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ZNF442 zinc finger protein 442 [ Homo sapiens (human) ]

Gene ID: 79973, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF442provided by HGNC
Official Full Name
zinc finger protein 442provided by HGNC
Primary source
HGNC:HGNC:20877
See related
Ensembl:ENSG00000198342 AllianceGenome:HGNC:20877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.4), thyroid (RPKM 0.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF442 in Genome Data Viewer
Location:
19p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (12345944..12373779, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (12474291..12502125, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (12456758..12476497, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 44 Neighboring gene ribosomal protein L28 pseudogene 5 Neighboring gene MPRA-validated peak3363 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14048 Neighboring gene ribosomal protein S2 pseudogene 53 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14049 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:12444503-12445368 Neighboring gene zinc finger protein 563 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14052 Neighboring gene ribosomal protein S29 pseudogene 23 Neighboring gene NANOG hESC enhancer GRCh37_chr19:12501177-12501678 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14053 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14054 Neighboring gene zinc finger protein 799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10150 Neighboring gene zinc finger protein 443

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile. Dendoncker K, et al. Proc Natl Acad Sci U S A, 2019 Jun 25. PMID 31182584, Free PMC Article
  2. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • FLJ14356

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 442

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363774.2 → NP_001350703.1  zinc finger protein 442 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC008758, AK295923, DA151257, DC395131
    Consensus CDS
    CCDS86707.1
    Related
    ENSP00000388634.1, ENST00000438182.5
    Conserved Domains (2) summary
    COG5048
    Location:166 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:449 → 469
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_030824.3 → NP_110451.1  zinc finger protein 442 isoform 1

    See identical proteins and their annotated locations for NP_110451.1

    Status: VALIDATED

    Source sequence(s)
    AC008758, AK024418, DA151257
    Consensus CDS
    CCDS12271.1
    UniProtKB/Swiss-Prot
    B4DJ48, Q9H7R0
    Related
    ENSP00000242804.4, ENST00000242804.9
    Conserved Domains (5) summary
    smart00349
    Location:29 → 69
    KRAB; krueppel associated box
    COG5048
    Location:160 → 563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:29 → 65
    KRAB; KRAB box
    pfam13465
    Location:307 → 332
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    12345944..12373779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027317.2 → XP_016882806.1  zinc finger protein 442 isoform X1

  2. XM_006722908.4 → XP_006722971.1  zinc finger protein 442 isoform X2

    See identical proteins and their annotated locations for XP_006722971.1

    Conserved Domains (5) summary
    smart00349
    Location:22 → 62
    KRAB; krueppel associated box
    COG5048
    Location:153 → 556
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:511 → 531
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:22 → 58
    KRAB; KRAB box
    pfam13465
    Location:300 → 325
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017027316.2 → XP_016882805.2  zinc finger protein 442 isoform X1

RNA

  1. XR_007067014.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    12474291..12502125 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322216.1 → XP_054178191.1  zinc finger protein 442 isoform X1

  2. XM_054322215.1 → XP_054178190.1  zinc finger protein 442 isoform X2

  3. XM_054322214.1 → XP_054178189.1  zinc finger protein 442 isoform X1

RNA

  1. XR_008485203.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H7R0.1 GenPept UniProtKB/Swiss-Prot:Q9H7R0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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