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ADM2 adrenomedullin 2 [ Homo sapiens (human) ]

Gene ID: 79924, updated on 31-Mar-2024

Summary

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Official Symbol
ADM2provided by HGNC
Official Full Name
adrenomedullin 2provided by HGNC
Primary source
HGNC:HGNC:28898
See related
Ensembl:ENSG00000128165 MIM:608682; AllianceGenome:HGNC:28898
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AM2; dJ579N16.4
Summary
This gene encodes a member of the calcitonin gene-related peptide (CGRP)/calcitonin family of hormones that play a role in the regulation of cardiovascular homeostasis, prolactin release, anti-diuresis, anti-natriuresis, and regulation of food and water intake. The encoded protein is proteolytically processed to generate one or more biologically active peptides. [provided by RefSeq, Jul 2015]
Expression
Biased expression in thyroid (RPKM 8.0), kidney (RPKM 5.1) and 12 other tissues See more
Orthologs
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Genomic context

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See ADM2 in Genome Data Viewer
Location:
22q13.33
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (50481543..50486437)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (50990725..50995619)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (50919972..50924866)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene protein phosphatase 6 regulatory subunit 2 Neighboring gene microRNA 12114 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19319 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50883030-50883876 Neighboring gene SET binding factor 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50910985-50911896 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:50911897-50912806 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13979 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:50913717-50914626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13981 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13982 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19321 Neighboring gene myo-inositol oxygenase Neighboring gene lipase maturation factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin(2) G protein-coupled receptor. Babin KM, et al. J Biol Chem, 2023 Jun. PMID 37146967, Free PMC Article
  2. Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation. Kong L, et al. Breast Cancer Res Treat, 2022 Sep. PMID 35896852
  3. Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade. Xiao F, et al. Sci Rep, 2021 Jan 12. PMID 33436794, Free PMC Article
  4. Intermedin alleviates the inflammatory response and stabilizes the endothelial barrier in LPS-induced ARDS through the PI3K/Akt/eNOS signaling pathway. Fan S, et al. Int Immunopharmacol, 2020 Nov. PMID 32892076
  5. Protective effects of intermedin/adrenomedullin-2 in a cellular model of human pulmonary arterial hypertension. Holmes D, et al. Peptides, 2020 Apr. PMID 32017948

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS.
    Title: Reduced PATL2 Impairs the Proliferation of Ovarian Granulosa Cells by Decreasing ADM2 Expression in Patients with PCOS.
  2. Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
    Title: Intermedin alleviates diabetic vascular calcification by inhibiting GLUT1 through activation of the cAMP/PKA signaling pathway.
  3. Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin2 G protein-coupled receptor.
    Title: Adrenomedullin 2/intermedin is a slow off-rate, long-acting endogenous agonist of the adrenomedullin(2) G protein-coupled receptor.
  4. Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation.
    Title: Intermedin (adrenomedullin 2) promotes breast cancer metastasis via Src/c-Myc-mediated ribosome production and protein translation.
  5. Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/beta-Catenin Signaling Pathway.
    Title: Study on Protection of Human Umbilical Vein Endothelial Cells from Amiodarone-Induced Damage by Intermedin through Activation of Wnt/β-Catenin Signaling Pathway.
  6. CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.
    Title: CRIF1 deficiency suppresses endothelial cell migration via upregulation of RhoGDI2.
  7. Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expressiondagger.
    Title: Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression†.
  8. CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.
    Title: CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells.
  9. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
    Title: Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway.
  10. Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade.
    Title: Intermedin facilitates hepatocellular carcinoma cell survival and invasion via ERK1/2-EGR1/DDIT3 signaling cascade.
Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21135

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hormone activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in feeding behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of heart rate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
protein ADM2
Names
intermedin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253845.2 → NP_001240774.1  protein ADM2 preproprotein

    See identical proteins and their annotated locations for NP_001240774.1

    Status: REVIEWED

    Source sequence(s)
    AB236970, AL096767, BC012864
    Consensus CDS
    CCDS33682.1
    UniProtKB/Swiss-Prot
    Q3LFQ0, Q7Z4H4
    Related
    ENSP00000379086.1, ENST00000395737.2
    Conserved Domains (1) summary
    cl27728
    Location:107 → 148
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

  2. NM_001369882.1 → NP_001356811.1  protein ADM2 preproprotein

    Status: REVIEWED

    Source sequence(s)
    AL096767
    Consensus CDS
    CCDS33682.1
    UniProtKB/Swiss-Prot
    Q3LFQ0, Q7Z4H4
    Related
    ENSP00000379087.2, ENST00000395738.2
    Conserved Domains (1) summary
    cl27728
    Location:107 → 148
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    50481543..50486437
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    50990725..50995619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024866.5: Suppressed sequence

    Description
    NM_024866.5: This RefSeq was removed because currently there is insufficient support for the transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7Z4H4.1 GenPept UniProtKB/Swiss-Prot:Q7Z4H4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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