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NOL10 nucleolar protein 10 [ Homo sapiens (human) ]

Gene ID: 79954, updated on 3-Apr-2024

Summary

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Official Symbol
NOL10provided by HGNC
Official Full Name
nucleolar protein 10provided by HGNC
Primary source
HGNC:HGNC:25862
See related
Ensembl:ENSG00000115761 MIM:616197; AllianceGenome:HGNC:25862
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PQBP5
Summary
Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 4.5), adrenal (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p25.1
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10570754..10689975, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10600793..10720003, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10710880..10830101, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10600271-10600772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10600773-10601272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10606558-10607058 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10607059-10607559 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10609230-10609744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10609745-10610259 Neighboring gene ODC1 divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10616917-10617620 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10617621-10618324 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10618316-10618506 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10627262-10627772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10627773-10628281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15305 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15306 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15308 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10637679-10638211 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10662988-10663488 Neighboring gene uncharacterized LOC105373426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10679827-10680338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:10686337-10687208 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:10687298-10688497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10690693-10691562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10715723-10716922 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:10729319-10730518 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:10794082-10795281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15310 Neighboring gene RNA, 7SL, cytoplasmic 832, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10877794-10877974 Neighboring gene ATPase H+ transporting V1 subunit C2 Neighboring gene RNA, U7 small nuclear 138 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions. Jin X, et al. Nat Commun, 2023 Jan 4. PMID 36599853, Free PMC Article
  2. Human AATF/Che-1 forms a nucleolar protein complex with NGDN and NOL10 required for 40S ribosomal subunit synthesis. Bammert L, et al. Nucleic Acids Res, 2016 Nov 16. PMID 27599843, Free PMC Article
  3. Polar amino acid-rich sequences bind to polyglutamine tracts. Imafuku I, et al. Biochem Biophys Res Commun, 1998 Dec 9. PMID 9875212
  4. A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer. Al Olama AA, et al. Nat Genet, 2014 Oct. PMID 25217961, Free PMC Article
  5. PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer. Shen L, et al. Int J Biol Sci, 2022. PMID 36147463, Free PMC Article

See all (71) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.
    Title: PQBP5/NOL10 maintains and anchors the nucleolus under physiological and osmotic stress conditions.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ13938, FLJ14075

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
nucleolar protein 10
Names
H_NH0074G24.1
polyglutamine binding protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261392.2 → NP_001248321.1  nucleolar protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001248321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AC007314, AC092687
    Consensus CDS
    CCDS58697.1
    UniProtKB/TrEMBL
    A0A8Q3SHX7
    Related
    ENSP00000439663.1, ENST00000538384.5
    Conserved Domains (4) summary
    sd00039
    Location:154 → 189
    7WD40; WD40 repeat [structural motif]
    pfam08159
    Location:456 → 482
    NUC153; NUC153 domain
    cl25539
    Location:156 → 313
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    cl26511
    Location:381 → 642
    Neuromodulin_N; Gap junction protein N-terminal region

  2. NM_001261394.2 → NP_001248323.1  nucleolar protein 10 isoform 3

    See identical proteins and their annotated locations for NP_001248323.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting protein (isoform 3) is shorter compared to isoform 1.
    Source sequence(s)
    AC007314, AC092687
    Consensus CDS
    CCDS58698.1
    UniProtKB/TrEMBL
    A0A8Q3SHW5
    Related
    ENSP00000263837.4, ENST00000345985.7
    Conserved Domains (2) summary
    pfam08159
    Location:432 → 458
    NUC153; NUC153 domain
    cl26511
    Location:357 → 618
    Neuromodulin_N; Gap junction protein N-terminal region

  3. NM_024894.4 → NP_079170.2  nucleolar protein 10 isoform 1

    See identical proteins and their annotated locations for NP_079170.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC007314, AC092687
    Consensus CDS
    CCDS1673.2
    UniProtKB/Swiss-Prot
    A8K3R5, B4DLV0, Q53RC9, Q96TA5, Q9BSC4, Q9H7Y7, Q9H855
    UniProtKB/TrEMBL
    A0A8Q3SHX7
    Related
    ENSP00000371101.5, ENST00000381685.10
    Conserved Domains (4) summary
    COG2319
    Location:24 → 312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:55 → 95
    7WD40; WD40 repeat [structural motif]
    pfam08159
    Location:482 → 508
    NUC153; NUC153 domain
    cl26511
    Location:407 → 668
    Neuromodulin_N; Gap junction protein N-terminal region

RNA

  1. NR_048552.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate 5' exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC007314, AC092687

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    10570754..10689975 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445893.1 → XP_047301849.1  nucleolar protein 10 isoform X1

  2. XM_047445899.1 → XP_047301855.1  nucleolar protein 10 isoform X2

  3. XM_047445897.1 → XP_047301853.1  nucleolar protein 10 isoform X2

  4. XM_047445902.1 → XP_047301858.1  nucleolar protein 10 isoform X5

    Related
    ENSP00000511949.1, ENST00000695472.1

  5. XM_011510400.3 → XP_011508702.1  nucleolar protein 10 isoform X3

    UniProtKB/TrEMBL
    A0A8Q3SHZ5
    Related
    ENST00000695479.1
    Conserved Domains (3) summary
    COG2319
    Location:24 → 312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:55 → 95
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:182 → 339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  6. XM_011510402.3 → XP_011508704.1  nucleolar protein 10 isoform X4

    UniProtKB/TrEMBL
    A0A8Q3SHZ5
    Conserved Domains (3) summary
    COG2319
    Location:24 → 312
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:55 → 95
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:182 → 339
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  7. XM_024453153.2 → XP_024308921.1  nucleolar protein 10 isoform X5

    UniProtKB/TrEMBL
    A0A8Q3SHT2
    Conserved Domains (2) summary
    COG2319
    Location:24 → 302
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:55 → 95
    7WD40; WD40 repeat [structural motif]

RNA

  1. XR_007082254.1 RNA Sequence

  2. XR_007082293.1 RNA Sequence

  3. XR_001738958.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    10600793..10720003 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054343998.1 → XP_054199973.1  nucleolar protein 10 isoform X1

  2. XM_054344000.1 → XP_054199975.1  nucleolar protein 10 isoform X2

  3. XM_054343999.1 → XP_054199974.1  nucleolar protein 10 isoform X2

  4. XM_054344003.1 → XP_054199978.1  nucleolar protein 10 isoform X5

  5. XM_054344001.1 → XP_054199976.1  nucleolar protein 10 isoform X3

  6. XM_054344002.1 → XP_054199977.1  nucleolar protein 10 isoform X4

  7. XM_054344004.1 → XP_054199979.1  nucleolar protein 10 isoform X5

RNA

  1. XR_008486525.1 RNA Sequence

  2. XR_008486526.1 RNA Sequence

  3. XR_008486524.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BSC4.1 GenPept UniProtKB/Swiss-Prot:Q9BSC4

Gene LinkOut

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