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gp1bb glycoprotein Ib platelet subunit beta [ Danio rerio (zebrafish) ]

Gene ID: 798998, updated on 2-Nov-2024

Summary

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Official Symbol
gp1bbprovided by ZNC
Official Full Name
glycoprotein Ib platelet subunit betaprovided by ZNC
Primary source
ZFIN:ZDB-GENE-081104-406
See related
Ensembl:ENSDARG00000074441 AllianceGenome:ZFIN:ZDB-GENE-081104-406
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
si:dkey-285c2.8
Summary
Predicted to act upstream of or within blood coagulation. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Bernard-Soulier syndrome. Orthologous to human GP1BB (glycoprotein Ib platelet subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gp1bb in Genome Data Viewer
Location:
chromosome: 8
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (4576132..4586719, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (4519426..4530033, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:ch211-166a6.5 Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 37 Neighboring gene septin 5a Neighboring gene zgc:63587

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish von Willebrand factor. Carrillo M, et al. Blood Cells Mol Dis, 2010 Dec 15. PMID 21035359, Free PMC Article
  2. A transgenic zebrafish model for the in vivo study of the blood and choroid plexus brain barriers using claudin 5. van Leeuwen LM, et al. Biol Open, 2018 Feb 2. PMID 29437557, Free PMC Article
  3. Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Lin Q, et al. Leukemia, 2017 May. PMID 27811851
  4. Sex differences in DNA methylation and expression in zebrafish brain: a test of an extended 'male sex drive' hypothesis. Chatterjee A, et al. Gene, 2016 Sep 30. PMID 27259666
  5. Single-Cell RNA-Sequencing Reveals a Continuous Spectrum of Differentiation in Hematopoietic Cells. Macaulay IC, et al. Cell Rep, 2016 Feb 2. PMID 26804912, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Process Evidence Code Pubs
acts_upstream_of_or_within blood coagulation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
platelet glycoprotein Ib beta chain
Names
glycoprotein Ib (platelet), beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144812.1 → NP_001138284.1  platelet glycoprotein Ib beta chain precursor

    Status: PROVISIONAL

    Source sequence(s)
    CU469504
    UniProtKB/TrEMBL
    A0A8M1NSY9, B8JLP1
    Related
    ENSDARP00000118508.1, ENSDART00000143511.3
    Conserved Domains (4) summary
    smart00013
    Location:21 → 54
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:84 → 129
    LRRCT; Leucine rich repeat C-terminal domain
    sd00031
    Location:53 → 75
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:31 → 51
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    4576132..4586719 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068223039.1 → XP_068079140.1  platelet glycoprotein Ib beta chain isoform X1

  2. XM_068223040.1 → XP_068079141.1  platelet glycoprotein Ib beta chain isoform X2

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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