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GGNBP2 gametogenetin binding protein 2 [ Homo sapiens (human) ]

Gene ID: 79893, updated on 3-Apr-2024

Summary

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Official Symbol
GGNBP2provided by HGNC
Official Full Name
gametogenetin binding protein 2provided by HGNC
Primary source
HGNC:HGNC:19357
See related
Ensembl:ENSG00000278311 MIM:612275; AllianceGenome:HGNC:19357
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIF3; LZK1; DIF-3; LCRG1; ZFP403; ZNF403
Summary
Predicted to be involved in spermatogenesis. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of cell population proliferation; and negative regulation of protein phosphorylation. Predicted to be located in cytoplasmic vesicle. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 42.4), bone marrow (RPKM 29.3) and 25 other tissues See more
Orthologs
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Genomic context

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See GGNBP2 in Genome Data Viewer
Location:
17q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (36544919..36589848)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (37530672..37576192)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (34900768..34946278)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 439 Neighboring gene zinc finger HIT-type containing 3 Neighboring gene myosin XIX Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:34889386-34890061 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class W Neighboring gene ribosomal protein S2 pseudogene 50 Neighboring gene uncharacterized LOC107985031 Neighboring gene dehydrogenase/reductase 11 Neighboring gene mitochondrial rRNA methyltransferase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:34983260-34983760

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells. Xu X, et al. Oncol Rep, 2020 Dec. PMID 33125130, Free PMC Article
  2. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells. Yang Z, et al. Andrologia, 2020 Mar. PMID 31797427
  3. GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation. Liu J, et al. Breast Cancer Res Treat, 2019 Feb. PMID 30450530
  4. ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer. Zhu Z, et al. Gynecol Oncol, 2017 Nov. PMID 28864131
  5. Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators. Guan R, et al. Mol Cell Biochem, 2012 Jun. PMID 22350815

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
    Title: Effects of zinc finger protein 403 on the proliferation, migration and invasion abilities of prostate cancer cells.
  2. Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
    Title: Effects of gametogenetin-binding protein 2 on proliferation, invasion and migration of prostate cancer PC-3 cells.
  3. Our data demonstrate that GGNBP2 suppresses cancer aggressiveness by inhibition of IL-6/STAT3 activation in triple-negative breast cancer
    Title: GGNBP2 suppresses triple-negative breast cancer aggressiveness through inhibition of IL-6/STAT3 signaling activation.
  4. Results identified GGNBP2 as a novel tumor suppressor which is downregulated in human breast tumors and cell lines and suggest that GGNBP2 may function as a corepressor to inhibit ERa's transcriptional activity and consequently inhibit tumorigenic potential of breast cancer cells.
    Title: GGNBP2 acts as a tumor suppressor by inhibiting estrogen receptor α activity in breast cancer cells.
  5. The effects of ZFP403 on cell proliferation and metastasis suggest that it may serve as a tumor suppressor in ovarian cancer.
    Title: ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.
  6. Results show that downregulation of RNASET2 and GGNBP2 in drug-resistant ovarian cancer tissues/cells contributes to the regulation of drug resistance in ovarian cancer.
    Title: Downregulation of tumor suppressor gene ribonuclease T2 and gametogenetin binding protein 2 is associated with drug resistance in ovarian cancer.
  7. There is an essential role for ZNF403 in cell proliferation and G2/M cell-cycle transition.
    Title: Knockdown of ZNF403 inhibits cell proliferation and induces G2/M arrest by modulating cell-cycle mediators.
  8. LCRG1 is a novel gene localized to the tumor suppressor locus D17S800-D17S930 involved in laryngeal carcinoma.
    Title: Molecular cloning and characterization of LCRG1 a novel gene localized to the tumor suppressor locus D17S800-D17S930.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21230, FLJ22561, FLJ42090

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in labyrinthine layer blood vessel development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of peptidyl-serine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of tyrosine phosphorylation of STAT protein IEA
Inferred from Electronic Annotation
more info
  
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
gametogenetin-binding protein 2
Names
C3HC4-type zinc finger protein
laryngeal carcinoma related gene 1
laryngeal carcinoma-related protein 1
zinc finger protein 403

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024835.5 → NP_079111.1  gametogenetin-binding protein 2

    See identical proteins and their annotated locations for NP_079111.1

    Status: VALIDATED

    Source sequence(s)
    AF126964, BC137491, DA494492
    Consensus CDS
    CCDS11314.1
    UniProtKB/Swiss-Prot
    B2RPK7, Q96T90, Q9GZR8, Q9H3C7, Q9H767
    UniProtKB/TrEMBL
    A8K3S2
    Related
    ENSP00000478220.1, ENST00000613102.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    36544919..36589848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257689.4 → XP_005257746.1  gametogenetin-binding protein 2 isoform X1

    See identical proteins and their annotated locations for XP_005257746.1

    UniProtKB/TrEMBL
    A8K3S2

  2. XM_011525266.3 → XP_011523568.1  gametogenetin-binding protein 2 isoform X4

    See identical proteins and their annotated locations for XP_011523568.1

    UniProtKB/TrEMBL
    A8K3S2

  3. XM_047436774.1 → XP_047292730.1  gametogenetin-binding protein 2 isoform X5

  4. XM_011525265.4 → XP_011523567.1  gametogenetin-binding protein 2 isoform X2

    See identical proteins and their annotated locations for XP_011523567.1

    UniProtKB/TrEMBL
    A8K3S2

  5. XM_017025107.2 → XP_016880596.1  gametogenetin-binding protein 2 isoform X3

    UniProtKB/TrEMBL
    A8K3S2

  6. XM_047436775.1 → XP_047292731.1  gametogenetin-binding protein 2 isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187614.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    779823..825343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329335.1 → XP_054185310.1  gametogenetin-binding protein 2 isoform X1

  2. XM_054329338.1 → XP_054185313.1  gametogenetin-binding protein 2 isoform X4

  3. XM_054329339.1 → XP_054185314.1  gametogenetin-binding protein 2 isoform X5

  4. XM_054329336.1 → XP_054185311.1  gametogenetin-binding protein 2 isoform X2

  5. XM_054329337.1 → XP_054185312.1  gametogenetin-binding protein 2 isoform X3

  6. XM_054329340.1 → XP_054185315.1  gametogenetin-binding protein 2 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    37530672..37576192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317271.1 → XP_054173246.1  gametogenetin-binding protein 2 isoform X1

  2. XM_054317274.1 → XP_054173249.1  gametogenetin-binding protein 2 isoform X4

  3. XM_054317275.1 → XP_054173250.1  gametogenetin-binding protein 2 isoform X5

  4. XM_054317272.1 → XP_054173247.1  gametogenetin-binding protein 2 isoform X2

  5. XM_054317273.1 → XP_054173248.1  gametogenetin-binding protein 2 isoform X3

  6. XM_054317276.1 → XP_054173251.1  gametogenetin-binding protein 2 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H3C7.1 GenPept UniProtKB/Swiss-Prot:Q9H3C7

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