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pip5k1ca phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a [ Danio rerio (zebrafish) ]

Gene ID: 798876, updated on 14-Nov-2024

Summary

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Official Symbol
pip5k1caprovided by ZNC
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-050208-358
See related
Ensembl:ENSDARG00000076001 AllianceGenome:ZFIN:ZDB-GENE-050208-358
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
pip5k1c; si:dkey-29i9.1; si:ch211-197g15.13
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphatidylinositol metabolic process and phosphorylation. Predicted to be active in plasma membrane. Is expressed in head and pronephric duct. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See pip5k1ca in Genome Data Viewer
Location:
chromosome: 22
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (17543574..17586072, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (17518383..17561103, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene membrane-associated ring finger (C3HC4) 2 Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene glutathione peroxidase 4a Neighboring gene RNA polymerase II, I and III subunit E, b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. De novo missense variants in phosphatidylinositol kinase PIP5KIγ underlie a neurodevelopmental syndrome associated with altered phosphoinositide signaling. Morleo M, et al. Am J Hum Genet, 2023 Aug 3. PMID 37451268, Free PMC Article
  2. Apical PtdIns(4,5)P(2) is required for ciliogenesis and suppression of polycystic kidney disease. Xu W, et al. FASEB J, 2019 Feb. PMID 30321068
  3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol-4-phosphate 5-kinase type-1 gamma; phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
XP_002666296.1
XP_009294612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    17543574..17586072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002666250.7 → XP_002666296.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2

    UniProtKB/TrEMBL
    A0A8M1RRV5, E7F4U5
    Related
    ENSDARP00000060785.6, ENSDART00000060786.7
    Conserved Domains (1) summary
    smart00330
    Location:108 → 448
    PIPKc; Phosphatidylinositol phosphate kinases

  2. XM_009296337.4 → XP_009294612.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1

    UniProtKB/TrEMBL
    A0A8M3B5L6
    Conserved Domains (1) summary
    smart00330
    Location:108 → 448
    PIPKc; Phosphatidylinositol phosphate kinases
Nucleotide Protein Strain
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