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PLPPR3 phospholipid phosphatase related 3 [ Homo sapiens (human) ]

Gene ID: 79948, updated on 11-Apr-2024

Summary

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Official Symbol
PLPPR3provided by HGNC
Official Full Name
phospholipid phosphatase related 3provided by HGNC
Primary source
HGNC:HGNC:23497
See related
Ensembl:ENSG00000129951 MIM:610391; AllianceGenome:HGNC:23497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPR3; PRG2; LPPR3; PRG-2
Summary
The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in bone marrow (RPKM 2.7), brain (RPKM 2.5) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
19p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (812488..823797, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (766962..778213, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (812488..821955, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:782349-782922 Neighboring gene long intergenic non-protein coding RNA 1836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:787176-787746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:787747-788315 Neighboring gene CRISPRi-validated cis-regulatory element chr19.128 Neighboring gene CRISPRi-validated cis-regulatory element chr19.129 Neighboring gene hESC enhancers GRCh37_chr19:796571-797206 and GRCh37_chr19:797405-798290 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:798291-799174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:803235-803757 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 4745 Neighboring gene microRNA 3187 Neighboring gene azurocidin 1 Neighboring gene proteinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
  2. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  3. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
  4. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. Huttlin EL, et al. Cell, 2015 Jul 16. PMID 26186194, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phospholipid phosphatase-related protein type 3
Names
PAP-2-like protein 2
inactive phospholipid phosphatase PLPPR3
lipid phosphate phosphatase-related protein type 3
plasticity-related gene 2 protein
NP_001257295.1
NP_079164.1
XP_011526619.1
XP_054178182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270366.2 → NP_001257295.1  phospholipid phosphatase-related protein type 3 isoform 2

    See identical proteins and their annotated locations for NP_001257295.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
    Source sequence(s)
    AC004799, AL136596, AY436785, BC012339
    Consensus CDS
    CCDS58636.1
    UniProtKB/Swiss-Prot
    Q6T4P5, Q86XQ4, Q96EH1, Q9BQF9, Q9HAJ4
    Related
    ENSP00000430297.1, ENST00000520876.8
    Conserved Domains (1) summary
    cd03384
    Location:129 → 278
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

  2. NM_024888.3 → NP_079164.1  phospholipid phosphatase-related protein type 3 isoform 1

    See identical proteins and their annotated locations for NP_079164.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
    Source sequence(s)
    AC004799, AC006273, AL136596, BC012339
    Consensus CDS
    CCDS12043.1
    UniProtKB/Swiss-Prot
    Q6T4P5
    Related
    ENSP00000352962.2, ENST00000359894.6
    Conserved Domains (1) summary
    cd03384
    Location:129 → 306
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    812488..823797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528317.4 → XP_011526619.1  phospholipid phosphatase-related protein type 3 isoform X1

    See identical proteins and their annotated locations for XP_011526619.1

    UniProtKB/Swiss-Prot
    Q6T4P5
    Conserved Domains (1) summary
    cd03384
    Location:129 → 306
    PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    766962..778213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322207.1 → XP_054178182.1  phospholipid phosphatase-related protein type 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6T4P5.1 GenPept UniProtKB/Swiss-Prot:Q6T4P5

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