0656
    Location:27 → 324
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:36 → 320
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  3. XM_005166289.5 → XP_005166346.1  aldo-keto reductase family 1 member A1-B isoform X2

    See identical proteins and their annotated locations for XP_005166346.1

    UniProtKB/TrEMBL
    A0A8M2BDV8, F1R3J0
    Conserved Domains (2) summary
    COG0656
    Location:2 → 299
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 295
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  4. XM_005166287.4 → XP_005166344.1  aldo-keto reductase family 1 member A1-B isoform X2

    See identical proteins and their annotated locations for XP_005166344.1

    UniProtKB/TrEMBL
    A0A8M2BDV8, F1R3J0
    Conserved Domains (2) summary
    COG0656
    Location:2 → 299
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 295
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395259.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    224179..232005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q568L5.1 GenPept UniProtKB/Swiss-Prot:Q568L5

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